Vitamin D metabolism in canine and feline medicine

Parker, Valerie J.; Rudinsky, Adam J.; Chew, Dennis J.

doi:10.2460/javma.250.11.1259

Cited by 30 publications

(48 citation statements)

References 123 publications

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“…We know that vitamin D status and vitamin D metabolites can be affected by various diseases and conditions in dogs (Parker et al . ). Chronic renal disease, cardiovascular disease, gastrointestinal disease, orthopaedic disease, granulomatous infectious disease, primary hyperparathyroidism and neoplasia have all been previously implicated in lowering serum vitamin D3 concentrations (Gow et al .…”

Section: Discussionmentioning

confidence: 97%

25‐Hydroxy vitamin D3 serum concentration in dogs with acute polyradiculoneuritis compared to matched controls

Laws

Kathrani

Harcourt-Brown

et al. 2017

J of Small Animal Practice

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Section: Discussionmentioning

confidence: 97%

25‐Hydroxy vitamin D3 serum concentration in dogs with acute polyradiculoneuritis compared to matched controls

Laws

Kathrani

Harcourt-Brown

et al. 2017

J of Small Animal Practice

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“…It is worth emphasizing the nutritional peculiarity of felines regarding vitamin D metabolism. This species does not use ergocalciferol as efficiently as it does cholecalciferol (Morris, 2002b), unlike dogs, which can efficiently use both forms (Parker, Rudinsky, & Chew, 2017). This may perhaps be explained by the eating habits of these animals in the wild.…”

Section: Vitamin D Me Tabolis M In Dog S and C Atsmentioning

confidence: 94%

“…This species does not use ergocalciferol as efficiently as it does cholecalciferol (Morris, 2002b), unlike dogs, which can efficiently use both forms (Parker, Rudinsky, & Chew, 2017). It is worth emphasizing the nutritional peculiarity of felines regarding vitamin D metabolism.…”

Section: Vitamin D Me Tabolis M In Dog S and C Atsmentioning

confidence: 98%

Vitamin D metabolism in dogs and cats and its relation to diseases not associated with bone metabolism

Zafalon

Risolia

Pedrinelli

et al. 2019

Animal Physiology Nutrition

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Due to the presence of receptors in the cells of numerous body tissues, vitamin D is associated with several physiological functions that go beyond calcium and phosphorus homoeostasis and control of bone metabolism in the body. In humans, several studies have associated lower vitamin D concentrations with numerous diseases, such as cancer, heart disease, autoimmune diseases and infectious diseases, and also with an increase in the total mortality rate of the population. Recently, this nutrient started to gain importance in veterinary medicine, and several articles have shown a correlation between low vitamin D status and diseases unrelated to bone metabolism. The present review aims to highlight the recent publications that investigated this relationship, bringing the evidence that exists so far in dogs and cats. K E Y W O R D S1,25(OH)2D, 25(OH)D, calcidiol, calcitriol, cholecalciferol, hypovitaminosis D

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“…The associations between vitamin D status and disease in animal species has been extensively reviewed elsewhere [11][12][13][14], as have the comparative aspects of metabolic bone diseases related to vitamin D in animal species [77]. This review section will therefore focus on highlighting differences in vitamin D metabolism between animal species and the potential benefits of assessing vitamin D metabolites beyond 25(OH)D in animal health and disease.…”

Section: Vitamin D Metabolism In Veterinary Speciesmentioning

confidence: 99%

“…Extensive reviews on profiling vitamin D metabolites beyond 25(OH)D in humans have recently been published [9,10]. However, there is still limited knowledge of this extensive pathway in veterinary species [11][12][13][14], and importantly, defined reference ranges for even the routinely measured 25(OH)D are lacking in most veterinary species. Some differences in veterinary vitamin D metabolism are recognized; for example, some carnivorous species including dogs and cats cannot produce vitamin D cutaneously [15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Vitamin D Metabolism and Profiling in Veterinary Species

2020

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The demand for vitamin D analysis in veterinary species is increasing with the growing knowledge of the extra-skeletal role vitamin D plays in health and disease. The circulating 25-hydroxyvitamin-D (25(OH)D) metabolite is used to assess vitamin D status, and the benefits of analysing other metabolites in the complex vitamin D pathway are being discovered in humans. Profiling of the vitamin D pathway by liquid chromatography tandem mass spectrometry (LC-MS/MS) facilitates simultaneous analysis of multiple metabolites in a single sample and over wide dynamic ranges, and this method is now considered the gold-standard for quantifying vitamin D metabolites. However, very few studies report using LC-MS/MS for the analysis of vitamin D metabolites in veterinary species. Given the complexity of the vitamin D pathway and the similarities in the roles of vitamin D in health and disease between humans and companion animals, there is a clear need to establish a comprehensive, reliable method for veterinary analysis that is comparable to that used in human clinical practice. In this review, we highlight the differences in vitamin D metabolism between veterinary species and the benefits of measuring vitamin D metabolites beyond 25(OH)D. Finally, we discuss the analytical challenges in profiling vitamin D in veterinary species with a focus on LC-MS/MS methods.

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Vitamin D metabolism in canine and feline medicine

Cited by 30 publications

References 123 publications

25‐Hydroxy vitamin D3 serum concentration in dogs with acute polyradiculoneuritis compared to matched controls

25‐Hydroxy vitamin D3 serum concentration in dogs with acute polyradiculoneuritis compared to matched controls

Vitamin D metabolism in dogs and cats and its relation to diseases not associated with bone metabolism

Vitamin D Metabolism and Profiling in Veterinary Species

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