Vitamin D metabolites in adolescents and young adults with cystic fibrosis: Effects of sun and season

Reiter, Edward O.; Brugman, Sylvia; Pike, J. Wesley; Pitt, Michael J.; Dokoh, Shigeharu; Haussler, Mark R.; Gerstle, Robert; Taussig, Lynn M.

doi:10.1016/s0022-3476(85)80458-3

Cited by 48 publications

(22 citation statements)

References 24 publications

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“…This is especially true in CF, in which several factors apart from hypogonadism, such as high energy turnover, chronic infections, malnutrition, vitamin D deficiency, hyperparathyroidism and medication, might contribute importantly and to a variable extent to body compositional changes and low bone mass (17, 42 -44). Exocrine pancreas insufficiency was present in all patients and vitamin D deficiency and low BMI -as indicators of malnutrition and possible undertreatment -were also confirmed in our study cohort (51)(52)(53)(54). In addition, patients with serum testosterone within the normal range had still lower BMD than healthy controls, supporting the relevance of testosterone-independent factors for the pathogenesis of low BMD in the context of CF.…”

Section: Discussionsupporting

confidence: 79%

Sex steroids and body composition in men with cystic fibrosis

Leifke¹,

Friemert²,

Heilmann

et al. 2003

European Journal of Endocrinology

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Objective: Delayed sexual maturation and low body weight is common in cystic fibrosis (CF). Concomitant data on sex hormones and concomitant body composition are lacking in men with CF. Design: Cross-sectional study. Subjects and methods: Serum levels of testosterone, 17b-oestradiol (E 2 ), 25-hydroxyvitamin D (25(OH)D), sex hormone-binding globulin (SHBG) and LH were measured by RIA and total and regional lean body mass (LBM), fat body mass (FBM), bone mineral content and bone mineral density (BMD) were assessed by dual-energy X-ray absorptiometry, in men with CF (n ¼ 40; age 24:7^5:4 years) and age-matched healthy controls ðn ¼ 28; age 25:7^3:7Þ: Only men without acute disease exacerbation or systemic glucocorticoid treatment were included. Results: Mean levels of hormonal serum parameters differed significantly between healthy controls ðtestosterone ¼ 20:2^5:5 nmol=l; E 2 ¼ 95:0^20:2 pmol=l; 25ðOHÞD ¼ 62:8^28:3 nmol=lÞ and patients ðtestosterone ¼ 15:9^4:1 nmol=l; E 2 ¼ 60:7^19:4 pmol=l; 25ðOHÞD ¼ 39:5^17:8 nmol=l; P , 0:001Þ while no difference was found for SHBG or LH. Eleven (for E 2 , 19 of 40, for 25(OH)D, 20 of 40) out of 40 patients had serum testosterone levels 2 S.D. below the mean of normal. Men with CF showed a relative shift from FBM to LBM and a different body fat distribution compared with healthy controls ðP , 0:01Þ: Testosterone was not correlated with weight, total or regional LBM or FBM, but significantly with BMD ðr ¼ 0:32; P , 0:05Þ independently from body height and 25(OH)D levels. E 2 was correlated with regional and total FBM ðr ¼ 0:48; P , 0:05Þ: In a multiple regression analysis of the joint effect of testosterone and body components on E 2 , a testosteroneindependent effect was found for FBM. Conclusions: CF patients with stable disease have moderately reduced serum testosterone levels. This might already imply detrimental effects on bone. The change in LBM of patients appears to have no direct association with sex hormone levels while low FBM might cause reduced net conversion of serum testosterone to E 2 with possible effects on FBM distribution.

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Section: Discussionsupporting

confidence: 79%

Sex steroids and body composition in men with cystic fibrosis

Leifke¹,

Friemert²,

Heilmann

et al. 2003

European Journal of Endocrinology

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“…Previous studies have documented both low [34,[48][49][50] and normal [50,51] serum 25OHD concentrations in patients with CF. A prevalence of vitamin D deficiency of 38% seen among the current participants is the exact prevalence noted by Haworth et al [34], and participants in that study were also receiving vitamin D supplementation.…”

Section: Discussionmentioning

confidence: 95%

Relationship between insulin-like growth factor I, dehydroepiandrosterone sulfate and proresorptive cytokines and bone density in cystic fibrosis

et al. 2006

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Introduction-Patients with cystic fibrosis (CF) are known to be at risk for early osteoporosis, and the mechanisms that mediate bone loss are still being delineated. The aim of the present investigation was to investigate if a correlation exists in these patients between skeletal measurements by dual-energy x-ray absorptiometry (DXA) and two anabolic factors, dehydroepiandrosterone (DHEA) and insulin-like growth factor I (IGF-I), and proresorptive factors such as the cytokines interleukin-1β, tumor necrosis factor α, and interleukin-6.

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“…Work by Reiter et al 19 correlated the seasons of the year None of the patients in this study were using oral corticoid therapy. Inhaled corticoid was being used both by patients with normal and abnormal BD, without statistical difference.…”

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confidence: 89%

Prevalência de doença mineral óssea em adolescentes com fibrose cística

Caldeira

Fonseca

Gomes

et al. 2008

J. Pediatr. (Rio J.)

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Objective: To evaluate the prevalence of bone mineral disease among adolescents with cystic fibrosis and to relate the findings with the variables studied. Methods:The study enrolled 37 adolescents who were assessed for: nutritional status according to height/age and body mass/age ratios; bone mineral density of the lumbar spine and entire body by densitometry with dual emission X-ray; daily dietary intake according to a 3-day dietary recall; and pulmonary function by the forced expiratory volume in one second test.Results: Mean age was 13.2 (±2.8) years. Nutritional status was adequate in 70.3 and 75.7% of patients according to the height/age and body mass/age indices, respectively; 54.1% of the patients exhibited reduced lumbar spine bone mineral density and 32.5% for the whole body. There was a positive correlation between bone mineral density and body mass index (p = 0.04). Lung disease and pancreatic insufficiency exhibited a correlation with altered bone mineral density. The dietary recall revealed adequate percentages of calcium, phosphorous and calories, according to the nutritional recommendations laid out in the European Cystic Fibrosis Consensus. The multivariate analysis indicated that these variables were not statistically significant. Conclusions:There is a high prevalence of bone mineral disease among adolescents. Good nutritional status, pancreatic enzyme replacement and control of lung disease may have a protective effect on bone mass.J Pediatr (Rio J). 2008;84(1):18-25: Bone mineral density, cystic fibrosis, adolescents.

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Vitamin D metabolites in adolescents and young adults with cystic fibrosis: Effects of sun and season

Cited by 48 publications

References 24 publications

Sex steroids and body composition in men with cystic fibrosis

Sex steroids and body composition in men with cystic fibrosis

Relationship between insulin-like growth factor I, dehydroepiandrosterone sulfate and proresorptive cytokines and bone density in cystic fibrosis

Prevalência de doença mineral óssea em adolescentes com fibrose cística

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