Vitamin D, Parathormone and Associated Minerals among Students in Zagazig District, Sharkia Governorate, Egypt

Badawy, Amal A. El; Aboserea, Mona Mostafa; Seifi, Omnia S. El; Mortada, Eman M.; Bakry, Huny; Waly, Eman H.; Raafat, Nermin; Etewa, Rasha L.; Badawy, S. A. El

doi:10.1024/0300-9831/a000204

Cited by 8 publications

(10 citation statements)

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“…Also, Haq and colleagues [ 28 ] and Al Anouti and colleagues studies done in Emirates (25° 16’ N and 55° 17′ E) [ 29 ] reported a high prevalence of vitamin D deficiency among healthy Emirati adults. The same thing has been proved in Egypt by El Badawy and colleagues’ study [ 30 ].…”

Section: Discussionsupporting

confidence: 73%

Serum 25(OH) vitamin D level and its relation to diabetic peripheral neuropathy in Egyptian patients with type 2 diabetes mellitus

Abdelsadek

Saghier

Raheem

2018

Egypt J Neurol Psychiatry Neurosurg

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BackgroundSome clinical studies demonstrated a significant association between vitamin D deficiency and diabetic peripheral neuropathy (DPN).ObjectiveThis study aims to evaluate the correlation between serum levels of 25(OH) vitamin D and DPN in Egyptian patients with type 2 diabetes mellitus (T2DM).Patients and methodSixty patients were known to have T2DM, which classified into the following: group I included 40 patients with DPN and group II included 20 diabetic patients, without DPN, compared with 30 apparently healthy subjects of matched age and sex as control group. Laboratory investigations including fasting and 2-h postprandial blood glucose levels, serum calcium, phosphorus, glycosylated hemoglobin (HbA1c), lipid profile, serum 25(OH) vitamin D, and nerve conduction studies were carried out for every participant to detect the existence and severity of DPN.ResultsVitamin D deficiency was found in 73.3% of T2DM groups and in 35% of control subjects with statistical significant differences (p < 0.005), and serum level of 25(OH) vitamin D in patients with DPN (21.09 ± 8.38) was less statistically significant than that in patients without DPN (31.12 ± 14.85) (p = 0.001). Mean serum level of 25(OH) vitamin D in patients with painless DPN (10.047 ± 8.12) was less significant than that in patients with painful DPN (18.14 ± 3.85), (p < 0.05). Regression analysis revealed that vitamin D deficiency is one of the independent risk factors of DPN, (OD, 0.914), (p = 0.007).ConclusionVitamin D deficiency has a significant role in the development and severity of DPN in Egyptian patients with T2DM.

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Section: Discussionsupporting

confidence: 73%

Serum 25(OH) vitamin D level and its relation to diabetic peripheral neuropathy in Egyptian patients with type 2 diabetes mellitus

Abdelsadek

Saghier

Raheem

2018

Egypt J Neurol Psychiatry Neurosurg

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“…Our work shows an inverse association between serum 25OHD and PTH. Other authors have observed this correlation [19][20][21] .…”

Section: Discussionsupporting

confidence: 57%

Hiperparatiroidismo secundario al déficit de vitamina D

López-Ramiro

Rubert

Mahíllo

et al. 2016

Rev Osteoporos Metab Miner

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Introduction: Vitamin D is increasingly recognized as playing a significant role in combatting many diseases. One is the development of secondary hyperthyroidism due vitamin D deficiency. To date, laboratory quantification methods of serum vitamin D were not well standardized. It could not be established with certainty from which levels of vitamin D certains abnormalities take place, like an elevation of PTH. The present study was aimed at determining below what vitamin D levels we will find abnormally high levels of PTH, carrying out the vitamin D determination in the laboratory with a standardized, reliable technique. Methods: This descriptive, retrospective study was conducted with patients over 18 years in which determinations were made simultaneously with PTH, 25 (OH) vitamin D (25OHD) and which also have normal values of calcium, glomerular filtration rate and phosphorus. For determining vitamin D, standardized electrochemiluminescence method was used with gas chromatography-mass spectrometry method. Using the Stava version 11 statistical program, the 25OHD was calculated where PTH value was above 70 pg/ml with greater sensitivity and specificity. Results: In all, 4,083 patients were included, of whom 2,858 were women (70%) and 1,225 (30%) males. The mean age of the study population was 60.60 years (standard deviation, 15.29). 74% of the population had a serum PTH under 70 pg/ml (normal values) and 26% had a serum PTH higher tan 70 ng/ml. By constructing the ROC curve levels of 25OHD, depending on PTH values below or above 70 pg/ml, the area under the curve was 0.5962 (p<0.0001). The cut having jointly account the sensitivity and specificity that determined vitamin D levels to predict PTH values above 70 pg/ml was 24 ng/ml. Of the patients with normal PTH, 71% presented normal vitamin D values, while patients with elevated PTH (Greater than 70 pg/ml), almost half had a vitamin D below 24 ng / ml, which increased as the PTH percentage was elevated. Conclusions: The 25OHD value that presents better specificity and sensitivity to predict abnormally high PTH is 24 ng/ml, which is higher than the level reported in previous work, (about 18 ng/ml) value. The results of this study, carried out with an appropriately calibrated method, showed that 44.9% of patients with vitamin D values of less than 24 ng/ml PTH had abnormally high levels, with a normal value of calcium and phosphorus and normal renal function. This percentage is less in those individuals between 18 and 40 years (24%) and reaches 49% beyond 60 years. These patients could be treated with vitamin D to prevent possible secondary hyperparathyroidism due to vitamin deficiency. It is noteworthy that the method of determining vitamin D used must be properly standardized with respect to gas chromatography-tandem mass spectrometry method.

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“…Overall, 53.6 million adults presented both osteoporosis and low bone mass, accounting for about 54% of the American population 50 years of age and older 3 ) . In the case of Egypt, various research has revealed that osteopenia and osteoporosis affected postmenopausal women in proportions of 53.9% and 28.4%, respectively 4 , 5 ) , while 26% and 21.9% of men were respectively affected by the two diseases 6 ) . Similarly, in Saudi Arabia, about 23% of women with ages between 50 and 70 years old suffered from osteoporosis 7 ) .…”

Section: Introductionmentioning

confidence: 99%

The impact of closed versus open kinetic chain exercises on osteoporotic femur neck and risk of fall in postmenopausal women

et al. 2017

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[Purpose] This study aimed to investigate how closed and open kinetic chain exercises differed in their impact on bone mineral density (BMD) and fall risk in postmenopausal women with osteoporosis. [Subjects and Methods] The research sample consisted of 40 postmenopausal women with osteoporosis with ages between 51 and 58 years old. They were divided at random into two groups of 20 each, respectively receiving closed and open kinetic chain exercises. These exercises were administered three times per week over a period of four sequential months. Prior to and following the treatment, Dual X-ray Absorptiometry (DEXA) was used to measure the BMD of the femur neck in every participant, while the Biodex Stability System (BSS) was used to estimate how likely each participant was to sustain a fall. [Results] The strongest effect on BMD and fall risk was recorded by the closed kinetic chain exercise. [Conclusion] Osteoporotic postmenopausal women should be prescribed closed kinetic chain exercise to diminish the effects of the disease and minimise their risk of fall.

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Vitamin D, Parathormone and Associated Minerals among Students in Zagazig District, Sharkia Governorate, Egypt

Cited by 8 publications

References 0 publications

Serum 25(OH) vitamin D level and its relation to diabetic peripheral neuropathy in Egyptian patients with type 2 diabetes mellitus

Serum 25(OH) vitamin D level and its relation to diabetic peripheral neuropathy in Egyptian patients with type 2 diabetes mellitus

Hiperparatiroidismo secundario al déficit de vitamina D

The impact of closed versus open kinetic chain exercises on osteoporotic femur neck and risk of fall in postmenopausal women

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