Vitamin D receptor and progesterone receptor protein and gene expression in papillary thyroid carcinomas: associations with histological features

Yavropoulou, Maria P; Panagiotou, Grigorios; Topouridou, Konstantina; Karayannopoulou, Georgia; Κoletsa, Triantafyllia; Zarampoukas, Thomas; Goropoulos, Apostolos; Chatzaki, Εkaterini; Yovos, John G.; Pazaitou‐Panayiotou, Kalliopi

doi:10.1007/s40618-017-0700-4

Cited by 16 publications

(16 citation statements)

References 28 publications

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“…[56] Vitamin D receptor (VDR) polymorphisms has been demonstrated to have an impact on Vitamin D metabolism in thyroid tissue, which may modulate the anti-tumor effect of Vitamin D in papillary thyroid cancer (PTC). [57] VDR expression in human thyroid cancer cells has been linked to increased ECM protein-1 (ECM1) and type II trans-membrane serine protease-4 (TPMRSS4) expression, which are tissue markers of increased local invasion and metastasis,[58] highlighting the potential role of Vitamin D analogues in down regulating VDR and thus having a beneficial impact on thyroid cancer. Studies have shown that the efficacy of VDR agonist therapy to decrease viable thyroid cancer cell count depends on the FF FokI VDR genotype polymorphisms.…”

Section: Resultsmentioning

confidence: 99%

Vitamin D, thyroid autoimmunity and cancer: An interplay of different factors

Dutta

Sharma

Aggarwal

et al. 2019

Indian J Endocr Metab

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Background and Aims:In spite of large volume of data linking Vitamin D with cardiovascular morbidity, autoimmunity, cancer, and virtually every organ system, Vitamin D and thyroid is a lesser-known aspect of Vitamin D in clinical practice. This article intends to highlight the current literature on the impact of Vitamin D status and supplementation on thyroid autoimmunity and cancer.Methods:References for this review were identified through searches of PubMed for articles published to from 1950 to August 2019 using the terms “thyroid” [MeSH Terms] AND “Vitamin D” [MeSH Terms] OR “thyroid” [All Fields] AND “Vitamin D” [All Fields].Results:Significant inverse correlation was documented between anti-thyroid peroxidase antibody (TPOAb) and serum 25-hydroxy-Vitamin D (25OHD). TPOAb positivity is more prevalent in Vitamin D deficient individuals. A large volume of medical literature is available from observational studies linking Vitamin D with thyroid autoimmunity. Data from interventional studies documenting beneficial effects of Vitamin D on thyroid autoimmunity is also available, but lesser than that from observational studies. Short-term high dose oral Vitamin D supplementation reduces TPOAb titers. Certain Vitamin D receptor (VDR) gene polymorphism have been linked to increased occurrence of autoimmune thyroid disorders (AITD). Vitamin D deficiency, decreased circulating calcitriol has been linked to increased thyroid cancer. Certain VDR gene polymorphisms have been linked with increased as well as decreased occurrence of thyroid cancer. Data is scant on use of Vitamin D and its analogues for treating thyroid cancer.Conclusion:In spite of large volume of medical literature from observational studies linking Vitamin D with thyroid autoimmunity and cancer, meaningful concrete clinical data on impact of Vitamin D supplementation on hard clinical end points in these disorders is lacking, and should be the primary area of research in the next decade.

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Section: Resultsmentioning

confidence: 99%

Vitamin D, thyroid autoimmunity and cancer: An interplay of different factors

Dutta

Sharma

Aggarwal

et al. 2019

Indian J Endocr Metab

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“…One area of intrigue is the role of vitamin D in metastatic papillary thyroid cancer, particularly bone metastases. Clinckspoor et al [ 38 ] and Yavropoulou et al [ 39 ] identified differential expression of the vitamin D receptor and vitamin D enzymatic regulators in those PTCs prone to metastasis. Specifically, the tissue from lymph node metastasis had decreased expression of VDR when compared to the primary tumor.…”

Section: Vitamin D and Papillary Thyroid Carcinomamentioning

confidence: 99%

“…Overexpression of VDR may affect the kinetics of vitamin D binding, thereby downregulating the effects of the protein complex on VDRE and effectively altering the downstream transcription of various proteins involved in tumorigenesis. Yavropoulou et al [ 39 ] studied 45 thyroid samples from patients with PTC, finding both higher VDR and CYP24A1 expression in samples of malignant tissue. In addition, increased CYP24A1 expression was associated with lymph node metastasis.…”

Section: Other Metabolitesmentioning

confidence: 99%

The Role of Vitamin D as a Prognostic Marker in Papillary Thyroid Cancer

Bains

Mur

Wallace

et al. 2021

Cancers

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The role of vitamin D in modulating several cancer-related pathways has received an increasing amount of attention in the past several years. Previous literature has found an abundance of evidence of vitamin D exerting an anti-proliferative, anti-inflammatory, and pro-differentiation effect in various types of cancers including breast, colon, prostate, and pancreatic cancer. Although the link between vitamin D and thyroid cancer remains controversial, both biochemical evidence and clinical studies have attempted to establish a link between papillary thyroid carcinoma (PTC) and vitamin D status. Furthermore, the use of vitamin D as a prognostic marker has received increased attention, both in regards to clinical outcomes and cancer staging. In this review, we briefly discuss the metabolism and proposed mechanism of action of vitamin D in the context of PTC, and explore links between modulators in the vitamin D pathway and progression of PTC. We provide evidence from both clinical studies as well as molecular studies of metabolic targets, including vitamin D receptor and activating enzymes exerting an effect on PTC tissue, which indicate that vitamin D may play a significant prognostic role in PTC.

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“…Knowing the role of CITED1 in PC and the epidemiological evidence of higher incidence in females, it is not surprising to find expression of oestrogen and progesterone receptors in papillary carcinoma. Expression of oestrogen receptor alpha and progesterone receptor has been reported in 19% and 38.7-57% of PC cases, correspondingly [73,74].…”

Section: Immunohistochemistry Of Thyroid Neoplasmsmentioning

confidence: 99%

“…Cancer cells also possess vitamin-D inactivating 24-hydroxylase but not activating enzyme, namely, 1-alpha-hydroxylase. Overexpression of 24-hydroxylase is associated with extrathyroid invasion and lymph node metastases [74].…”

Section: Immunohistochemistry Of Thyroid Neoplasmsmentioning

confidence: 99%

Thyroid Nodules in Diagnostic Pathology: From Classic Concepts to Innovations

Fridrihsone¹,

Štrumfa²,

Strumfs³

et al. 2018

Histopathology - An Update

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Thyroid nodules are frequent in general population, found in 3.7-7% of people by palpation and 42-67% by ultrasonography (US). The differential diagnosis ranges from papillary (PC), follicular (FC) and medullary (MC) carcinomas to follicular adenoma (FA) and colloid goitre. Cancer risk in thyroid nodules varies: 5% in masses found by palpation, 1.6-15% by US, 3.9-11.3% by computed tomography (CT), 5-6% by magnetic resonance imaging (MRI) and 30-50% by positron emission tomography (PET). The final diagnosis depends on fine needle aspiration (FNA) findings and histopathology. The recent WHO classification (2017) is based on classic morphology, including assessment of invasion and nuclei. New entities are defined to designate tumours with doubtful invasion or controversial nuclear features. By immunohistochemistry, PC expresses HBME-1, TROP-2, CITED1 and CK19. Notably, PC can stain for CD20. MC is recognised by neuroendocrine differentiation. To distinguish FA vs. FC, evaluation of HBME-1, p27 and galectin has been suggested. Regarding miRNAs, miR-146b, miR-222, miR-221 and miR-181b are upregulated, while miR-145, miR-451, miR-613 and miR-137 are downregulated in PC. FC features downregulated miR-199a-5p and upregulated miR-197 and miR-346. In MC, miR-21 and miR-129-5p are downregulated. In addition, increased systemic inflammatory reaction can be poor prognostic factor in thyroid cancer. The aim of this chapter is to review classic and innovative histopathology of thyroid nodules for diagnostic pathology practice and research in multidisciplinary thyroid teams.

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Vitamin D receptor and progesterone receptor protein and gene expression in papillary thyroid carcinomas: associations with histological features

Abstract: We provide evidence for the expression pattern of VDR, PR and CYP24A1 in the progression of PTC. Rapid anti-tumor responses of vitamin D in PTC may be blocked due to inactivation of local vitamin D metabolism.

Cited by 16 publications

References 28 publications

Vitamin D, thyroid autoimmunity and cancer: An interplay of different factors

Vitamin D, thyroid autoimmunity and cancer: An interplay of different factors

The Role of Vitamin D as a Prognostic Marker in Papillary Thyroid Cancer

Thyroid Nodules in Diagnostic Pathology: From Classic Concepts to Innovations

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