Vitamin D Receptor gene polymorphisms and susceptibility to type 2 diabetes: evidence from a meta-regression and meta-analysis based on 47 studies

Aravindhan, Surendar; Almasoody, Mohammed Fadhil Mohammed; Selman, Nihad Abdallah; Andreevna, Alekhina Natalia; Ravali, Sahithya; Mohammadi, Payam; Eslami, Mohammad Masoud; Razi, Bahman; Aslani, Saeed; Imani, Danyal

doi:10.1007/s40200-020-00704-z

Cited by 22 publications

(16 citation statements)

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“…[ 27 ] in a Caucasian population and in two spanish populations [ 28 ] which reported that the frequencies of BsmI and FokI genotypes do not differ between the control group and patients with DM1. However, other studies carried out in other ethnic groups show an association between VDR polymorphisms and DM [ 29 , 30 ].…”

Section: Discussionmentioning

confidence: 92%

Osteocalcin associates with bone mineral density and VDR gene polymorphisms in type 1 and type 2 diabetes

Ramírez Ruiz,

Varo Cenarruzabeitia,

Martínez Villanueva

et al. 2023

Advances in Laboratory Medicine / Avances en Medicina De Laboratorio

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Objectives Bone metabolism is impaired in diabetes mellitus (DM). Our objective is to evaluate the association of bone turnover markers (BTM) and vitamin D receptor (VDR) gene polymorphisms with bone mineral density (BMD) in DM type 1 (T1D) and DM type 2 (T2D). Methods 165 patients (53 T1D and 112 T2D) were enrolled. BMD was measured by dual-energy X-ray absorptiometry (DEXA). Plasma osteocalcin (OC), beta-CrossLaps (β-CTX) and N‐amino terminal propeptide of type I collagen (P1NP) and VDR gene polymorphisms were evaluated. Results Participants were 53 T1D (41 years [31–48]) and 112 T2D (60 years [51–66]). BMD were not statistically different between the groups. OC (p<0.001) and P1NP levels (p<0.001) were higher in patients with T1D. The areas under the curve for the prediction of bone pathology were 0.732 (p=0.038) for OC in T1D and 0.697 (p=0.007) in T2D. A significant association was found between lower lumbar BMD and the A allele of BsmI (p=0.03), the A allele of ApaI (p=0.04) and the allele C of the Taql (p=0.046). Also, a significant correlation was found with higher OC levels and the G allele of BsmI (p=0.044), C allele of ApaI (p=0.011), T allele of Taql (p=0.006) and with C allele of FokI (p=0.004). Conclusions The high negative predictive value of the cut-off point for OC suggests that could be useful in excluding the risk suffering bone loss, allowing offering a personalized clinical approach to prevent this pathology.

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Section: Discussionmentioning

confidence: 92%

Osteocalcin associates with bone mineral density and VDR gene polymorphisms in type 1 and type 2 diabetes

Ramírez Ruiz,

Varo Cenarruzabeitia,

Martínez Villanueva

et al. 2023

Advances in Laboratory Medicine / Avances en Medicina De Laboratorio

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“…en una población caucásica y en dos poblaciones españolas [ 28 ], en los que no se observaron diferencias en las frecuencias genotípicas de BsmI y FokI entre el grupo de control y los pacientes con T1D. Sin embargo, otros estudios realizados en otros grupos étnicos muestran una asociación entre los polimorfismos en VDR y la DM [ 29 , 30 ].…”

Section: Discussionunclassified

La osteocalcina se asocia con la densidad mineral ósea y los polimorfismos del gen VDR en la diabetes tipo 1 y 2

Ruiz,

Cenarruzabeitia,

Villanueva

et al. 2023

Advances in Laboratory Medicine / Avances en Medicina De Laboratorio

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Resumen Objetivos El metabolismo óseo se encuentra alterado en la diabetes mellitus (DM). El objetivo de este estudio es evaluar la relación entre los marcadores de remodelado óseo (MRO), los polimorfismos en el gen receptor de la vitamina D (VDR) y la densidad mineral ósea (DMO) en la DM tipo 1 (T1D) y tipo 2 (T2D). Métodos Se incluyó a 165 pacientes (53 T1D y 112 T2D). La DMO se midió mediante absorciometría de rayos X de energía dual (DEXA). Se realizó un análisis de la osteocalcina (OC) en plasma, beta-CrossLaps (β-CTX), propéptido aminoterminal del procolágeno tipo 1 (P1NP) y los polimorfismos en el gen VDR. Resultados Se incluyó a 53 pacientes con T1D (41 años (31–48)) y 112 con T2D (60 años [51–66]). No se observaron diferencias estadísticamente significativas en relación a la DMO. Los pacientes con T1D presentaron niveles superiores de OC (p<0,001) y P1NP (p<0,001). Las áreas bajo la curva para la predicción de patología ósea para la OC fueron 0,732 (p=0,038) en T1D y 0,697 (p=0,007) en T2D. Se observó una relación estadísticamente significativa entre el alelo A de BsmI (p=0,03), el alelo A de ApaI (p=0,04) y el alelo C de Taql (p=0,046) y una menor DMO. Así mismo, se encontró una correlación significativa entre los niveles elevados de OC y el alelo G de BsmI (p=0,044), el alelo C de ApaI (p=0,011), el alelo T de Taql (p=0,006) y el alelo C de FokI (p=0,004). Conclusiones El elevado valor predictivo negativo del punto de corte de la OC indica que la OC podría ser útil a la hora de descartar el riesgo de pérdida ósea, lo que permitiría diseñar un tratamiento personalizado para prevenir dicha patología.

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“…More specifically, several VDR polymorphisms, such as FokI and BsmI, have been associated both in children and in adults with defective insulin secretion and IGT, thus increasing the risk of overt T2D [86,87]. The results of studies in mice [88] and of a recent meta-analysis [89] confirmed the association between VDR polymorphisms and defective insulin secretion or susceptibility to T2D, thus further supporting the importance of vitamin D in β-cell function on one hand and the role of genetics in T2D development on the other. Regarding the SLC30A8 gene that codes for the ZnT8 protein, a specific polymorphism has been identified in several studies and meta-analyses to be associated with an increased risk for T2D [90][91][92].…”

Section: Genetics and Epigenetics Role In β-Cell Dysfunctionmentioning

confidence: 99%

Beta Cell Dysfunction in Youth- and Adult-Onset Type 2 Diabetes: An Extensive Narrative Review with a Special Focus on the Role of Nutrients

et al. 2023

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Traditionally a disease of adults, type 2 diabetes (T2D) has been increasingly diagnosed in youth, particularly among adolescents and young adults of minority ethnic groups. Especially, during the recent COVID-19 pandemic, obesity and prediabetes have surged not only in minority ethnic groups but also in the general population, further raising T2D risk. Regarding its pathogenesis, a gradually increasing insulin resistance due to central adiposity combined with a progressively defective β-cell function are the main culprits. Especially in youth-onset T2D, a rapid β-cell activity decline has been observed, leading to higher treatment failure rates, and early complications. In addition, it is well established that both the quantity and quality of food ingested by individuals play a key role in T2D pathogenesis. A chronic imbalance between caloric intake and expenditure together with impaired micronutrient intake can lead to obesity and insulin resistance on one hand, and β-cell failure and defective insulin production on the other. This review summarizes our evolving understanding of the pathophysiological mechanisms involved in defective insulin secretion by the pancreatic islets in youth- and adult-onset T2D and, further, of the role various micronutrients play in these pathomechanisms. This knowledge is essential if we are to curtail the serious long-term complications of T2D both in pediatric and adult populations.

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Vitamin D Receptor gene polymorphisms and susceptibility to type 2 diabetes: evidence from a meta-regression and meta-analysis based on 47 studies

Cited by 22 publications

References 79 publications

Osteocalcin associates with bone mineral density and VDR gene polymorphisms in type 1 and type 2 diabetes

Osteocalcin associates with bone mineral density and VDR gene polymorphisms in type 1 and type 2 diabetes

La osteocalcina se asocia con la densidad mineral ósea y los polimorfismos del gen VDR en la diabetes tipo 1 y 2

Beta Cell Dysfunction in Youth- and Adult-Onset Type 2 Diabetes: An Extensive Narrative Review with a Special Focus on the Role of Nutrients

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