Vitamin D receptorTaqI polymorphism and the risk of prostate cancer: a meta-analysis

Abstract

Numerous previous studies reported the association of Vitamin D receptor gene Taq Ipolymorphism with prostate cancer risk, however these results were controversial. In order to provide a relatively comprehensive description of this relationship, we conducted this meta-analysis by searching PubMed, Embase, and China National Knowledge Infrastructure. Finally, 36 studies with 8,423 cases and 8,887 controls were included. Taq I polymorphism was found to marginally increase the prostate cancer risk in recessive genetic model (tt/Tt vs. TT: Odds Ratio (OR) = 0.89, 95% Confidence Interval (CI) = 0.80–1.00, p = 0.05) and allele genetic model (t vs. T allele: OR = 0.91, 95% CI = 0.84–0.99, p = 0.003) in the overall analysis. Subgroup analyses showed that significant increased risk was found in Asians in homozygote model (tt vs. TT: OR = 0.63, 95% CI = 0.41–0.95, p = 0.029) and allele genetic model (t vs. T: OR = 0.78, 95% CI = 0.67–0.90, p = 0.002), and in the subgroup of population-based controls in all the genetic models. These results suggest that Taq Ipolymorphism might be a risk factor of prostate cancer risk, especially in Asians. It could be considered as a promising target to predict the prostate cancer risk for clinical practice.

The Association of a Novel Identified VDR SNP With Prostate Cancer in African American Men

“…Further, it has been suggested that VDR SNPs may be more related to advanced disease (23,26,(49)(50)(51). Earlier investigations including cases with localized (37), and particularly in the Japanese population (24). Although, VDR SNPs have been evaluated as markers of prostate cancer risk; their impact remains uncertain especially in African-Americans.…”

“…Previously, we reported an association of VDR single nucleotide polymorphisms with prostate specific antigen (PSA) level, Gleason score, and prostate cancer risk in African-American men (21). There are various genetic studies that have investigated the relationship between VDR polymorphisms and prostate cancer risk (23,(25)(26)(27)(28)(29)(30)(31)(32)(33), many of which have suggested statistically significant associations (34)(35)(36)(37), weaker associations (38,39), and no associations (40)(41)(42)(43) between common VDR variants and prostate cancer. However, those studies lack a consensus on how significantly, if at all, the VDR gene variants contribute to prostate cancer (44).…”

Análise da presença de mutações germinativas em genes de reparo do DNA em pacientes portadores de câncer de próstata localizado

“…Polimorfismos específicos também estão vinculados a etnia, este fato pode ser evidenciado pelo aumento do risco de CaP na população asiática estar relacionado a polimorfismos diferentes dos apontados como fator de risco para a população afro-americana (CHEN et al, 2018;DAREMIPOURAN et al, 2019;KANG et al, 2018).…”