Vitamin D receptor polymorphisms and the polycystic ovary syndrome: A systematic review

Reis, Guilherme Victor Oliveira Pimenta; Gontijo, Natália Alves; Rodrigues, Kathryna Fontana; Alves, Michelle Teodoro; Ferreira, Cláudia N.; Gomes, Karina Braga

doi:10.1111/jog.13250

Cited by 44 publications

(27 citation statements)

References 54 publications

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“…Thus, the potential role of low vitamin D levels in COVID-19 severity and the development of a related cytokine storm syndrome merits further well-designed research [ 53 , 54 , 57 , 58 ]. Notably, growing data support an inverse association between vitamin D and the severity of multiple PCOS manifestations, including hyperandrogenism, infertility, insulin resistance, and cardio-metabolic disease [ 63 , 64 ]. Furthermore, meta-analysis data indicate that vitamin D supplementation in women with PCOS might significantly decrease total testosterone and C-reactive protein circulating levels, while it can increase the level of total antioxidant capacity [ 65 , 66 ].…”

Section: Overlap Between Common Pcos Features and Identified Risk Facmentioning

confidence: 99%

Polycystic ovary syndrome (PCOS) and COVID-19: an overlooked female patient population at potentially higher risk during the COVID-19 pandemic

Kyrou

Karteris

Robbins

et al. 2020

BMC Med

102

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Background: In women of reproductive age, polycystic ovary syndrome (PCOS) constitutes the most frequent endocrine disorder. Women with PCOS are considered to typically belong to an age and sex group which is at lower risk for severe COVID-19. Main body: Emerging data link the risk of severe COVID-19 with certain factors such as hyper-inflammation, ethnicity predisposition, low vitamin D levels, and hyperandrogenism, all of which have known direct associations with PCOS. Moreover, in this common female patient population, there is markedly high prevalence of multiple cardio-metabolic conditions, such as type 2 diabetes, obesity, and hypertension, which may significantly increase the risk for adverse COVID-19-related outcomes. This strong overlap of risk factors for both worse PCOS cardiometabolic manifestations and severe COVID-19 should be highlighted for the clinical practice, particularly since women with PCOS often receive fragmented care from multiple healthcare services. Comprehensively informing women with PCOS regarding the potential risks from COVID-19 and how this may affect their management is also essential. Conclusion: Despite the immense challenges posed by the COVID-19 outbreak to the healthcare systems in affected countries, attention should be directed to maintain a high standard of care for complex patients such as many women with PCOS and provide relevant practical recommendations for optimal management in the setting of this fast moving pandemic.

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Section: Overlap Between Common Pcos Features and Identified Risk Facmentioning

confidence: 99%

Polycystic ovary syndrome (PCOS) and COVID-19: an overlooked female patient population at potentially higher risk during the COVID-19 pandemic

Kyrou

Karteris

Robbins

et al. 2020

BMC Med

102

View full text Add to dashboard Cite

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“…Polycystic Ovary Syndrome (PCOS) is the most common endocrine disorder in women of reproductive age (Bachanek et al 2015;Jalilian et al 2015;Bachelot 2016;Glintborg and Andersen 2017;Papadakis et al 2017;Reis et al 2017). The patients usually present hyperandrogenism, amenorrhea, and polycystic ovaries (Palomba et al 2015;Aytan et al 2016;Carvalho et al 2017a;Glintborg and Andersen 2017;Reis et al 2017) but not necessarily all of these conditions, since the existence of a great phenotypic variability (Unluturk et al 2016).…”

mentioning

confidence: 99%

Polycystic Ovary Syndrome as a systemic disease with multiple molecular pathways: a narrative review

Carvalho

Reis

Cândido

et al. 2018

Endocrine Regulations

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Polycystic Ovary Syndrome (PCOS) is characterized by hyperandrogenism, amenorrhea, and polycystic ovaries. This endocrinopathy is associated with many metabolic disorders such as dyslipidemia and insulin resistance, with increased risk of type 2 diabetes mellitus, metabolic syndrome, and cardiovascular complications. Inflammation is likely to play an important role in the promoting these metabolic imbalances, while prothrombotic and pro-oxidative mechanisms further contribute to the cardiovascular risk of these patients. The etiology of PCOS is still not fully understood, but there is evidence of genetic and environmental components. This review aims to discuss some molecular pathways associated with PCOS that could contribute to the better understanding about this syndrome. Recent evidence suggests that intrauterine exposure of female mice to an excess of anti-Müllerian hormone may induce PCOS features in their post-natal life. High cytokine levels and cytokine gene polymorphisms also appear to be associated with the pathophysiology of PCOS. Furthermore, high levels of microparticles may contribute to the altered hemostasis and enhanced inflammation in PCOS. All these mechanisms may be relevant to clarify some aspects of PCOS pathogenesis and inspire new strategies to prevent the syndrome as well as treat its symptoms and mitigate the risk of long-term complications.

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“…One possible postulation may be related to the vitamin D receptor polymorphism which differs between women with PCOS and normal women. This has been shown in a systematic review, 39,40 and its role in ovulatory disorders would warrant further studies.…”

Section: Discussionmentioning

confidence: 80%

Independent association of serum vitamin D with anti‐Mullerian hormone levels in women with polycystic ovary syndrome

Wong

Lam

et al. 2018

Clinical Endocrinology

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Vitamin D receptor polymorphisms and the polycystic ovary syndrome: A systematic review

Cited by 44 publications

References 54 publications

Polycystic ovary syndrome (PCOS) and COVID-19: an overlooked female patient population at potentially higher risk during the COVID-19 pandemic

Polycystic ovary syndrome (PCOS) and COVID-19: an overlooked female patient population at potentially higher risk during the COVID-19 pandemic

Polycystic Ovary Syndrome as a systemic disease with multiple molecular pathways: a narrative review

Independent association of serum vitamin D with anti‐Mullerian hormone levels in women with polycystic ovary syndrome

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