Vitamin D receptor variants and breast cancer risk in the Polish population

Vitamin D, Cancer Risk, and Mortality

“…They found a modest significantly increase in breast cancer risk associated with the ff genotype (OR ¼ 1.16, 95%CI: 1.04-1.28). Similar results were found in three further studies (Barroso et al, 2008;Gapska et al, 2009;Sinotte et al, 2008). Only one study (Anderson, Cotterchio, Cole, & Knight, 2011) found a significant inverse association of FokI ff genotype with breast cancer risk (OR ¼ 0.71, 95%CI: 0.57-0.88).…”

Association Between VDR Polymorphisms and Breast Cancer: An Updated and Comparative Meta-analysis of Crude and Adjusted Odd Ratios

“…Currently, there are still a lot of debates on the relationship between VDR polymorphism and the risk of breast cancer development. Case-control studies on Fok1 in breast cancer showed some evidence of increased risk among ff carriers (Sinotte et al, 2008;Gapska et al, 2009;McKay et al, 2009), which was confirmed by some later metaanalysis Tang et al, 2009;. However, these studies also reported some decreased risk among ff carriers (Anderson et al, 2011), or no association with breast cancer (Curran et al, 1999;Guy et al, 2004;John et al, 2007;Abbas et al, 2008;Engel et al, 2012;Rollison et al, 2012;Fuhrman et al, 2013;Mishra et al, 2013;Shahbazi et al, 2013).…”

“…2013; Shahbazi et al, 2013) but not in others (Buyru et al, 2003;Hefler et al, 2004;VandeVord et al, 2006;Trabert et al, 2007;Sinotte et al, 2008;Gapska et al, 2009;McKay et al, 2009;Anderson et al, 2011;Rollison et al, 2012;Mishra et al, 2013); Apa1 was found with positive relationship in some breast cancer studies (Curran et al, 1999;Sillanpaa et al, 2004;Dalessandri et al, 2012), but negative in others (Cui et al, 2001;Hou et al, 2002;Chakraborty et al, 2009;Anderson et al, 2011;Engel et al, 2012;Mishra et al, 2013); the same as Taq1, with associations in some studies (Cui et al, 2001;, but not in others (Curran et al, 1999;Dunning et al, 1999;Lundin et al, 1999;Hou et al, 2002;Newcomb et al, 2002;Buyru et al, 2003;Sillanpaa et al, 2004;John et al, 2007;Abbas et al, 2008;Chakraborty et al, 2009;Gapska et al, 2009;Anderson et al, 2011;Engel et al, 2012;Mishra et al, 2013); Cdx2, positive in some studies (Anderson et al, 2011;Yao et al, 2012; but not in others (Abbas et al, 2008;Zhou et ...…”

Single-Nucleotide Polymorphisms in Vitamin D–Related Genes May Modify Vitamin D–Breast Cancer Associations

“…Another of the statistically-significant VDR SNPs, rs4516035, was not associated with breast cancer in a previous case-control study (61). We did not corroborate any of the previously observed gene-by-environment interaction effects for the putative functional SNPs in VDR (p=0.30, p=0.54, and p=0.38, for rs2228570/ FokI , rs731236/ TaqI , and rs7975128 respectively, where rs7975128 is highly correlated with rs1544410/ BsmI [r 2 =0.97]).…”