Vitamin D's role in cell proliferation and differentiation

Samuel, S.; Sitrin, Michael D.

doi:10.1111/j.1753-4887.2008.00094.x

Cited by 283 publications

(209 citation statements)

References 80 publications

(181 reference statements)

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“…The most commonly reported effect has been observed due to an arrest at G0/G1 to S transition of cell cycle through multiple mechanisms (Samuel & Sitrin, 2008). Several invitro studies has shown that 1α 25(OH) 2 D 3 inhibits the growth of human breast cancer cells.…”

Section: Cyp24a1mentioning

confidence: 99%

Recent Candidate Molecular Markers: Vitamin D Signaling and Apoptosis Specific Regulator of p53 (ASPP) in Breast Cancer

Patel

Patel²,

Patel³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Section: Cyp24a1mentioning

confidence: 99%

Recent Candidate Molecular Markers: Vitamin D Signaling and Apoptosis Specific Regulator of p53 (ASPP) in Breast Cancer

Patel

Patel²,

Patel³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…It is notable that activities such as regulation of synthesis of metalloproteinase and their inhibitors, activation of fibroblasts, and collagen synthesis are also considered as properties of vitamin D [9][10][11]. These evidences bring this hypothesis in mind that vitamin D can have a role in progression of hepatic damage and CLD.…”

Section: Introductionmentioning

confidence: 97%

Disturbances of parathyroid hormone–vitamin D axis in non-cholestatic chronic liver disease: a cross-sectional study

et al. 2010

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Purpose Liver has an important role in metabolism of vitamin D. This study aimed to evaluate the patterns of vitamin D-parathyroid hormone (PTH) disturbance and correlate it in patients with non-cholestatic chronic liver disease (CLD). Methods A total of 40 healthy controls and 90 consecutive patients with evidence of non-cholestatic CLD due to hepatitis C (n = 28), hepatitis B (n = 26), autoimmune hepatitis (n = 19), and cryptogenic causes (n = 17) were enrolled. Cirrhosis was evident in 51 patients. Serum concentrations of 25-hydroxy vitamin D, PTH, calcium, phosphate, and liver enzymes were measured. Child-Pugh classification was determined in cirrhotic patients. Results Vitamin D deficiency (\50 nmol/l) was found in 46 (51.1%) patients and vitamin D insufficiency (50-80 nmol/l) in 15 (16.7%) patients. Secondary hyperparathyroidism (serum PTH [ 6.8 pmol/l) was present in 6 (6.7%) patients. The prevalence of vitamin D deficiency was significantly higher in cirrhotic versus noncirrhotic patients (76.5 vs. 17.9%; P \ 0.001), whereas there was no significant difference in serum calcium, phosphate, and PTH levels. ChildPugh class B and C patients had significantly lower vitamin D level compared with class A patients (P \ 0.001), whereas there was no significant difference in serum calcium, phosphate, and PTH levels. No significant correlation was seen between vitamin D and PTH, calcium or phosphate levels. Lower serum level of vitamin D was associated with coagulopathy, hyperbilirubinemia, hypoalbuminemia, anemia, and thrombocytopenia. Conclusions Vitamin D inadequacy and the severity of liver dysfunction move in parallel in patients with noncholestatic CLD. Vitamin D assessment and replacement should be considered in the management of patients with non-cholestatic CLD.

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“…9 Reseptor vitamin D merupakan anggota reseptor hormon steroid dan mengatur ekspresi gen dalam ligand-dependent manner. 7,10 Reseptor vitamin D berperan melalui jalur genomik dalam pengaturan pertumbuhan sel dan pada jalur nongenomik melalui penghambatan perkembangan dan progresivitas tumor berupa proses induksi diferensiasi seluler. Melalui ekspresi serta aktivitas enzim brushborders serta memperkuat formasi mikrovili dengan merangsang maturasi dari membran apikal mikrovili pada mukosa saluran cerna dan berperan pula dalam penghambatan proliferasi sel.…”

Section: Pendahuluanunclassified

“…Melalui ekspresi serta aktivitas enzim brushborders serta memperkuat formasi mikrovili dengan merangsang maturasi dari membran apikal mikrovili pada mukosa saluran cerna dan berperan pula dalam penghambatan proliferasi sel. 10 Penelitian menggunakan galur sel terbukti bahwa VDR berperan dalam diferensiasi sel dan menghambat proliferasi sel, hal ini menunjukkan bahwa vitamin D berperan dalam progresivitas tumor. 11 Identifikasi VDR pada jaringan tumor dengan cara pemeriksaan imunohistokimia merupakan metode yang baik dan menjadi modalitas untuk menentukan terapi target.…”

Section: Pendahuluanunclassified

“…Imunoekspresi VDR yang meningkat pada adenokarsinoma kolorektal yang merupakan indikator prognosis yang baik karena VDR yang berikatan dengan calcitriol akan meningkatkan jumlah ocludin, zonula occludens (ZO)-1, -2, dan claudin-2, -12, yaitu suatu komponen pada tight junctions yang berlokasi predominan pada membran plasma. 10,20 Selain itu, VDR dan calcitriol dapat meningkatkan relokalisasi vinculin pada struktur intercelular junction. Data tersebut membuktikan bahwa VDR menginduksi ekspresi protein adhesi interseluler yang penting untuk terbentuknya diferensiasi yang baik dari suatu tumor.…”

Section: Metodeunclassified

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Korelasi Ekspresi Reseptor Vitamin D (VDR) dengan Derajat Diferensiasi dan Stadium Adenokarsinoma Kolorektal

Usman¹,

Erida²,

Yulianti³

et al. 2016

mkb

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AbstrakKeganasan terbanyak ketiga di dunia pada organ kolorektal adalah karsinoma yang berasal dari lapisan epitel mukosa. Modalitas yang digunakan untuk terapi karsinoma kolorektal stadium lanjut selain operasi adalah kemoterapi dan saat ini dikembangkan terapi target sebagai alternatif terapi, yaitu metabolit aktif vitamin D, calcitriol. Calcitriol bekerja sinergis dengan agen kemoterapi yang aktivitasnya dimediasi oleh vitamin D reseptor (VDR). Penelitian ini bertujuan mengetahui korelasi imunoekspresi VDR dengan stadium dan derajat diferensiasi Colorectal carcinoma (CRC) is a malignancy from mucosal epithelium of the colon/rectum. The treatment modalities used for advance stage colorectal carcinoma therapy is chemotherapy, in addition to surgery. Targeted therapy is currently being developed as an alternative therapy. One of the agents used in this therapy is calcitriol. Calcitriol is an active metabolite of vitamin D. Calcitriol works synergistically with chemotherapeutic agents and its activity is mediated by the vitamin D receptor (VDR). VDR plays a role in the inhibition of tumor progression via induction of cellular differentiation and proliferation inhibition. In this study, imunoexpression of vitamin D receptor was examined in conjunction with the staging and degree of differentiation (grading) of colorectal adenocarcinoma. The study objects include 35 colorectal adenocarcinoma paraffin blocks created from colectomy which were collected at the Department of Patology Anatomic of Dr. Hasan Sadikin General Hospital Bandung from January 2009-June 2014. The blocks were divided into three groups of staging (I, II, and III) and three groups of grading: well, moderately, and poorly differentiated. Immunostaining was used to evaluate the VDR immunoexspression by histo-score. The data were tested using rank spearman test. There was a weak negative correlation between VDR imunoexpression and staging(p=0.045, R=-0.341), and a moderate positive correlation between VDR imunoexpression and grading (p=0.000, R=0.558). It is concluded that a significant correlation of VDR imunoexpression with staging and grading of colorectal adenocarcinoma is found and this finding can be used as a reference for further studies in the development of targeted therapies. [MKB. 2016;48(2):123-8]

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Vitamin D's role in cell proliferation and differentiation

Cited by 283 publications

References 80 publications

Recent Candidate Molecular Markers: Vitamin D Signaling and Apoptosis Specific Regulator of p53 (ASPP) in Breast Cancer

Recent Candidate Molecular Markers: Vitamin D Signaling and Apoptosis Specific Regulator of p53 (ASPP) in Breast Cancer

Disturbances of parathyroid hormone–vitamin D axis in non-cholestatic chronic liver disease: a cross-sectional study

Korelasi Ekspresi Reseptor Vitamin D (VDR) dengan Derajat Diferensiasi dan Stadium Adenokarsinoma Kolorektal

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