Vitamin D status among healthy postmenopausal women in South America

González, Gilberto

doi:10.4161/derm.24807

Cited by 16 publications

(7 citation statements)

References 22 publications

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“…The prevalence was found to be 22.7% in South Australia ( 15 ), 24% in Brazil ( 16 ), while the prevalence of vitamin D deficiency in adolescents was found to be 45.4 % in the United Arab Emirates ( 17 ). Nevertheless, the prevalence of vitamin D deficiency was 78.1% in females and 72.4% in males in Saudi Arabia, located in the Middle East as is the United Arab Emirates ( 18 ).…”

Section: Discussionmentioning

confidence: 99%

Vitamin D levels of outpatients admitted to a university hospital in the marmara region of Turkey over 3 years

Sezgın¹,

Öztürk²,

Turkal

et al. 2019

Journal of Medical Biochemistry

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SummaryBackgroundVitamin D regulates calcium and phosphorus metabolism, and it is essential for bone formation. Several factors can affect vitamin D levels in plasma. In present study we compare vitamin D levels of outpatients, who admit to Maltepe University Hospital between 2011 and 2013 and had vitamin D measurements regarding gender, age, and season.MethodsHospital records were evaluated to identify the outpatients with vitamin D levels and their gender, age, and vitamin D levels and the seasons of measurements were recorded.ResultsData of 4860 subjects (74% female) were analyzed and 69.2% were between 18–64 years old. Vitamin D levels were as follows: 43.1% ≤ 10 ng/mL, 31.9% between 10 ng/mL and 20 ng/mL, 16.1% between 20 ng/mL and 30 ng/mL, and only 8.9% ≥ 30 ng/mL. The number of females with vitamin D levels < 10 ng/mL was significantly higher than that of males, while the number of males with vitamin D levels between 10 ng/mL and 20 ng/mL was significantly higher than that of females (P = 0.001) for each of the individuals, 6.2% and 11.1% had sufficient levels in winter and summer, respectively. Overall, it was observed that 6.6% of individuals between 18–44 years old, 8.2% of individuals between 45–64 years old and 10.3% of individuals over 65 years old had vitamin D levels > 30 ng/mL.ConclusionsThe prevalence of vitamin D deficiency in outpatients of Maltepe University Hospital in Marmara region was 75% (< 20 ng/mL).

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Section: Discussionmentioning

confidence: 99%

Vitamin D levels of outpatients admitted to a university hospital in the marmara region of Turkey over 3 years

Sezgın¹,

Öztürk²,

Turkal

et al. 2019

Journal of Medical Biochemistry

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“…Vitamin D 3 , whose active form 1,25(OH) 2 D 3 is a cofactor required for calcium absorption in the gastrointestinal tract, is also strongly correlated with bone density [ 59 ]. Vitamin D insufficiency (25(OH)D 3 serum levels <50 nmol/L) is also not uncommon due to diet, lack of sun exposure, or genetic mutations [ 60 ], and many studies have shown that the majority of postmenopausal women in areas around the world have insufficient vitamin D levels [ 61 , 62 , 63 ].…”

Section: Reviewmentioning

confidence: 99%

Osteoporosis: Modern Paradigms for Last Century’s Bones

Kruger¹,

Wolber²

2016

Nutrients

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The skeleton is a metabolically active organ undergoing continuously remodelling. With ageing and menopause the balance shifts to increased resorption, leading to a reduction in bone mineral density and disruption of bone microarchitecture. Bone mass accretion and bone metabolism are influenced by systemic hormones as well as genetic and lifestyle factors. The classic paradigm has described osteoporosis as being a “brittle bone” disease that occurs in post-menopausal, thin, Caucasian women with low calcium intakes and/or vitamin D insufficiency. However, a study of black women in Africa demonstrated that higher proportions of body fat did not protect bone health. Isoflavone interventions in Asian postmenopausal women have produced inconsistent bone health benefits, due in part to population heterogeneity in enteric bacterial metabolism of daidzein. A comparison of women and men in several Asian countries identified significant differences between countries in the rate of bone health decline, and a high incidence rate of osteoporosis in both sexes. These studies have revealed significant differences in genetic phenotypes, debunking long-held beliefs and leading to new paradigms in study design. Current studies are now being specifically designed to assess genotype differences between Caucasian, Asian, African, and other phenotypes, and exploring alternative methodology to measure bone architecture.

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“…However, data obtained from various populations of community-living postmenopausal women with or without osteoporosis highlight a wide disparity of prevalence rates of 25(OH)D concentration ≤ 20 ng/mL depending on the considered geographical areas [ 7 , 8 ]. For instance, in a European study involving more than 8500 postmenopausal women, the prevalence of 25(OH)D deficiency reached 32.1% when considering the cutoff value of 20 ng/mL [ 9 ], while in Indian, Chinese, and US populations of postmenopausal women, the estimated prevalence rates were 53.3%, 72.1%, and 53%, respectively [ 10 – 12 ].…”

Section: Introductionmentioning

confidence: 99%

Hypovitaminosis D and Its Associated Factors in North Algerian Postmenopausal Women: Results of a Cross-Sectional Study

Oussedik-Lehtihet¹,

Haouichat²,

Hammoumraoui³

et al. 2017

Journal of Nutrition and Metabolism

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Purpose As the vitamin D status of Algerian postmenopausal women was poorly described, this cross-sectional study investigated the prevalence of low vitamin D status in a sample population. Secondarily, predictive factors of this hypovitaminosis D were explored. Methods All the 336 selected women ≥ 45 years from Douera were interviewed to get anthropometric and lifestyle data, reproductive and medical history, medications, and calcium/vitamin D intakes. A blood sample was collected to measure 25-hydroxyvitamin D (25(OH)D) concentrations. Results Approximately 86% of subjects had low vitamin D status (<20 ng/mL). Mean 25(OH)D level was 14.4 ± 5.3 ng/mL with a clear seasonal dynamic and a significant negative correlation with PTH levels (r = −0.15, p=0.006). A multiple regression analysis using the 25(OH)D cutoff value of 17 ng/mL instead of the generally admitted level of 20 ng/mL was performed to increase statistical power. Other seasons than summer (OR 4.159 and 95% CI 2.456–7.043), obesity (≥30 kg/m2, OR 1.826, 95% CI 1.081–3.083), and veiling (OR 3.526, 95% CI 1.090–11.400) were significantly associated with 25(OH)D concentrations <17 ng/mL. Conclusions In North Algeria, the abundant sunlight appears insufficient to fully offset hypovitaminosis D risk factors in postmenopausal women, especially obesity and veiling. It suggests the major need to increase vitamin D supplementation in this subpopulation.

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Vitamin D status among healthy postmenopausal women in South America

Cited by 16 publications

References 22 publications

Vitamin D levels of outpatients admitted to a university hospital in the marmara region of Turkey over 3 years

Vitamin D levels of outpatients admitted to a university hospital in the marmara region of Turkey over 3 years

Osteoporosis: Modern Paradigms for Last Century’s Bones

Hypovitaminosis D and Its Associated Factors in North Algerian Postmenopausal Women: Results of a Cross-Sectional Study

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