Vitamin D status and circulating biomarkers of endothelial dysfunction and inflammation in non-diabetic obese individuals: a pilot study

Ilinčić, Branislava; Stokić, Edita; Stosić, Z; Kojic, Nevena Eremic; Katsiki, Niki; Mikhailidis, Dimitri P.; Isenović, Esma R.

doi:10.5114/aoms.2016.61812

Cited by 29 publications

(12 citation statements)

References 44 publications

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“…In the last decades, a role of hypovitaminosis D has emerged [3]. Since the discovery of vitamin D immunomodulatory function, vitamin D has been proposed as a serum biomarker in several clinical conditions, including neurodegenerative disorders, along with inflammatory and cardiovascular markers [4][5][6][7][8][9][10][11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Klotho and vitamin D in multiple sclerosis: an Italian study

Scazzone¹,

Agnello²,

Sasso³

et al. 2020

aoms

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Introduction: Low vitamin D levels have been recognised as an important risk factor for autoimmune diseases, including multiple sclerosis (MS). MS is a multifactorial disease, the pathogenesis of which contributes both to genetic and environmental factors. Polymorphisms in genes codifying molecules involved in vitamin D homeostasis have been associated with hypovitaminosis D. However, the influence of polymorphisms of Klotho, which codify a protein with a pivotal role in vitamin D metabolism, have never been investigated. The aim of this study was to evaluate the association among genetic variants of Klotho, namely rs1207568 and rs9536314, serum 25(OH)D 3 levels, and multiple sclerosis (both risk and disease progression). Material and methods: 107 patients with MS and 133 healthy controls were enrolled in this study. Serum 25(OH)D 3 levels and genotyping of Klotho SNPs were evaluated in all participants by high-performance liquid chromatography and real-time polymerase chain reaction, respectively. Results: Allelic and genotypic frequencies did not differ between patients and controls. Concerning rs1207568, we found a trend toward lower serum 25(OH)D 3 levels in MS patients with A allele (mutant), both in heterozygosis (AG) and in homozygosis (AA), in comparison to MS patients with G allele in homozygosis (GG) (AG + AA 20.5 ±6.3 μg/l; GG 22.5 ±7.5 μg/l, p = 0.07). Conclusions: Our findings did not identify a role of Klotho in the genetic susceptibility to MS.

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Section: Introductionmentioning

confidence: 99%

Klotho and vitamin D in multiple sclerosis: an Italian study

Scazzone¹,

Agnello²,

Sasso³

et al. 2020

aoms

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“…Vitamin D is an important link in inflammatory pathways [31]. It regulates immunological, circulatory and neurological processes [3,[32][33][34][35][36].…”

Section: Vitamin D -Role In Pathophysiologymentioning

confidence: 99%

“…It regulates immunological, circulatory and neurological processes [3,[32][33][34][35][36]. In adults (but also in the perinatal period) vitamin D regulates the immune system and is an anti-inflammatory agent that slows down the expression of pro-inflammatory cytokines and chemokines such as tumor necrosis factor α (TNF-α), interferon γ (INF-γ), and interleukin 6 (IL-6) [31,34,[37][38][39]. Steroid hormones (e.g., estrogens and progesterone) and human chorionic gonadotropin (HCG) are also connected with vitamin D pathways according to several available studies [38,40].…”

Section: Vitamin D -Role In Pathophysiologymentioning

confidence: 99%

The role of vitamin D in perinatology. An up-to-date review

et al. 2021

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The role of vitamin D in perinatology is a subject of major interest in current medicine. There is growing evidence about the role of maternal vitamin D levels in pregnancy outcomes. The aim of this review is to summarize the current literature about the role of vitamin D in perinatology. Evidence from this review suggests associations between low levels of maternal vitamin D and higher risk of certain obstetrical complications. Vitamin D has been found to be related to preeclampsia, gestational diabetes mellitus, low birth weight, and preterm birth. The current literature supports vitamin D supplementation in pregnant women, but more high-quality data are necessary. The problem that remains is how to achieve an optimal 25-hydroxyvitamin D level. To determine the real benefits of vitamin D supplementation in pregnancy, we need high-quality trials in larger groups.

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“…In western countries, venous thromboembolism (VTE) is composed of pulmonary embolism (PE) and deep venous thrombosis (DVT), and it has been identified as a significant public health concern [7,8]. Undergoing THA and TKA could significantly increase the risk of VTE, whose prevalence rate was estimated as 60% without appropriate prophylaxis [9].…”

Section: Introductionmentioning

confidence: 99%

Effect of tranexamic acid on symptomatic venous thromboembolism in patients undergoing primary total knee arthroplasty

Peng¹,

Wang²,

Weng³

et al. 2020

aoms

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Introduction: This study aimed to investigate the effect of tranexamic acid (TXA) with sequential routine anticoagulation on postoperative symptomatic venous thromboembolism (VTE) in patients undergoing primary total knee arthroplasty (TKA). Material and methods: This was a prospective study with randomized trials. From January 2013 to May 2015, 1880 patients undergoing primary TKA were enrolled in this study. Seven hundred and twenty patients who received TXA injection were included in the TXA group while 1160 patients who received placebo injection were included in the control group. Patients in the TXA group were treated with intravenous TXA or topical intravenous TXA, and all received sequential routine anticoagulation 12 h after the operation. We extracted data of patients' sex, age, primary diagnoses, and comorbidities that could potentially affect the prevalence rate of VTE. To discuss the risk factors of symbolic VTE, comparisons were made within the TXA group between patients with symbolic VTE and non-symbolic VTE. Logistic regression analysis was performed to analyze the concurrent effects of various factors on the prevalence rate of postoperative VTE. Results: Thigh perimeter was not closely associated with TXA injection. Within the TXA group, 24 (3.3%) patients had perioperative symptomatic VTE, 16 (2.2%) deep vein thrombosis (DVT) and 8 (1.1%) pulmonary embolism. High body mass index (BMI), low fibrinogen (Fbg) and simultaneous bilateral TKA were significant risk factors in both univariate analysis and multivariate analysis. Conclusions: Increased BMI, low Fbg, and simultaneous bilateral TKA could act as risk factors for postoperative symptomatic VTE treated with TXA.

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Vitamin D status and circulating biomarkers of endothelial dysfunction and inflammation in non-diabetic obese individuals: a pilot study

Cited by 29 publications

References 44 publications

Klotho and vitamin D in multiple sclerosis: an Italian study

Klotho and vitamin D in multiple sclerosis: an Italian study

The role of vitamin D in perinatology. An up-to-date review

Effect of tranexamic acid on symptomatic venous thromboembolism in patients undergoing primary total knee arthroplasty

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