Vitamin D status and efficacy of vitamin D supplementation in acne patients: A systematic review and meta‐analysis

Abstract

Acne is a chronically inflammatory disease of the skin. 1 Acne is the second most prevalent skin condition after dermatitis and affects about 85% of teenagers and young adults. 2,3 Acne lesions develop in the pilosebaceous units that primarily distribute on the check, chin, forehead, and back. 4 The pathogenesis of acne covers four aspects: hyper seborrhea, altered keratinization of the pilosebaceous duct, Propionibacterium acnes (P. acnes), and inflammation.Previous research studies have confirmed that inflammation plays a significant role in acne formation, development, and resolution. 5 Agak, et al found that the expression IL-17 in human peripheral blood mononuclear cells (PBMCs) from healthy individuals can be induced by P. acnes in vitro. Then, they used the supernatants from cultures of P. acnes to incubate with PBMCs, which caused naive CD4+CD45TA+ T cells to differentiate into Th17 cells. The authors once again took biopsies of normally closed comedone-style acne lesions from which IL-17+ cells were detected in perifollicular infiltrations, confirming their results with clinical significance. 6 There were CD4 T cells, macrophages, cytokines, integrins, and other inflammatory components in the perifollicular area of uninvolved skin from acne patients. 7 They all indicated the role of inflammation in acne. Also, in the recent literature, P. acnes induces proinflammatory cytokines in monocytes and the release of cytokines is dependent on Toll-like receptor 2(TLR2). TLR2+ macrophages were found in acne lesions, infiltrating around pilosebaceous follicles and increased

The impact of clinical nutrition on inflammatory skin diseases

“…A meta-analysis showed an interesting inverse correlation between patients' vitamin D levels and clinical severity of their acne. Vitamin D treatment of sebocytes in vitro showed anti-inflammatory properties with reduced expression of interleukin-6 and matrix-metalloproteinase 9 which might explain a possible pathomechanism [65,66]. Yee et al showed that oral zinc supplementation in acne patients led to a reduced appearance of inflammatory eruptions as compared with a cohort without zinc, concluding that zinc may constitute a safe and cost-effective addition to pharmacotherapy [67,68].…”

Oxidative Stress-Related miRNAs in Patients with Severe Acne Vulgaris

“…It is the most common skin condition after dermatitis and has an estimated global prevalence of 9.38%. [ 20 21 ] Acne patients have not only local tissue damage but also increased oxidative stress burden. [ 8 ] Recent studies have shown that oxidative stress has an important role in acne initiation and progression.…”

Hypovitaminosis D among newly diagnosed pulmonary TB patients and their household contacts in Uganda

“…Similarly, according to a meta-analysis, vitamin D supplementation affected sputum conversion and was therefore recommended for consideration during TB therapy 21 . In contrast, another meta-analysis confirmed no relationship between vitamin D supplementation and sputum conversion 22 .…”