Vitamin D Status and Its Association with Parathyroid Hormone Concentration in Brazilians

Martins, Juliana Sálvio; Palhares, Magda de Oliveira; Teixeira, Octávio Cury Mayrink; Ramos, Mariana Gontijo

doi:10.1155/2017/9056470

Cited by 40 publications

(29 citation statements)

References 37 publications

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“…Our results revealed the serum iPTH level was negatively correlated with the serum 25(OH)D 3 level when the serum 25(OH)D 3 level was lower than 20 ng/mL. When the serum 25(OH)D 3 level was above 20 ng/mL, then no linear correlation between 25(OH)D 3 and iPTH levels was noted, which was consistent with the results of the study by Martins et al among Brazilians [46]. Matejek et al reported a significant relationship between iPTH and 25(OH)D 3 from the second month of life in healthy preterm newborns and that decreasing the 25(OH)D 3 level was accompanied by increasing iPTH [47].…”

Section: Discussionsupporting

confidence: 92%

Infants’ Vitamin D Nutritional Status in the First Year of Life in Northern Taiwan

Chen

et al. 2020

Nutrients

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Vitamin D deficiency (VDD) and insufficiency (VDI) are common among exclusively breastfeeding infants. However, epidemiological evidence for the prevalence of VDD in infants during their first year of life in Taiwan has never been found. This trial determined the prevalence of VDD and VDI and the association between dietary vitamin D and vitamin D nutritional status in Northern Taiwan. A cross-sectional study was conducted on infants who returned to well-baby examinations from October 2012 to January 2014 in three hospitals: Shin Kong Wu Ho-Su Memorial Hospital, Taipei Medical University Hospital, and Shuang Ho Hospital. The specific vitamin D cut-off concentrations for VDD, VDI, and VDS are 25(OH)D3 levels ≤20, 21–29, and ≥30 (ng/mL). Overall, 481 infants’ parents completed a questionnaire comprising questions related to vitamin D nutritional status, including weekly time outdoors, breastfeeding status, anthropometric measurement, and assessment of dietary intake, including milk and complementary food. The results revealed that 197 (41%) and 212 (44%) of infants in their first year of life had VDI and VDD, respectively, by the Endocrine Society guidelines. Breastfed infants had a higher prevalence of VDI (86.1%) than did mixed-fed (51.9%) and formula-fed (38.5%) infants (p < 0.001). The prevalence of VDD was 55.4% in infants aged under six months but increased to 61.6% in infants aged over six months. Infants in the VDI and VDD groups had the same anthropometrics as those in the vitamin D sufficiency (VDS) group. Our results revealed that 25(OH)D3 had a negative correlation with the intact parathyroid hormone (iPTH) when the serum 25(OH)D3 level ≤20 ng/mL (r = −0.21, p = 0.001). The VDS group had a higher total vitamin D intake than did the VDI and VDD groups, which was mainly obtained from infant formula. Our data revealed that dietary vitamin D intake and birth season were major indicators in predicting VDD. Lower dietary vitamin D intake and born in winter and spring significantly increased the odds ratio (OR) for VDI by 1.15 (95% CI 1.09–1.20) and 2.02 (95% CI 1.10–3.70), respectively, and that for VDD by 1.23 (95% CI 1.16–1.31) and 2.37 (95% CI 1.35–4.17) without covariates adjustment, respectively. Furthermore, ORs for VDI and VDD significantly differed after adjustment for covariates. In conclusion, the prevalence of VDI and VDD were high in infants during the first year of life. Breastfeeding infants had difficulty in obtaining sufficient vitamin D from diet. In cases where the amount of sun exposure that is safe and sufficient to improve vitamin D status is unclear, breastfed infants aged below one year old are recommended to be supplemented with vitamin D.

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Section: Discussionsupporting

confidence: 92%

Infants’ Vitamin D Nutritional Status in the First Year of Life in Northern Taiwan

Chen

et al. 2020

Nutrients

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“…A human study in Brazilian population has reported a negative correlation between 25‐hydroxyvitamin D3 and PTH levels . In our study, the levels of calcium were similar between groups.…”

Section: Discussionsupporting

confidence: 78%

Maternal vitamin D deficiency increases the thromboxane/prostacyclin ratio through alterations in the one‐carbon cycle in Wistar rats

2019

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This study aims to test the hypothesis that vitamin D deficiency can influence long‐chain polyunsaturated fatty acid metabolism through alterations in the one‐carbon cycle. Wistar rats (n = 8 per group) were given either a control (1,000 IU D3/kg diet) or a vitamin D deficient (VDD) (0 IU D3/kg diet) diet from pre‐pregnancy to delivery. On day 20 of gestation, pregnant female rats were delivered by C‐section to collect placenta and blood. VDD group demonstrated high serum parathyroid hormone, low serum phosphate, low plasma folate, higher plasma homocysteine, and higher plasma malondialdehyde levels (P < 0.05 for all) as compared to control. Lower protein levels of placental cystathionine‐β‐synthase enzyme (P < 0.05) were observed in the VDD group as compared to control. VDD group demonstrated higher placental mRNA levels of the enzymes phospholipase A2 and cyclooxygenase‐2 (P < 0.05 for both) as compared to control. Protein levels of the enzymes phospholipase A2 and cyclooxygenase‐2 were lower (P < 0.05 for both) in the VDD group as compared to the control group. The ratio of thromboxane B2 and 6‐keto prostaglandin F1α in serum was higher (P < 0.05) in the VDD group as compared to control; although the serum levels of 6‐keto prostaglandin F1α and thromboxane B2 were similar in both the groups. Our findings suggest that increased oxidative stress due to maternal vitamin D deficiency results in the imbalance between the vasoconstrictor (thromboxane B2) and vasodilator (6‐keto prostaglandin F1α) eicosanoids, which may lead to endothelial dysfunction and poor pregnancy outcome. © 2019 BioFactors, 45 (4):548–555, 2019

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“…On the other hand, Augoulea et al reported that an increase in PTH caused by denosumab therapy was not associated with serum 25(OH) D levels 25. Serum 1,25(OH) 2 D 3 levels are strictly regulated by elevations in PTH26 that are initiated by transient changes in calcium levels as reported previously,27 and there is a negative correlation between 25(OH)D and PTH levels in Brazilians 28. Also, Wintermeyer et al have reviewed and reported that 25(OH)D is metabolized to 1,25(OH) 2 D 3 (calcitriol), which is the biologically active form of vitamin D in the kidney 29.…”

Section: Discussionsupporting

confidence: 52%

Calcium and vitamin D supplementation with 3-year denosumab treatment is beneficial to enhance bone mineral density in postmenopausal patients with osteoporosis and rheumatoid arthritis

Suzuki

Nakamura

Kato

2018

TCRM

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BackgroundThis 3-year retrospective study compared the outcomes of bisphosphonate-pretreated denosumab therapy with or without vitamin D and calcium supplementation in postmenopausal osteoporosis (OP) patients with rheumatoid arthritis (RA).Materials and methodsFifty-eight patients under long-term denosumab treatment were divided into groups without (denosumab group; 31 cases) or with (combination group; 27 cases) vitamin D and calcium supplementation. The bone markers of BAP, TRACP-5b, and urinary NTX were measured at baseline and every year for 3 years. We also evaluated bone mineral density (BMD) of the lumbar 1–4 vertebrae (L-BMD) and bilateral total hips (H-BMD) at the same time points.ResultsThere were no significant differences in the percent changes of serum albumin-corrected calcium between the groups. The percent change in TRACP-5b was significantly higher in the combination group at 2 years. Serum 25-hydroxyvitamin D status was persistently high during therapy in both groups, with significant percent increases over baseline at 2 and 6 months in both groups and at 24 months in the combination group. The percent increase from baseline of serum zinc was significantly higher at 3 years in the combination group over the denosumab group. L-BMD and H-BMD were significantly increased at every time point for 3 years vs pretreatment levels in both groups and were significantly higher in the combination group at all time points.ConclusionCompared with denosumab monotherapy, the combination group displayed significantly increased serum zinc, L-BMD, and H-BMD at 3 years in OP patients with RA. Thus, calcium and vitamin D supplementation may be beneficial to enhance BMD gains, but not necessarily 25-hydroxyvitamin D status, in patients with OP and RA under denosumab.

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Vitamin D Status and Its Association with Parathyroid Hormone Concentration in Brazilians

Cited by 40 publications

References 37 publications

Infants’ Vitamin D Nutritional Status in the First Year of Life in Northern Taiwan

Infants’ Vitamin D Nutritional Status in the First Year of Life in Northern Taiwan

Maternal vitamin D deficiency increases the thromboxane/prostacyclin ratio through alterations in the one‐carbon cycle in Wistar rats

Calcium and vitamin D supplementation with 3-year denosumab treatment is beneficial to enhance bone mineral density in postmenopausal patients with osteoporosis and rheumatoid arthritis

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