Vitamin D status: effects on quality of life in osteoporosis among Turkish women

Başaran, Sibel; Güzel, Rengin; Benlidayı, İlke Coşkun; Güler-Uysal, Füsun

doi:10.1007/s11136-007-9257-6

Cited by 44 publications

(33 citation statements)

References 33 publications

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“…Changes from baseline in pain frequency score in Japanese women with postmenopausal osteoporosis treated with RLX or COMBI for 24 weeks. These findings are consistent with previous findings for a beneficial role of vitamin D in health, physical activity, and mental health-related QOL in women with postmenopausal osteoporosis 40 . In a study conducted in 259 Turkish women with postmenopausal osteoporosis, vitamin D insufficiency significantly correlated with decreases in specific domains (physical, social, and mental functions, general health, and total scores) of the Questionnaire of the European Foundation for Osteoporosis 40 .…”

Section: Discussionsupporting

confidence: 93%

Quality of life in Japanese women with postmenopausal osteoporosis treated with raloxifene and vitamin D: post hoc analysis of a postmarketing study

Ohta

Hamaya

Taketsuna

et al. 2014

Current Medical Research and Opinion

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Section: Discussionsupporting

confidence: 93%

Quality of life in Japanese women with postmenopausal osteoporosis treated with raloxifene and vitamin D: post hoc analysis of a postmarketing study

Ohta

Hamaya

Taketsuna

et al. 2014

Current Medical Research and Opinion

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“…There are few studies evaluating the eVect of vitamin D on quality of life in osteoporotic patients [8]. However, the eVect of single and megadose vitamin D medication on functional status, pain, and quality of life and correlations between these parameters without bone mineral density measurement have not been investigated yet.…”

Section: Discussionmentioning

confidence: 99%

The effect of oral and parenteral vitamin D supplementation in the elderly: a prospective, double-blinded, randomized, placebo-controlled study

2011

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Hypovitaminosis D in the elderly causes falls and fractures as a result of impaired neuromuscular functions and also may be a reason for nonspecific musculosceletal pain. The aim of this study is to investigate the benefits of a single dose per os or parenterally administrated vitamin D on increasing the quality of life and functional mobility and decreasing the pain in the elderly. The community-dwelling elderly subjects over 65 years age were included in the study. The subjects were given 300.000 IU Vitamin D via per os and parenteral route and assessed after 4 weeks. The serum creatinine, calcium, phosphorous, ALT, ALP, 24-h urine calcium excretion, PTH, and vitamin D levels, as well as VAS (visual analog scale) for pain assessment, functional mobility with TUG (timed up and go test) and quality of life with SF-36 before and after the treatment were evaluated. The serum vitamin D levels were measured by the RIA method. The subjects were divided into four groups each consisting of 30 subjects. The 1st group took i.m. vitamin D, the 2nd group took i.m. placebo, the 3rd group took p.o. vitamin D, and the 4th group took p.o. placebo. The mean age of all the participants was 70.1 ± 4.3 years. There was no difference in the age and gender between the groups (P > 0.05). After treatment, the PTH level of first group was decreased (P = 0.0001) and the vitamin D level increased (P = 0.0001) significantly. In the third group, the PTH level of first group was decreased (P = 0.0001) and the vitamin D level increased (P = 0.004) and the 24-h calcium excretion in urine (P = 0.015) increased significantly. When the pain, the functional mobility, and the quality of life were evaluated, in the first group, the TUG (P = 0.0001) and the VAS (P = 0.0001) decreased significantly, whereas the SF-36 subtitles: physical functioning (P = 0.0001), role physical (0.006), bodily pain (P = 0.0001), general health (P = 0.007), social functioning (P = 0.05), and mental health (P = 0.048) increased significantly. In group two, the VAS (P = 0.001) decreased, the role physical (P = 0.009), and role emotional (P = 0.034) increased significantly; In group three, the TUG (P = 0.0001) and the VAS (P = 0.002) decreased, whereas the physical function (P = 0.0001) and role physical (0.001) increased significantly; In group four, the VAS (P = 0.007) decreased significantly. The megadose vitamin D administration increases quality of life, decreases pain, and improves functional mobility via po or im route in the elderly.

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“…There is a growing body of research suggesting that vitamin D deficiency is widespread among women in the Middle Eastern countries, and although considerable research has been carried out to determine the prevalence of vitamin D deficiency among adolescent females (Moussavi et al, 2005;Olmez et al, 2006;Siddiqui and Kamfar, 2007), women of childbearing age (Fonseca et al, 1984;Dawodu et al, 1998;Ghannam et al, 1999;Gannage-Yared et al, 2000;Mishal, 2001), veiled/nonveiled women (El-Sonbaty and AbdulGhaffar, 1996;Alagol et al, 2000;Meddeb et al, 2005;Islam et al, 2006;Allali et al, 2008), postmenopausal women (Rassouli et al, 2001) and women with osteoporosis (Lips et al, 2006;Basaran et al, 2007), limited research has been carried out to determine vitamin D status among children in Middle Eastern countries.…”

Section: Introductionmentioning

confidence: 99%

Assessment of serum 25(OH)D concentration in women of childbearing age and their preschool children in Northern Jordan during summer

Gharaibeh

Stoecker

2009

Eur J Clin Nutr

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Objective: To assess vitamin D status in women and their children aged 4-5 years in Northern Jordan during summer. Design: A cross-sectional study in which 93 mother-child dyads volunteered through local community centers between June and July 2007. Anthropometric measurements were performed and information on socioeconomic status, health issues, lifestyle factors and nutritional intake were obtained from mothers through a questionnaire. Main measures: Serum 25(OH)D and serum parathyroid hormone (PTH) levels were measured. Results: Mean age (s.d.) was 34.0 (6.0) years for mothers and 60.7 (5.4) months for children. Maternal body mass index (BMI) was 29.6 (5.6) kg/m 2 with 77% of women having a BMI X25 kg/m 2 . Mean concentration of serum 25(OH)D was 25.6 (9.6) nmol/l in mothers; only two women (2.2%) had 25(OH)D concentrations o12.5 nmol/l, but 48.9% of women had o25.0 nmol/l, and 97.8% of women had o50 nmol/l. No woman had values above 75 nmol/l. Children had higher (Po0.0001) serum 25(OH)D concentrations than did their mothers with a mean of 55.8 nmol/l. The children also had lower (Po0.0001) mean serum PTH concentrations than did their mothers (1.47 vs 3.12 pmol/l, respectively). Only three children had serum 25(OH)D concentration o25 nmol/l, but 39% (n ¼ 34) had 25(OH)D o50.0 nmol/l. Older women and those with five or more pregnancies had significantly reduced mean serum 25(OH)D concentrations. Children living in families with lower income had significantly higher mean serum 25(OH)D concentration as did children consuming fortified milk compared with those consuming non-fortified milk. Conclusion: Despite the abundant sunlight during summer, vitamin D status is a concern for mothers and children in Jordan.

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Vitamin D status: effects on quality of life in osteoporosis among Turkish women

Abstract: Vitamin D insufficiency affects physical, social and mental functions of osteoporosis patients and impairs QOL. Vitamin D was found to be one of the factors affecting QOL.

Cited by 44 publications

References 33 publications

Quality of life in Japanese women with postmenopausal osteoporosis treated with raloxifene and vitamin D: post hoc analysis of a postmarketing study

Quality of life in Japanese women with postmenopausal osteoporosis treated with raloxifene and vitamin D: post hoc analysis of a postmarketing study

The effect of oral and parenteral vitamin D supplementation in the elderly: a prospective, double-blinded, randomized, placebo-controlled study

Assessment of serum 25(OH)D concentration in women of childbearing age and their preschool children in Northern Jordan during summer

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