Vitamin D status in children and adolescents with type 1 diabetes in a specialized diabetes care centre in Bangladesh

Abstract

Objectives High prevalence of vitamin D deficiency (VDD) in children and adolescents with type 1 diabetes (T1D) was found in several epidemiological studies. The current study aimed to assess the Vitamin D status in children and adolescents with T1D and to examine the influence of the disease characteristics on vitamin D status in a specialized care centre in a tertiary hospital in Bangladesh. Methods Participants were enrolled in the cross‐sectional study at the time of a regularly scheduled visit to the CDiC Paediatric Diabetes Center in BIRDEM 2(Bangladesh Institute of Research and Rehabilitation of Diabetes Endocrine and Metabolic Disorders), a tertiary care hospital in Bangladesh. The demographic and clinical data were collected through medical records with a structured questionnaire. Results Among sixty study participants, most had inadequate levels of vitamin D: deficiency 31 (51.7%), insufficiency 14 (23.3%) and sufficiency 15 (25.0%). Participants with vitamin D deficiency (VDD) were significantly older compared to the sufficient and insufficient group (p = .029), and were residing in urban areas (p = .036) and from higher socioeconomic status (p = .014). BMI was significantly higher in VDD compared to the sufficient group (p = .040). Although we observed higher median values of daily insulin requirements and HbA1c values in patients with VDD compared to patients with vitamin D insufficiency or vitamin D sufficiency, these differences did not reach statistical significance. Conclusions The present study revealed that the prevalence of vitamin D deficiency and insufficiency among T1 diabetes children was very high. Future studies in large sample are required to assess hypovitaminosis D in youth with T1D and also the possible relating factors of vitamin D deficiency.

Association of Vitamin D deficiency and vitamin D receptor gene polymorphisms with type 1 diabetes risk: A South Indian familial study

“…Although the significance of vitamin D status in T1D patient is widely known, the influence of Vitamin D deficiency on T1D incidence remains ambiguous (Rak et al 2019). The present study findings of VDD suggest that the VDD is associated with T1D development which is in agreement with the earlier reports from Swedish, Quatrain, North Indian, Iranian, American, Egyptian, Australian, Italian, Saudi Arabian and Bangladesh populations (Littorin et al 2006; Bener et al 2009; Borkar et al 2010, Ghandchi et al 2012; Gorham et al 2012; Azab et al 2013; Greer et al 2013; Franchi et al 2014 and Al-Daghri et al 2014, Zabeen et al 2021). Further, a meta-analysis study also noticed that VDD is significantly higher in the T1D group (De Oliveira et al 2018).…”

Proportion of vitamin D deficiency in children/adolescents with type 1 diabetes: A systematic review and meta-analysis

“…A summary of the selection process for the studies is presented in Fig. 1 Descriptions of included studies Out of the 45 studies, 19 had cross-sectional designs [22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40], 23 were case-control studies , 2 had baseline cross-sectional data from a longitudinal study [64,65] and one was based on the baseline data of a cohort study [66]. The reported data also included 6,995 participants, mostly aged ≤ 18 years old, of which 2,436 were children/adolescents with T1D as well as vitamin D de ciency (sample size n=13~1,426).…”

Seasonal fluctuations in vitamin D levels in children with various diseases

“…Заболевания с непрерывно-прогрессирующим аутоиммунным характером воспаления, такие как СД 1 типа, ВЗК и ИЮА характеризуются глубокими нарушениями метаболизма 25(ОН)D, что согласуется с данными литературы [4,5,8,9,13,23].…”

“…Традиционно наше представление об обеспеченности витамином D детей было по сравнению со взрослыми было более оптимистичным в связи с большей приверженностью детей к приему профилактических доз холекальциферола [1,2]. Однако недавние исследования с включением различных по величине когорт пациентов свидетельствуют о низкой обеспеченности 25(ОН)D как среди практически здоровых детей вне зависимости от региона их проживания, так и среди детей с различными отклонениями в состоянии здоровья [3][4][5][6][7][8][9][10][11][12][13]. Основная проблема исследований по обеспеченности витамином D заключается в отсутствии комплексного подхода, то есть динамической оценки 25(ОН)D в течение всего периода детства и в различные сезоны года.…”