Vitamin D status in endometriosis: a systematic review and meta-analysis

Qiu, Yichao; Yuan, Shuang; Wang, Hongjing

doi:10.1007/s00404-020-05576-5

Cited by 25 publications

(17 citation statements)

References 30 publications

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“…Low levels of serum Vitamin D have been assumed as a risk factor for endometriosis and for increased MBD. However, this relation has been highly demonstrated for the former [ 29 ], but not in the latter condition [ 30 ]. Also, use of dairy products might lower the risk of endometriosis [ 31 ], while the few studies about the association of these products with MBD have showed controversial results from no relation to a negative association [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the association of endometriosis and mammographic breast density, a cross-sectional study

et al. 2022

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Background Endometriosis is a common benign but painful gynecologic condition. Studies suggest that the risk of some types of malignancies such as breast cancer is higher in women with endometriosis. Mammographic breast density (MBD) is known as an important predictor for breast cancer. The present study aimed to investigate the potential relationship between endometriosis and MBD. Methods This cross-sectional study was conducted on 370 women over 40 years of age. Laparoscopic surgery was carried out for the diagnosis of endometriosis. MBD was classified into four categories according to the ACR BI-RADS classification. Statistical analysis was performed using SPSS software to evaluate the potential association between variables. Results The mean age of all participants was 47.2 ± 6.4 years, and most participants (76.8%) were premenopausal. Multivariate analysis of the potential predictors of MBD, including age, body mass index, oral contraceptive consumption, progesterone consumption, family history of breast cancer and endometriosis showed that age (P value = 0.002), history of progesterone consumption (P value = 0.004) and endometriosis (P value = 0.006) were independent factors for MBD. Conclusion This study indicated that endometriosis had an inverse association with MBD. Age and history of progesterone use were also independent influential factors for MBD. This finding shows that the positive association between breast cancer and endometriosis is not mediated through MBD.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the association of endometriosis and mammographic breast density, a cross-sectional study

et al. 2022

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“…Every 10th woman of reproductive age complains of this disease manifestations. Prolonged chronic pelvic pain, infertility, loss of work ability, deterioration of all parameters of quality of life create diffi culties for social adaptation and realization of the female potential in the family and society [1,3,10].…”

Section: ключові слова: ендометріоз яєчника запальні захворювання орг...mentioning

confidence: 99%

“…Other studies have shown controversial results regarding the increased risk of endometriosis if its levels are low [8,9]. The problem is getting worse due to the fact that vitamin D defi ciency in the modern world has become pandemic [1,3,10], and among the population of Ukraine vitamin D defi ciency is found in 81.8% [1,3,7,9]. Controversial and contradictory scientifi c positions in this area reasonably arouse interest in studies on the role of this transmitter in the pathogenesis of endometrial disease, as this clinical condition is associated with the function of the endocrine system, immune system and severe infl ammatory response [4,6].…”

Section: ключові слова: ендометріоз яєчника запальні захворювання орг...mentioning

confidence: 99%

Vitamin D Effect on the Severity of Chronic Pelvic Pain in Patients with Ovarian Endometriosis Combined with Pelvic Inflammatory Diseases

Bihun

2022

Arch. clin. med.

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Numerous publications in recent years indicate the impact of vitamin D deficiency on the course and severity of a number of gynecological diseases, including endometrial disease. As this transmitter is associated with immune disorders, its involvement in local immunosuppression in the progression of the systemic inflammatory response in the case of endometrial disease is not excluded. Considering the pathogenetic links between vitamin D metabolism and the severity of pelvic pain, it became appropriate to study the relationship between this parameter and the intensity of pelvic pain in patients with ovarian endometriomas associated with chronic pelvic inflammatory diseases, which was the objective of this research. Materials and methods of research. The study included 90 patients with ovarian endometriosis aged 20 to 41 years. The main group consisted of 44 patients with endometrioma combined with pelvic inflammatory diseases; the comparison group consisted of 46 patients with isolated ovarian endometrioma. The control group included 30 relatively healthy women without gynecological and somatic pathology. At the initial stage, the level of 25-hydroxyvitamin-D3 (25 (OH) D) was determined in patients of the three groups by mass spectrometry using standard methods. Analysis and discussion of research results. Patients with ovarian endometrial cysts on the background of pelvic inflammatory disease were statistically significantly older compared with the group of isolated endometriomas; more than half of the observations were patients aged 36-40 years (p<0.05). Laparoscopic diagnostic and therapeutic techniques allowed to present objective signs of combination of ovarian endometrioma with manifestations of external genital endometriosis: severe manifestations of external genital endometriosis were diagnosed in 31.8% vs. 15.21% in the comparison group. Depending on the severity of the pain syndrome according to VAS, patients of the main group were stratified as follows: 22.7% noted pelvic pain of low intensity, 40.9% – moderate pain, 25.0% – severe pain; in the comparison group there were no manifestations of severe pelvic pain. The combination of pelvic inflammatory disease with ovarian endometriosis was accompanied by an increase in the share of vitamin D deficiency – in 38.64% and the share of severe pain – in 25.0%. Conclusion. A significantly moderate inverse correlation was found between the verification of the manifestations of external genital endometriosis and the level of vitamin D in the blood serum. The obtained data dictated the need to assess the therapeutic potential of vitamin D in combination with nonsteroidal anti-inflammatory drugs to enhance the analgesic effect and reduce the drug load.

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“…Так, доказана экспрессия рецепторов к витамину D (VDR) в яичниках, матке, плаценте, гипофизе и гипоталамусе [9]. В статье G. Muscogiuri 2020), отмечается, что гиповитаминоз D следует рассматривать в качестве потенциального фактора риска развития эндометриоза [10]. Механизм влияния витамина D на развитие и усугубление эндометриоза объясняется в исследовании M. Miyashita et al (2016), где описано, что витамин D статистически достоверно снижает экспрессию интерлейкина-1b и фактора некроза опухолей-a, подавляя развитие воспалительного ответа [11].…”

Section: ______________________ Abstract ____________________________...unclassified

Влияние Витамина D На Эффективность Программ Экстракорпорального Оплодотворения

Жуковская¹

2021

Репродуктивное Здоровье. Восточная Европа

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В статье представлены результаты ретроспективного когортного исследования, проведенного на базе МЧУП «Центр репродуктивной медицины» (Минск, Беларусь), включившего всебя 343 женщины с первичным бесплодием, которые обратились для проведения экстракорпорального оплодотворения. Сформированы 2 исследуемые группы: группа 1 - 178 женщин, которым проводили экстракорпоральное оплодотворение после достижения целевой концентрации витамина D (>30 нг/мл) в сыворотке крови; группа 2 - 165 женщин, которым проводили экстракорпоральное оплодотворение на фоне недостаточной концентрации (20-30 нг/мл) витамина D в сыворотке крови. Установлено, что недостаточная концентрация витамина D не оказывает достоверного влияния на уровень фолликулостимулирующего (6,1 [3,8; 8,4] против 5,98 [3,9; 8,9] мМЕ/мл, U=13791,0; р=0,329), лютеинизирующего (5,5 [3,7; 7,2] против 5,4 [3,7; 7,4] мМЕ/мл, U=14547,0; р=0,881) и антимюллерова (7,9 [6,3; 8,4] против 7,5 [5,4; 8,5] нг/мл, U=13699,0; р=0,286) гормонов; не оказывает значимого влияния на длительность контролируемой овариальной стимуляции и суммарную дозу гонадотропинов, затраченных на ее проведение, а также на такие эмбриологические критерии эффективности КОС, как количество фолликулов на момент аспирации, число полученных зрелых ооцитов и зигот; ассоциирована с получением меньшего количества бластоцист в сравнении с контрольной группой (U=12772,5; р=0,042); не оказывает достоверного влияния на частоту наступления клинической беременности (49,4% против 47,8%; χ2=0,08; p=0,77); ассоциирована с возрастанием частоты репродуктивных потерь в 1-м триместре: 9,1% против 16,4% (χ2=4,2; p=0,04). Таким образом, целесообразно рекомендовать определение концентрации витамина D в сыворотке крови у женщин в рамках подготовки к программам экстракорпорального оплодотворения и проводить коррекцию при необходимости. This article presents the results of the research performed in “Center of Reproductive Medicine” (Minsk, Belarus), which included 343 women with primary infertility that underwent in-vitro fertilization programs. Two groups were formed: Group 1 (n=178) - women that underwent IVF after obtaining sufficient serum vitamin D concentration (>30 ng/ml); Group 2 (n=165) - women that underwent IVF with insufficient serum vitamin D concentration (20-30 ng/ml). We established that insufficient serum vitamin D concentration had no statistically significant impact on FSH level (6,1 [3,8; 8,4] vs 5,98 [3,9; 8,9] mIU/ml, U=13791,0; р=0,329), LH level (5,5 [3,7; 7,2] vs 5,4 [3,7; 7,4] mIU/ ml, U=14547,0; р=0,881), and AMH level (7,9 [6,3; 8,4] vs 7,5 [5,4; 8,5] ng/ml, U=13699,0; р=0,286). We also found no significant impact of vitamin D insufficiency on controlled ovarian stimulation duration, total gonadotropin dose, and such embryologic criteria of COS efficiency as number of aspirated follicles, number of mature oocytes and zygotes. However, vitamin D insufficiency was associated with significantly lower number of obtained blastocysts in comparison with control group (U=12772,5; р=0,042). Analyzing the influence of vitamin D insufficiency on IVF efficacy we established that it has no impact on clinical pregnancy rate (49,4% vs 47,8%; χ2=0,08; p=0,77), but is associated with statistically significant increase in the rate of reproductive loss in 1st trimester: 9,1% versus 16,4% (χ2=4,2; p=0,04). Therefore, we conclude that it might be beneficial to recommend routine screening for vitamin D insufficiency and obtain optimal levels of serum vitamin D before starting infertility treatment programs such as IVF.

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Vitamin D status in endometriosis: a systematic review and meta-analysis

Cited by 25 publications

References 30 publications

Evaluation of the association of endometriosis and mammographic breast density, a cross-sectional study

Evaluation of the association of endometriosis and mammographic breast density, a cross-sectional study

Vitamin D Effect on the Severity of Chronic Pelvic Pain in Patients with Ovarian Endometriosis Combined with Pelvic Inflammatory Diseases

Влияние Витамина D На Эффективность Программ Экстракорпорального Оплодотворения

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