Vitamin D status in Hashimoto’s thyroiditis and its association with vitamin D receptor genetic variants

Hanna, Hany William Z.; Rizzo, Cristiano; Halim, Radwa Marawan Abdel; Haddad, Hemmat Elewa El; Salam, Randa; Abou-Youssef, Hazem S.

doi:10.1016/j.jsbmb.2021.105922

Cited by 11 publications

(15 citation statements)

References 24 publications

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“…Stress and increased iodine intake are two environmental triggers of HT. On the other hand, the autoimmune response that characterizes HT disease may be caused by genetic differences in some in ammatory genes and thyroid-speci c genes such as the Tg gene (Xiaoheng et al, 2017;Hanna et al, 2021). The activity of vitamin D is mediated through vitamin D receptor (VDR).…”

Section: Introductionmentioning

confidence: 99%

“…Vitamin D is a crucial vitamin for the body. A de ciency in vitamin D has been linked to a variety of health problems, including cardiovascular disease, type 1 diabetes, some malignancies like breast cancer, autoimmune diseases, depression, and allergies (Hanna et al, 2021). Vitamin D is assumed to affect the body via both non-genomic and genomic mechanisms (Reis et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

“…Numerous allelic variants or polymorphisms have been linked to VDR, with FokI (rs2228570), BsmI (rs1544410), TaqI (rs731236), and ApaI (rs7975232) being the most frequently investigated (Fig. 1) (Hanna et al, 2021). The FokI polymorphism is found at the chromosome initiation codon, while the BsmI, ApaI and TaqI polymorphisms are found in the 3′ untranslated regions (Chauhan and Medithi, 2021).…”

Section: Introductionmentioning

confidence: 99%

“…The single-nucleotide polymorphisms (SNPs) in the VDR gene are critical to human physiology because plasma levels and activity of vitamin D are dramatically in uenced by these polymorphisms (Dastani and Richards, 2013;Gnanaprakash et al, 2019). VDR gene FokI variant is a functional single nucleotide polymorphism (SNP) that extends lengths of the receptor protein, while BsmI, ApaI and TaqI are believed to alter mRNA stability (Al-Kashwan et al, 2021; Hanna et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

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Genetic polymorphisms of vitamin D receptor gene and the risk of Hashimoto's thyroiditis: an Iraqi case-control study

Majid

Abulrazzaq

Al-Koofee

et al. 2023

Preprint

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Background Recently, the vitamin D receptor gene polymorphisms has been linked to various autoimmune diseases. The key aim of this study is to explore the association between VDR gene polymorphisms (rs2228570, rs1544410, rs731236, rs7975232) and the risk of Hashimoto's thyroiditis (HT) among the Iraqi population. Methods Peripheral blood samples were used to isolate genomic DNAs from 180 HT patients and 200 healthy controls. Four VDR gene loci were amplified, and the obtained amplicons were then digested using the restriction enzymes FokI, BsmI, TaqI and ApaI. The digested fragments were then electrophoresed on agarose gel (2.5%). HT polymorphisms and estimated haplotypes were computed by odds ratios (ORs). Results After stratification by age, gender and body mass index (BMI), univariate logistic regression statistical analysis revealed a significantly higher incidence of FokI (rs2228570) polymorphisms in HT patients compared to healthy controls. In contrast, the incidence of the BsmI (rs1544410) and TaqI (rs731236) polymorphisms were significantly higher in healthy controls than in the HT patient group. Linkage disequilibrium (LD) analysis of pairs of SNPs revealed that the polymorphisms in the VDR gene (rs731236 A/G and rs7975232 G/C) were in strong LD in an HT model (D’= 0.86). Furthermore, AAGC and AAGT haplotype models (OR = 1.50, 95% CI: 1.09 − 2.07; OR = 1.61, 95% CI: 1.06 − 2.45, P = 0.02) were associated with an increased risk of HT, while the AACC haplotype model (OR = 0.37, 95% CI: 0.15–0.90, P = 0.02) exhibited a significantly decreased the risk of developing HT. Conclusion Our research supports the association between HT and the FokI polymorphism among the Iraqi population. In addition, the haplotype analysis reveals that the combination of mutant alleles from several VDR gene polymorphisms makes these individuals more susceptible to HT.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Genetic polymorphisms of vitamin D receptor gene and the risk of Hashimoto's thyroiditis: an Iraqi case-control study

Majid

Abulrazzaq

Al-Koofee

et al. 2023

Preprint

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“…Amiodarone (AMD) is a common iodine-containing drugs, that is widely used in the treatment of various arrhythmias as class III antiarrhythmias (Lee et al 2021). Studies have shown that thyroid function injury caused by amiodarone is closely related to endoplasmic reticulum stress, and endoplasmic reticulum stress can be a potential therapeutic target for the treatment of destructive thyroiditis caused by amiodarone (Hanna et al 2021). Therefore, it is urgent to find out the mechanism of amiodarone-induced thyroid dysfunction.…”

Section: Introductionmentioning

confidence: 99%

MiR-214 inhibits apoptosis in thyroid epithelial follicular cells induced by amiodarone through the FASL/MAPK pathway

Wen

Deng

Shi

et al. 2021

Mol. Cell. Toxicol.

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Background Hashimoto's thyroiditis (HT), also known as chronic lymphocytic thyroiditis, is one of the most common autoimmune disease (AITD) in clinical practice. It is urgent to explore the mechanism of amiodarone-induced thyroid dysfunction. Objective This study aims to assess the expression levels of miR-214 and FasL in amiodarone contact type of HT, and the effect of miR-214 on cell viability and apoptosis and potential mechanism. ResultsWe found that miR-214 was low expressed in the tissues of amiodarone-treated thyroiditis patients. MiR-214 increased the survival rate of amiodarone-induced thyroid epithelial follicular cells and inhibited apoptosis. Mechanically, we found that miR-214 could bind to FASL and regulate MAPK signaling pathway through FASL. Conclusions Our results suggested that miR-214 could be a potential therapeutic target for Hashimoto's thyroiditis.

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The role of vitamin D receptor and IL‐6 in COVID‐19

Azmi

Rismani

Pourmontaseri

et al. 2023

Molec Gen & Gen Med

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Background Vitamin D (Vit.D) has an important role in protecting COVID‐19 patients. This study investigated the changes in vitamin D receptor (VDR) expression and interleukin 6 levels in patients with COVID‐19. Materials and methods 120 hospitalized patients and 120 healthy people participated in this study, both group adjusted by sex and age. Vit.D was measured with HPLC, the expression of VDR gene was done with Real‐time PCR, and IL‐6 was measured with ELISA assay. Results Our findings showed no significant difference in the case of Vit.D (25‐OH‐D3) between the two studied groups, interestingly the expression of VDR was statistically lower in the patients with COVID‐19, p‐value = 0.003. VDR expression was lower in the patient with diabetes, hypertension and cardiovascular disease, significantly, p‐value = 0.002. The level of IL‐6 was statistically higher in the COVID‐19 group, p‐value = 0.003. Conclusion Alongside the important role of 25‐OH‐D3 in COVID‐19 patients, the quality and quantity of the VDR expression and its role in the level of IL‐6 are the promising risk factors in the future. Further studies are needed to determine the factors increasing the expression level of VDR, especially in the patients with diabetes, hypertension and cardiovascular disease.

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Vitamin D status in Hashimoto’s thyroiditis and its association with vitamin D receptor genetic variants

Cited by 11 publications

References 24 publications

Genetic polymorphisms of vitamin D receptor gene and the risk of Hashimoto's thyroiditis: an Iraqi case-control study

Genetic polymorphisms of vitamin D receptor gene and the risk of Hashimoto's thyroiditis: an Iraqi case-control study

MiR-214 inhibits apoptosis in thyroid epithelial follicular cells induced by amiodarone through the FASL/MAPK pathway

The role of vitamin D receptor and IL‐6 in COVID‐19

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