Vitamin D Status in Mothers and Their Newborns and Its Association with Pregnancy Outcomes: Experience from a Tertiary Care Center in Northern India

Arora, Satyam; Goel, Poonam; Chawla, Deepak; Huria, Anju; Arya, Adhi

doi:10.1007/s13224-017-1067-3

Cited by 29 publications

(30 citation statements)

References 16 publications

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“…13 However, studies from North India have shown higher rates. 8,14 According to the study done by Arora et al, the prevalence was 95.5% and similar rate of 93.5% was reported by Sharma et al This is probably due to the difference in the amount of sunshine between the two parts of the country.…”

Section: Resultssupporting

confidence: 61%

“…7 Prevalence of 95-97% has been reported in the studies done in North India. 8 Current guidelines from WHO does not recommend vitamin D supplementation to improve maternal and perinatal outcomes but suggest supplementation of 200 IU per day in those with documented vitamin D deficiency. 9 Aim was to estimate the prevalence of vitamin D deficiency in pregnant women and their infants in South India.…”

Section: Introductionmentioning

confidence: 99%

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Vitamin D status of pregnant women and their infants in South India: VIPIS study

Navaneethan¹,

Mani²,

Shrestha³

et al. 2019

Int J Reprod Contracept Obstet Gynecol

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Background: Aim was to estimate the prevalence of vitamin D deficiency in pregnant women and their infants and to analyse the effect of maternal vitamin D deficiency on the infant.Methods: A prospective study was done in the Department of Obstetrics and Neonatology in a tertiary centre in South India with 150 women seen in the antenatal clinic after 36 weeks of pregnancy were recruited. Serum vitamin D levels were obtained. Babies were followed up and sampled once between 10 and 20 weeks of age for vitamin D, calcium, phosphate and alkaline phosphatase. Vitamin D levels less than 20 ng/ml was considered as deficiency. Analysis of the data was done using SPSS 16.0 version.Results: Vitamin D deficiency was seen in 64.8% of the pregnant women. Follow up of 76 babies showed vitamin D deficiency in 72.6% infants. Significantly high levels of alkaline phosphatase were noted in infants who were born to mothers with vitamin D deficiency, which indicates risk of developing bone disease.Conclusions: This study highlights the high prevalence of Vitamin D deficiency in pregnant women and their infants in South India in a region with abundant sunshine. This study also emphasises treating vitamin D deficiency in pregnancy to reduce the risk of developing rickets in infancy.

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Section: Resultssupporting

confidence: 61%

Section: Introductionmentioning

confidence: 99%

Vitamin D status of pregnant women and their infants in South India: VIPIS study

Navaneethan¹,

Mani²,

Shrestha³

et al. 2019

Int J Reprod Contracept Obstet Gynecol

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“…Several lines of evidence suggest that there is a strong association between maternal 25(OH)D levels during pregnancy and newborn 25(OH)D concentrations at birth or in the early neonatal period [238][239][240][241][242]. Novakovic et al reported that maternal circulating 25(OH)D levels were the most significant regulator of neonatal circulating vitamin D concentrations, even over the impact of genetic factors [243].…”

Section: The Association Of Maternal Vitamin D Status and Child Vitammentioning

confidence: 99%

Maternal Vitamin D Status among Different Ethnic Groups and Its Potential Contribution to Adverse Pregnancy and Child Outcomes

Keshavarz¹,

Jandaghi²,

Shafiee³

et al. 2020

Vitamin D Deficiency

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Maternal vitamin D deficiency in pregnancy is a widespread public health concern. Race and ethnicity as biological and cultural factors, respectively, can affect vitamin D status through differences in skin color, sunlight exposure, and dietary intake. Low maternal vitamin D status in pregnancy may affect both mother and fetus adversely. Vitamin D deficiency and insufficiency are linked to a wide variety of adverse pregnancy outcomes such as gestational diabetes, preeclampsia, and preterm delivery. Furthermore, maternal vitamin D deficiency has been linked to several adverse health outcomes in infants and children. The examples include, but not limited to, impaired growth, skeletal problems, and autoimmune diseases such as type 1 diabetes and asthma. This chapter reviews the vitamin D status during pregnancy across different ethnic groups, looking into the adverse pregnancy and child outcomes, followed by a discussion on the association between maternal and child vitamin D status and successful interventions. Strong evidence exists about the association between vitamin D and some health outcomes during pregnancy, while more studies are needed to confirm the other claim. The existing body of evidence justifies the need for well-designed policies and systematic interventions to ensure optimal vitamin D status of pregnant women and their offsprings across different ethnic and racial groups.

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“…Worldwide, pregnant women are reported to have inadequate 25‐hydroxyvitamin D [25(OH)D] levels . In India, the prevalence of maternal vitamin D deficiency is high , where 96% are reported to have 25(OH)D levels <20 ng/mL while 60% are reported to have <12 ng/mL levels . Recent studies indicate that maternal vitamin D deficiency is linked to pregnancy complications and adverse outcome like preeclampsia , preterm birth , and intrauterine growth restriction .…”

Section: Introductionmentioning

confidence: 99%

Maternal vitamin D deficiency increases the thromboxane/prostacyclin ratio through alterations in the one‐carbon cycle in Wistar rats

2019

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This study aims to test the hypothesis that vitamin D deficiency can influence long‐chain polyunsaturated fatty acid metabolism through alterations in the one‐carbon cycle. Wistar rats (n = 8 per group) were given either a control (1,000 IU D3/kg diet) or a vitamin D deficient (VDD) (0 IU D3/kg diet) diet from pre‐pregnancy to delivery. On day 20 of gestation, pregnant female rats were delivered by C‐section to collect placenta and blood. VDD group demonstrated high serum parathyroid hormone, low serum phosphate, low plasma folate, higher plasma homocysteine, and higher plasma malondialdehyde levels (P < 0.05 for all) as compared to control. Lower protein levels of placental cystathionine‐β‐synthase enzyme (P < 0.05) were observed in the VDD group as compared to control. VDD group demonstrated higher placental mRNA levels of the enzymes phospholipase A2 and cyclooxygenase‐2 (P < 0.05 for both) as compared to control. Protein levels of the enzymes phospholipase A2 and cyclooxygenase‐2 were lower (P < 0.05 for both) in the VDD group as compared to the control group. The ratio of thromboxane B2 and 6‐keto prostaglandin F1α in serum was higher (P < 0.05) in the VDD group as compared to control; although the serum levels of 6‐keto prostaglandin F1α and thromboxane B2 were similar in both the groups. Our findings suggest that increased oxidative stress due to maternal vitamin D deficiency results in the imbalance between the vasoconstrictor (thromboxane B2) and vasodilator (6‐keto prostaglandin F1α) eicosanoids, which may lead to endothelial dysfunction and poor pregnancy outcome. © 2019 BioFactors, 45 (4):548–555, 2019

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Vitamin D Status in Mothers and Their Newborns and Its Association with Pregnancy Outcomes: Experience from a Tertiary Care Center in Northern India

Abstract: This study showed a very high prevalence of hypovitaminosis D among pregnant women and excellent correlation between maternal and fetal 25(OH) D levels. Hypovitaminosis D was associated with preeclampsia, increased Cesarean rate, and low birth weight babies.

Cited by 29 publications

References 16 publications

Vitamin D status of pregnant women and their infants in South India: VIPIS study

Vitamin D status of pregnant women and their infants in South India: VIPIS study

Maternal Vitamin D Status among Different Ethnic Groups and Its Potential Contribution to Adverse Pregnancy and Child Outcomes

Maternal vitamin D deficiency increases the thromboxane/prostacyclin ratio through alterations in the one‐carbon cycle in Wistar rats

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