Vitamin D status in patients with systemic lupus erythematosus (SLE): A systematic review and meta-analysis

Immunomodulatory Effects of Diet and Nutrients in Systemic Lupus Erythematosus (SLE): A Systematic Review

“…Although vitamin D deficiency was insignificantly correlated with higher SLEDAI scores in Egyptian patients with juvenile-onset SLE ( 145 ), it was later suggested that vitamin D supplementation was effective for a significant reduction of SLEDAI ( p = 0.01) and improving fatigue ( p = 0.008) in Brazilian patients with juvenile-onset SLE ( 146 ). It was observed from two recent meta-analyses that the serum levels of vitamin D were significantly low ( p < 0.00001) in patients with SLE compared with those of healthy controls ( 147 ), and vitamin D supplementation was significantly effective ( p < 0.001) in increasing these low serum vitamin D levels in patients with SLE with improved fatigue ( 148 ). In a group of patients with SLE, levels of mTOR mRNA were higher in a group with severe vitamin D deficiency compared with a group with vitamin D insufficiency ( p = 0.036) indicating that severe vitamin D deficiency contributes to SLE pathogenesis via increased expression of mTOR ( 149 ).…”

Pathophysiological Role and Therapeutic Implications of Vitamin D in Autoimmunity: Focus on Chronic Autoimmune Diseases

“…Vitamin D deficiency has been observed to be associated with SLE disease expression, relapses, and pathogenesis [86,87]. Systematic reviews and meta-analyses have been published on the significance of lower circulating levels of vitamin D in patients with SLE of different ethnicity when compared to healthy controls [88][89][90]. In particular, vitamin D status inadequacy was more prevalent among unsupplemented SLE patients living at a latitude beyond the 37 • parallel north and [88].…”

“…Systematic reviews and meta-analyses have been published on the significance of lower circulating levels of vitamin D in patients with SLE of different ethnicity when compared to healthy controls [88][89][90]. In particular, vitamin D status inadequacy was more prevalent among unsupplemented SLE patients living at a latitude beyond the 37 • parallel north and [88]. The reduced sun exposure due to photosensitivity and the use of photo-protection, as well as the alteration of its renal metabolism, the presence of VDR polymorphisms which reduce the cell responsiveness to the hormone or the genetic variants of two genes encoding key enzyme regulators of endogenous production, were all described as additional risk factors for vitamin D insufficiency in SLE patients as compared to healthy controls [91,92].…”

“…Despite the debate about low levels of vitamin D being either the cause or the consequence of SLE [105], vitamin D supplementation should be deemed as integral part of SLE management strategies [88].…”

Low serum 25‐hydroxyvitamin D3 levels and late delayed radiation‐induced brain injury in patients with nasopharyngeal carcinoma: A case–control study

“…are associated with a variety of immune disorders such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and autoimmune thyroid diseases (Harrison et al, 2020;Islam et al, 2019;Lee et al, 2019). Moreover, vitamin D is independent risk factor for CNS demyelination including multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), and inflammatory spinal cord disease (Mealy et al, 2012;Salzer et al, 2012;Shan et al, 2016).…”