Vitamin D Supplementation and Non-Alcoholic Fatty Liver Disease: Present and Future

Barchetta, Ilaria; Cimini, Flavia Agata; Cavallo, Maria Gisella

doi:10.3390/nu9091015

Cited by 62 publications

(25 citation statements)

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“…Several observational studies reported a link between low 25(OH)D plasma levels and fatty liver diseases [13,[47][48][49]. If the causality is still not clearly demonstrated in humans [50], observations on animal models, including the present study, tend to confirm such an assumption.…”

Section: Discussionsupporting

confidence: 56%

Vitamin D Supplementation Improves Adipose Tissue Inflammation and Reduces Hepatic Steatosis in Obese C57BL/6J Mice

et al. 2020

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The beneficial effect of vitamin D (VD) supplementation on body weight gain limitation and inflammation has been highlighted in primary prevention mice models, but the long-term effect of VD supplementation in tertiary prevention has never been reported in obesity models. The curative effect of VD supplementation on obesity and associated disorders was evaluated in high-fat- and high-sucrose (HFS)-fed mice. Morphological, histological, and molecular phenotype were characterized. The increased body mass and adiposity caused by HFS diet as well as fat cell hypertrophy and glucose homeostasis were not improved by VD supplementation. However, VD supplementation led to a decrease of HFS-induced inflammation in inguinal adipose tissue, characterized by a decreased expression of chemokine mRNA levels. Moreover, a protective effect of VD on HFS-induced hepatic steatosis was highlighted by a decrease of lipid droplets and a reduction of triglyceride accumulation in the liver. This result was associated with a significant decrease of gene expression coding for key enzymes involved in hepatic de novo lipogenesis and fatty acid oxidation. Altogether, our results show that VD supplementation could be of interest to blunt the adipose tissue inflammation and hepatic steatosis and could represent an interesting nutritional strategy to fight obesity-associated comorbidities.

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Section: Discussionsupporting

confidence: 56%

Vitamin D Supplementation Improves Adipose Tissue Inflammation and Reduces Hepatic Steatosis in Obese C57BL/6J Mice

et al. 2020

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“…9, 10-Secoergosta-7, 10 (19), 22-triene-3, 5, 6-triol is one form of dehydrocalciferol from vitamin D 31 . Hydroxyvitamin D form in the body will affect the health of a human's liver 32 .…”

Section: Gracilismentioning

confidence: 99%

Untitled

2019

IJPSR

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Dipterocarpus gracilis Blume is one tropical species of Dipterocarps which is included in the red list IUCN as a rare and endangered tree species. In consideration of Dipterocarpus gracilis Blume conservation and sustainability of its oleoresin, this present study aimed to determine specific characteristics of oleoresin origin of Dipterocarpus gracilis Blume as an establishing basis for appropriate product diversification of human remedy. Here, is also evaluated the presence of different phytochemical along with GC-MS investigations of water and ethanol soluble crude extracts, and anti-oxidant obtained in oleoresin. The results showed that oleoresin of Dipterocarpus gracilis Blume revealed the presence of alkaloid and triterpenoid, whereas antioxidant activity test had low in 95% ethanol soluble. While, GC-MS analysis of organic compound of oleoresin of Dipterocarpus gracilis Blume identified that the most organic compound such as Caryophyllene, Caryophyllene oxide,

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“…Vitamin D knockout mice spontaneously developed liver fibrosis, while mice fed a vitamin D‐deficient diet developed severe hepatic steatosis and inflammation,82, 83 demonstrating that NAFLD may be associated with vitamin D deficiency. However, clinical studies on vitamin D supplementation on NAFLD pathogenesis have been limited; thus, more studies are needed to provide conclusive results 84. On the other hand, studies have shown that PXR can activate de novo lipogenesis in an SREPB1c‐dependent manner.…”

Section: Nuclear Receptors As Therapeutic Targetsmentioning

confidence: 99%

Nuclear receptors and liver disease: Summary of the 2017 basic research symposium

Tran

Liu

Huang

et al. 2018

Hepatology Communications

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The nuclear receptor superfamily contains important transcriptional regulators that play pleiotropic roles in cell differentiation, development, proliferation, and metabolic processes to govern liver physiology and pathology. Many nuclear receptors are ligand‐activated transcription factors that regulate the expression of their target genes by modulating transcriptional activities and epigenetic changes. Additionally, the protein complex associated with nuclear receptors consists of a multitude of coregulators, corepressors, and noncoding RNAs. Therefore, acquiring new information on nuclear receptors may provide invaluable insight into novel therapies and shed light on new interventions to reduce the burden and incidence of liver diseases. (Hepatology Communications 2018;2:765‐777)

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Vitamin D Supplementation and Non-Alcoholic Fatty Liver Disease: Present and Future

Cited by 62 publications

References 62 publications

Vitamin D Supplementation Improves Adipose Tissue Inflammation and Reduces Hepatic Steatosis in Obese C57BL/6J Mice

Vitamin D Supplementation Improves Adipose Tissue Inflammation and Reduces Hepatic Steatosis in Obese C57BL/6J Mice

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Nuclear receptors and liver disease: Summary of the 2017 basic research symposium

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