Vitamin D supplementation for women during pregnancy

De-Regil, Luz María; Palacios, Cristina; Ansary, Ali; Kulier, Regina; Peña-Rosas, Juan Pablo

doi:10.1002/14651858.cd008873.pub2

Cited by 190 publications

(203 citation statements)

References 128 publications

(172 reference statements)

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“…In contrast, Cadario et al [35] reported that all mothers supplemented with vitamin D (who used daily a standard prenatal multivitamin containing 400 IU of vitamin D) demonstrated higher 25(OH)D 3 values in neonatal serum. Similarly, a systematic review during pregnancy showed that with supplementation there is an increase of serum 25(OH)D 3 levels in neonates [36]. …”

Section: Discussionmentioning

confidence: 99%

Association between Serum 25-Hydroxyvitamin D Levels and TTN

Konca

Kahramaner²,

Bülbül³

et al. 2014

Horm Res Paediatr

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Aim: To investigate the association between serum 25-hydroxyvitamin D (25(OH)D₃) levels and transient tachypnea of the newborn (TTN). Methods: Calcium (Ca), phosphorus (P), alkaline phosphatase (ALP), parathormone (PTH) and serum 25(OH)D₃ levels were measured in 51 infants diagnosed with TTN and 59 healthy control infants for comparison. Demographic factors including gestational age, birth weight, gender, delivery mode, parity, vitamin D supplementation during pregnancy and severity of TTN were recorded. Results: The serum levels of 25(OH)D₃ were significantly lower in infants with TTN compared to infants with no respiratory distress (p < 0.01). There was no statistically significant difference in serum Ca, P and ALP levels between the groups while the serum levels of PTH were significantly higher in the study group (p < 0.01). No correlation was found between the serum 25(OH)D₃ levels and severity of TTN. Vitamin D supplementation (400 IU/day) during pregnancy did not affect the serum levels of newborns. Conclusion: Our data suggests that lower 25(OH)D₃ serum levels are associated with an increased risk of TTN and vitamin D may have a role in the pathogenesis of TTN.

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Section: Discussionmentioning

confidence: 99%

Association between Serum 25-Hydroxyvitamin D Levels and TTN

Konca

Kahramaner²,

Bülbül³

et al. 2014

Horm Res Paediatr

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“…Maternal vitamin D deficiency, especially in early pregnancy, has been associated with risk of preeclampsia, preterm birth and small-for-gestational-age (SGA) infants [52,53]. A systematic review of vitamin D in pregnancy showed an overall reduction in LBW of borderline significance [53]. …”

Section: Maternal Micronutrient Deficiency: Burden Significance and mentioning

confidence: 99%

Multiple Micronutrient Supplementation during Pregnancy and Lactation in Low-to-Middle-Income Developing Country Settings: Impact on Pregnancy Outcomes

Salam¹,

Das²,

Bhutta³

2014

Ann Nutr Metab

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Background: Malnutrition, including micronutrient deficiencies, remains one of the major public health challenges, particularly in low-to-middle-income countries. Micronutrient deficiencies affect people of all ages, but its effects appear more devastating in pregnant women and children. Poor maternal nutrition contributes to at least 20% of maternal deaths and increases the probability of poor pregnancy outcomes including intrauterine growth restriction, resulting in low birth weight, stunting, wasting and mortality. Key Messages: Several strategies have been employed to provide pregnant women with micronutrients. These strategies include education, dietary modification, food provision, agricultural interventions, supplementation and fortification either alone or in combination. Micronutrient supplementation is the most widely practiced intervention to prevent and manage single or multiple micronutrient deficiencies. Micronutrient supplementation either alone or in combination has shown to be effective in improving maternal, birth and child outcomes. Conclusions: There is a need to focus on maternal micronutrient status as a continuum from the periconceptional period throughout pregnancy to lactation. Given the wide prevalence of multiple micronutrient deficiencies in low-to-middle-income countries, the challenge is to implement intervention strategies that combine appropriate maternal and child health interventions with micronutrient interventions.

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“…Measuring VD insufficiency in pregnant women is complicated by a lack of agreement in some aspects, such as the accuracy of 25(OH)D levels as marker of deficiency, normal VD levels in pregnancy, and the identification of gold standard test for VD deficiency [14]. 25(OH)D is the clinical and research gold standard measure of VD status [15].…”

Section: Identifying Vitamin D Deficiencymentioning

confidence: 99%

“…For that reason, the clinical significance of vitamin D supplementation as a part of routine antenatal care must be considered. Supplementation studies conducted with recommended daily allowance of 400 IU have not shown any improvement in vitamin D status of pregnant women [14]. Higher doses given as a daily dose of 800 IU or bolus dose of 200,000 IU given as a single dose or 2/3 divided doses given once a month have shown significant improvement [14].…”

Section: Treating Vitamin D Deficiency In Pregnancymentioning

confidence: 99%

Potential impact of maternal vitamin D status on obstetric well-being

Triunfo

Lanzone

2015

J Endocrinol Invest

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Despite its discovery 100 years ago, vitamin D (VD) has emerged as one of the most controversial nutrients and prohormones of the 21st century. In the past few years, a growing interest in VD has been observed in the biomedical literature due to evidences demonstrating a relevant relationship not only between regulation of calcium and phosphorus homeostasis, but also multiple disease states and low VD status in the population. Indeed, several studies carried out to decipher its role in the body in almost every cell, tissue, and different organs. Recent findings suggested a significant implication of VD in different physiologic processes , such as vascular health, immune function, metabolism, and placental function. In the attempt to focus the attention on effect of VD on female reproductive health, there has been a paucity of data from randomized controlled trials to establish clear beneficial. Human and animal data suggest that low VD status is associated with impaired fertility, endometriosis, and polycystic ovary syndrome. Findings from observational studies show higher rates of preeclampsia, gestational diabetes, preterm birth, and bacterial vaginosis in women with low VD levels. By recent evidences, this review explored the association between maternal VD status and selected effects on maternal, perinatal, and infant health, and the impact of VD supplementation during pregnancy on obstetric well-being.

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Vitamin D supplementation for women during pregnancy

Cited by 190 publications

References 128 publications

Association between Serum 25-Hydroxyvitamin D Levels and TTN

Association between Serum 25-Hydroxyvitamin D Levels and TTN

Multiple Micronutrient Supplementation during Pregnancy and Lactation in Low-to-Middle-Income Developing Country Settings: Impact on Pregnancy Outcomes

Potential impact of maternal vitamin D status on obstetric well-being

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