Vitamin D Supplementation in Adults with Vitamin D Deficiency and Its                     Effect on Metabolic Syndrome – A Randomized Controlled Study

Mahmood, Saba Fathima; Idiculla, Jyothi; Joshi, Rajnish; Joshi, Saurabh; Kulkarni, Subhash

doi:10.1024/0300-9831/a000426

Cited by 15 publications

(28 citation statements)

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“…Eight of them showed no difference in BMI after the intervention Frontiers in Pharmacology frontiersin.org compared to baseline values in the experimental group. Only 1 trail showed a significant reduction after VDS treatment (Mahmood et al, 2016). Meanwhile, 2 trails also assessed WHR (Salekzamani et al, 2016;Shidfar et al, 2019).…”

Section: Results Of the Included Rctsmentioning

confidence: 99%

“…The assessment results of the bias risk in the included RCTs are shown in Figure 2. According to the Cochrane criteria, the Frontiers in Pharmacology frontiersin.org Mahmood et al, 2016;Salekzamani et al, 2016;Maktabi et al, 2017;Pragya et al, 2021), while this was unclear in the other studies. Blinding of participants was not clear in 4 trails (Farag et al, 2019;Corcoy et al, 2020;Imanparast et al, 2020;Cojic et al, 2021), since they did not mention the randomization method.…”

Section: Assessment Of Bias Riskmentioning

confidence: 99%

“…The association between VDS and MetS is controversial. The benefits of VDS in the treatments of MetS and its disorders connected include improved arterial stiffness, mitochondrial oxidation and phospholipid metabolism; increased lipoprotein lipase activity, peripheral insulin sensitivity and β -cell function; decreased inflammatory cytokines and parathyroid hormone levels, and renin-angiotensin-aldosterone system activity ( Mahmood et al, 2016 ; Teixeira et al, 2018 ; Chen et al, 2019 ; Ferreira et al, 2020 ; Xu et al, 2020 ). Zhu and Heil reported that serum 25-hydroxyvitamin D (25(OH)D) level was linked to the risk factors for MetS, and that 1 ng/ml rise in serum 25(OH)D level was related with a considerable decrease in TC and LDL, as well as a 54% reduction in the risk of MetS ( Zhu and Heil, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

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The impacts of vitamin D supplementation in adults with metabolic syndrome: A systematic review and meta-analysis of randomized controlled trials

Zhang

et al. 2022

Front. Pharmacol.

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Background: Studies have shown the association of vitamin D status with the development of metabolic syndrome (MetS), which has attracted an extensive research interest with inconsistent results. Therefore, we hypothesized that vitamin D supplementation (VDS) will benefit adults with MetS.Aims: To test our hypothesis, we performed a meta-analysis to evaluate the effect of VDS on MetS in adults using relevant biomarkers such as anthropometric parameters, blood pressure, blood lipid profile, glycemia, oxidative stress and vitamin D toxicity (VDT).Methods: Randomized controlled trials published in PubMed, Web of Science, embase and the Cochrane Library between 2012 and 2022 on the effect of VDS on MetS in adults were searched. The language was limited to English. A meta-analysis performed using RevMan 5.4 and Stata 14.0 software, sensitivity analysis, and evaluation of the risk of bias and general quality of the resulting evidence were conducted.Results: Eventually, 13 articles were included in this meta-analysis. Overall, VDS significantly increased the endline serum 25-hydroxyvitamin D levels as compared to the control [MD:17.41, 95% CI (14.09, 20.73), p < 0.00001]. VDS did not affect waist circumference, body mass index, body fat percentage and VDT biomarkers, but decreased waist-to-hip ratio and blood pressure (p < 0.01). VDS significantly decreased fasting plasma glucose (FPG) [MD: 3.78; 95% CI (−6.52, −1.03), p = 0.007], but did not affect the levels of blood high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and triglyceride (TG). Pooled estimate of nine papers indicated a significant reduction of fasting insulin (FI) (p = 0.006), and homeostasis model assessment of insulin resistance (p = 0.0001). The quantitative insulin check index levels were moderately increased (p = 0.007) without any impact on the glycosylated hemoglobin type A1C (HbA1c). For the oxidative stress parameters, VDS significantly lowered the levels of malondialdehyde and hypersensitive C-reactive protein (p < 0.05).Conclusion: Results of this meta-analysis demonstrate that VDS only reduces insulin resistance and hypertension but not the blood lipid profile and HbA1c. It appears that the evidence for the benefit of VDS in adults with MetS is inconclusive. Further clinical studies are still needed.

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Section: Results Of the Included Rctsmentioning

confidence: 99%

Section: Assessment Of Bias Riskmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The impacts of vitamin D supplementation in adults with metabolic syndrome: A systematic review and meta-analysis of randomized controlled trials

Zhang

et al. 2022

Front. Pharmacol.

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“…The controversy regarding the vitamin D–metabolic syndrome–insulin resistance relationship is an open and much-debated issue. Some studies do not seem to support this hypothesis, unlike others [ 40 , 41 ]. Recently, in a double-blind, randomized clinical trial (RCT) [ 41 ], albeit on a modest sample (44 patients enrolled for 3 months), insulin resistance, glucose homeostasis, and metalloproteases (MMP-9) were evaluated in obese subjects (BMI: 30–40 kg/m 2 ) with a deficiency of vitamin D (25 (OH)-D: ≤50 nmol/L; ≤20 ng/mL) in which, with double-blind randomization, a high dose of vitamin D3 (50,000 U/week) was administered for 3 months together with a weight loss diet.…”

Section: Role Of Vitamin D In Diabetes Mellitus Metabolic Syndrome and Obesitymentioning

confidence: 86%

Vitamin D: Not Just Bone Metabolism but a Key Player in Cardiovascular Diseases

Izzo

Carrizzo

Izzo

et al. 2021

Life

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Vitamin D is the first item of drug expenditure for the treatment of osteoporosis. Its deficiency is a condition that affects not only older individuals but also young people. Recently, the scientific community has focused its attention on the possible role of vitamin D in the development of several chronic diseases such as cardiovascular and metabolic diseases. This review aims to highlight the possible role of vitamin D in cardiovascular and metabolic diseases. In particular, here we examine (1) the role of vitamin D in diabetes mellitus, metabolic syndrome, and obesity, and its influence on insulin secretion; (2) its role in atherosclerosis, in which chronic vitamin D deficiency, lower than 20 ng/mL (50 nmol/liter), has emerged among the new risk factors; (3) the role of vitamin D in essential hypertension, in which low plasma levels of vitamin D have been associated with both an increase in the prevalence of hypertension and diastolic hypertension; (4) the role of vitamin D in peripheral arteriopathies and aneurysmal pathology, reporting that patients with peripheral artery diseases had lower vitamin D values than non-suffering PAD controls; (5) the genetic and epigenetic role of vitamin D, highlighting its transcriptional regulation capacity; and (6) the role of vitamin D in cardiac remodeling and disease. Despite the many observational studies and meta-analyses supporting the critical role of vitamin D in cardiovascular physiopathology, clinical trials designed to evaluate the specific role of vitamin D in cardiovascular disease are scarce. The characterization of the importance of vitamin D as a marker of pathology should represent a future research challenge.

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“…For example, some studies have shown an inverse association between the incidence of MetS and serum vitamin D levels [17][18][19][20], while others have failed to find such an association [21][22][23][24][25]. Furthermore, the association between vitamin D status and MetS was observed mostly in cross-sectional studies, but not in the clinical trial [ 26] or in longitudinal studies [ 27,28].…”

Section: Introductionmentioning

confidence: 99%

Association between vitamin D status and metabolic syndrome in a longitudinal study of Iranian adults

Khosravi-Boroujeni

Sarrafzadegan²,

Sadeghi

et al. 2019

Preprint

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Background In recent years, hypovitaminosis D has been linked to many chronic diseases, including metabolic syndrome (MetS). However, there are considerable discrepancies in the study findings. Therefore, the present study investigated the association between vitamin D status and MetS in a cohort of Iranian adults followed from 2001 to 2013. Method This study was designed using the data from Isfahan cohort study which is an ongoing cohort of Iranian adults. For this study, 170 cases with MetS were selected from those who were free of MetS in 2001 but developed the condition in 2013. Controls (n=200) were selected from those who were free of MetS throughout the study period. Various biochemical parameters, including serum vitamin D concentrations, and socio-demographic information were assessed in 2001, 2007 and 2013. Generalized Estimating Equations was used to analyse the longitudinal association between vitamin D status and MetS. Results The subjects with MetS had higher levels of serum vitamin D [25(OH)D], total cholesterol, triglyceride, body mass index, waist circumference, systolic and diastolic blood pressure than that in the control subjects in 2001, while they had lower physical activity levels. A family history of hyperlipidemia was also more prevalent in the subjects with MetS. This study did not find any association between MetS and serum vitamin D status after controlling for potential confounders. Conclusion In spite of the high prevalence of vitamin D deficiency and MetS among studied population, this study failed to show any association between vitamin D status and MetS and/or its components. Randomized controlled trials are warranted to investigate the potential association more meticulously.

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Vitamin D Supplementation in Adults with Vitamin D Deficiency and Its Effect on Metabolic Syndrome – A Randomized Controlled Study

Abstract: In this study the relationship between vitamin D supplementation and MetS or IR was not established. Whether achieving vitamin D sufficiency in large population-based trials with a longer duration would produce more favorable results needs to be assessed.

Cited by 15 publications

References 0 publications

The impacts of vitamin D supplementation in adults with metabolic syndrome: A systematic review and meta-analysis of randomized controlled trials

The impacts of vitamin D supplementation in adults with metabolic syndrome: A systematic review and meta-analysis of randomized controlled trials

Vitamin D: Not Just Bone Metabolism but a Key Player in Cardiovascular Diseases

Association between vitamin D status and metabolic syndrome in a longitudinal study of Iranian adults

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