Vitamin D supplementation: position Statement of the Iberoamerican Society of Osteoporosis and Mineral Metabolism (SIBOMM)

Palacios, Santiago; Cerdas, Sonia; Silva, Ramiro Da; Paradas, Alejandro; Vargas, Jorge; Mostajo, Desireé; Tserotas, Konstantinos; Danckers, Luis; Moreno, Mario; Navas, María Jesús López; Muñoz-Louis, Roberto; Maida, Tatiana; Rosero, Oscar; Rueda, Camilo; Vásquez, David; Melo, Luciano Cavalheiro; Córdoba, Santiago Rodrı́guez de; Rasec-Morales, Luis; Melo, Nilson Roberto de

doi:10.1080/09513590.2020.1858781

Cited by 5 publications

(7 citation statements)

References 23 publications

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“…The search initially yielded 7,874 records, and 24 guidelines and consensuses were finally included, 12 guidelines were evidence-based, four were non-evidence-based, and eight were consensus, all of which were developed by local or international medical societies. One guideline ( 11 ) was globally developed, and the others were developed in 12 different countries and regions, including China ( 4 , 5 , 12 , 13 ), the USA ( 14 – 16 ), Europe ( 17 – 19 ), India ( 20 ), Australia and New Zealand ( 21 , 22 ), the United Arab Emirates ( 23 ), France ( 24 , 25 ), Canada ( 26 ), Poland ( 27 ), Italy ( 28 ), Germany ( 29 , 30 ), and Latin America ( 31 ). Figure 1 shows the flow diagram of the study selection process.…”

Section: Resultsmentioning

confidence: 99%

“…Figure 1 shows the flow diagram of the study selection process. Studies were published (or updated) from 2002 to 2022, of which 12 guidelines were evidence-based guidelines ( 11 , 13 , 15 , 18 , 20 – 22 , 25 – 28 , 31 ), four were non-evidence-based guidelines ( 14 , 23 , 24 , 32 ), and eight were consensus guidelines ( 4 , 5 , 12 , 16 , 17 , 19 , 29 , 30 ). A summary of the characteristics of the included guidelines and consensuses is presented in Table 1 .…”

Section: Resultsmentioning

confidence: 99%

“…A total of three calcium supplementation guidelines and consensuses ( 4 , 21 , 30 ), 17 VD supplementation guidelines and consensuses ( 5 , 12 , 13 , 15 – 18 , 20 , 22 – 24 , 26 – 29 , 31 , 32 ), and four calcium and VD supplementation guidelines were included ( 11 , 14 , 19 , 25 ). These sources recommended preventive or upper limit doses and serum 25(OH)D levels for healthy children of different ages; details on the preventive dose, upper limit dose, choice of VD2 or VD3 supplements, sunlight exposure suggestion, and serum 25(OH)D levels are shown in Supplementary materials 3 , 4 .…”

Section: Resultsmentioning

confidence: 99%

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Evaluation of the clinical practice guidelines and consensuses on calcium and vitamin D supplementation in healthy children using the Appraisal of Guidelines for Research and Evaluation II instrument and Reporting Items for Practice Guidelines in Healthcare statement

Zhou

et al. 2022

Front. Nutr.

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BackgroundThis study aimed to assess the methodological and reporting quality of the guidelines and consensus on calcium and vitamin D supplementation in healthy children, and the consistency of these recommendations.MethodsA systematic search of relevant guideline websites and databases, including PubMed, Embase, CNKI, WangFang, and SinoMed, was undertaken from inception to April 7, 2021, by two independent reviewers who assessed the eligible guidelines using the validated Appraisal of Guidelines for Research and Evaluation Instrument II (AGREE II) and the Reporting Items for Practice Guidelines in Healthcare (RIGHT) tools. Overall, the between-reviewer agreement was evaluated using an intra-class correlation coefficient.ResultsA total of 24 guidelines and consensuses from 2002 to 2022 were identified from China, the United States, Canada, France, Australia, New Zealand, Europe, and other countries and regions. These were of mixed quality, and scored poorly in the rigor of development, editorial independence, and applicability of the domains of AGREE II. Among the seven domains of the RIGHT checklist, domain one (basic information) had the highest reporting rate (69.3%), whereas domain five (review and quality assurance) had the lowest reporting rate (11.5%). The overall quality of the included guidelines and consensuses was low. Only 12 guidelines were recommended, with modifications. The recommended calcium intake for children of different ages varies greatly (400–1,150 mg/day). Among the included guidelines and consensuses, a vitamin D (VD) prevention dose of 400 IU/day in infants was generally considered safe, and 25-hydroxyvitamin-D [25(OH)D] levels of <20 ng/mL (50 nmol/L) or 20–30 ng/mL (50–75 nmol/L) indicated VD deficiency or insufficiency. However, the recommended amount of VD for children of different age groups and risk strata differed considerably (400–4,000 IU/day or 10–100 μg/day). The choice of VD2 or VD3 supplements and sunlight exposure also differed across the guidelines and consensuses.ConclusionThere is considerable variability in calcium and VD guidelines and consensus development methods in calcium and VD supplementation for healthy children. Therefore, efforts are necessary to strengthen the methodological rigor of guideline development and utilize the best available evidence to underpin recommendations.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Evaluation of the clinical practice guidelines and consensuses on calcium and vitamin D supplementation in healthy children using the Appraisal of Guidelines for Research and Evaluation II instrument and Reporting Items for Practice Guidelines in Healthcare statement

Zhou

et al. 2022

Front. Nutr.

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“…Many individuals have difficulty meeting their daily vitamin D requirements through food intake and being outside in the sun. It is thus important to highlight the need for vitamin D supplementation [ 30 ]. Several studies have reported a link between vitamin D deficiency and an increased risk of acquiring several types of inflammatory diseases.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D ameliorates insulin resistance-induced osteopenia by inactivating the nucleotide-binding oligomerization domain-like receptor protein 3 inflammasome

Wu¹,

Cai²,

Yang³

et al. 2023

Heliyon

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“…It is worth noting that vitamin D thresholds are not always intended to be diagnostic but are indicative of increased risk of disease. Based on these definitions, the prevalence of vitamin D deficiency/insufficiency worldwide is substantial irrespective of geographical region, ethnicity, latitude or altitude [3,5,[27][28][29][30][31][32][33][34][35]. Indeed, a large systematic review found that 88% of the worldwide population had serum 25(OH)D concentrations < 75 nmol/L, 37% had concentrations < 50 nmol/L and 7% had concentrations < 25 nmol/L [3].…”

Section: Vitamin D Deficiencymentioning

confidence: 99%

Calcifediol: a review of its pharmacological characteristics and clinical use in correcting vitamin D deficiency

2023

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Background In addition to the role of vitamin D in bone mineralization, calcium and phosphate homeostasis, and skeletal health, evidence suggests an association between vitamin D deficiency and a wide range of chronic conditions. This is of clinical concern given the substantial global prevalence of vitamin D deficiency. Vitamin D deficiency has traditionally been treated with vitamin D 3 (cholecalciferol) or vitamin D 2 (ergocalciferol). Calcifediol (25-hydroxyvitamin D 3 ) has recently become available more widely. Methods By means of targeted literature searches of PubMed, this narrative review overviews the physiological functions and metabolic pathways of vitamin D, examines the differences between calcifediol and vitamin D 3 , and highlights clinical trials conducted with calcifediol in patients with bone disease or other conditions. Results For supplemental use in the healthy population, calcifediol can be used at doses of up to 10 µg per day for children ≥ 11 years and adults and up to 5 µg/day in children 3−10 years. For therapeutic use of calcifediol under medical supervision, the dose, frequency and duration of treatment is determined according to serum 25(OH)D concentrations, condition, type of patient and comorbidities. Calcifediol differs pharmacokinetically from vitamin D 3 in several ways. It is independent of hepatic 25-hydroxylation and thus is one step closer in the metabolic pathway to active vitamin D. At comparable doses to vitamin D 3 , calcifediol achieves target serum 25(OH)D concentrations more rapidly and in contrast to vitamin D 3 , it has a predictable and linear dose-response curve irrespective of baseline serum 25(OH)D concentrations. The intestinal absorption of calcifediol is relatively preserved in patients with fat malabsorption and it is more hydrophilic than vitamin D 3 and thus is less prone to sequestration in adipose tissue. Conclusion Calcifediol is suitable for use in all patients with vitamin D deficiency and may be preferable to vitamin D 3 for patients with obesity, liver disease, malabsorption and those who require a rapid increase in 25(OH)D concentrations.

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Vitamin D supplementation: position Statement of the Iberoamerican Society of Osteoporosis and Mineral Metabolism (SIBOMM)

Cited by 5 publications

References 23 publications

Evaluation of the clinical practice guidelines and consensuses on calcium and vitamin D supplementation in healthy children using the Appraisal of Guidelines for Research and Evaluation II instrument and Reporting Items for Practice Guidelines in Healthcare statement

Evaluation of the clinical practice guidelines and consensuses on calcium and vitamin D supplementation in healthy children using the Appraisal of Guidelines for Research and Evaluation II instrument and Reporting Items for Practice Guidelines in Healthcare statement

Vitamin D ameliorates insulin resistance-induced osteopenia by inactivating the nucleotide-binding oligomerization domain-like receptor protein 3 inflammasome

Calcifediol: a review of its pharmacological characteristics and clinical use in correcting vitamin D deficiency

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