Vitamin D supplementation: upper limit for safety revisited?

Rizzoli, René

doi:10.1007/s40520-020-01678-x

Cited by 78 publications

(56 citation statements)

References 71 publications

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“…Vitamin D in excess is associated with hypercalcemia, hypercalciuria and mineral deposits in soft tissues. However, doses of 800 IU to 1000 IU /day the for the prevention of Vitamin D deficiency is considered safe [102].…”

Section: Calcium and Vitamin Dmentioning

confidence: 99%

Pathophysiology and treatment of osteoporosis: challenges for clinical practice in older people

et al. 2021

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Osteoporosis, a common chronic metabolic bone disease is associated with considerable morbidity and mortality. As the prevalence of osteoporosis increases with age, a paralleled elevation in the rate of incident fragility fractures will be observed. This narrative review explores the origins of bone and considers physiological mechanisms involved in bone homeostasis relevant to management and treatment. Secondary causes of osteoporosis, as well as osteosarcopenia are discussed followed by an overview of the commonly used pharmacological treatments for osteoporosis in older people.

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Section: Calcium and Vitamin Dmentioning

confidence: 99%

Pathophysiology and treatment of osteoporosis: challenges for clinical practice in older people

et al. 2021

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“…the elderly, those of color, obese and those living > 45 o latitude. [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] • Vitamin C 500 mg BID (twice daily) and Quercetin 250 mg daily. [23][24][25][26][27][28][29][30][31][32][33][34] It is likely that vitamin C and quercetin have synergistic prophylactic benefit.…”

Section: Prophylaxismentioning

confidence: 99%

Summary of Contact With Dr. Marik. Pulmonary Medicine and Critical Care. Eastern Virginia Medical School - Usa.

Boni¹

2021

JLPPHS

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This brief note introduces the reproduction of medical content, authored by Doctor Paul E. Marik. Dr. Marik is Professor of Medicine and Chief of Pulmonary Medicine and Critical Care at Eastern Virginia Medical School in Norfolk, Virginia (USA). Dr. Marik is an extremely qualified and experienced professional. The reprinting of the material was authorized by Dr. Marik himself on 12/02/2020. This material is relevant in the Brazilian scenario due to standardized procedures for patients infected with the coronavirus. Only 1 of the 5 files kindly provided by the author, in PDF format, was selected and reproduced as received, without any editing. Due to the pandemic's long duration, the Journal editors (who are not medical doctors) have already had the opportunity to monitor the development of the disease in more than one infected person. The type of treatment offered to patients seems to influence the course, duration, and severity of the disease. The treatments described in the materials below appear to be effective and have good results. The editors will refrain from making additional comments on the proposed methods not to influence anyone, restricting themselves to suggesting that they be discussed with the reader's trusted doctor in case of need or doubts. Complete, updated information and also translated into Portuguese are available at . We are grateful to Dr. Marik for his kindness in giving us his time in this troubled period.

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“…There is in vitro proof that vitamin D is associated with insusceptible cell reactions to some popular and bacterial respiratory microorganisms. Some have theorized that individuals with low serum vitamin D may be at higher danger of contamination with COVID-19, or do more awful if infected [63]. Some have conjectured that individuals with low serum vitamin D may be at higher danger of disease with COVID-19, or do more awful whenever tainted.…”

Section: Evidence For Vitamin D's Role In Immunity and Infectionmentioning

confidence: 99%

Impact of Natural Products on Developing New Treatments for Corona Virus Disease (COVID-19): Review

Saddiq

Danial

Saraf

2021

JPRI

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COVID-19 is dominatingly considered as an unavoidable pandemic, and researchers are exceptionally inquisitive about how to give the best assurance to people in general before an immunization can be made accessible. Normal items have consistently assumed an essential part in drug advancement measure against different illnesses, which brought about screening of such specialists to battle emanant freaks of infections. Contingent upon the construction, component of activity and hazard elements of Covid-19, this audit centers around those normal mixtures that showed promising outcomes against Corona infections. Although restraint of viral replication is frequently considered as an overall component for antiviral action of many of the characteristic items, contemplates have shown that some regular items can connect with key viral proteins that are related with destructiveness. Supplementation of natural products might be a affect to reduce risk through different mechanisms. In this unique circumstance, a portion of the regular items have antiviral action in the nanomolar fixation and could be leads for additional medication advancement all alone or as a format for drug plan. Also, a decent number of normal items with against Covid action are the significant constituents of some regular dietary enhancements, which can be abused to improve the resistance of everyone in specific scourges The candidate compounds identified by us may help to speed up the drug development against COVID-19.

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Vitamin D supplementation: upper limit for safety revisited?

Cited by 78 publications

References 71 publications

Pathophysiology and treatment of osteoporosis: challenges for clinical practice in older people

Pathophysiology and treatment of osteoporosis: challenges for clinical practice in older people

Summary of Contact With Dr. Marik. Pulmonary Medicine and Critical Care. Eastern Virginia Medical School - Usa.

Impact of Natural Products on Developing New Treatments for Corona Virus Disease (COVID-19): Review

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