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The present work was carried out to study the impact of date palm pits as antibacterial activities on two species of pathogenic bacteria (klebsiella pneumonia and Escherichia coli) and its role in reducing side effect of methylprednisolone on the some neurotransmitter content in the brain, hormone testosterone and testclture of male albino rats .Date palm pits is most effective in inhibiting growth of bacteria as compared with antibiotics due to differences in resistance of bacteria to anti-tested materials due to change in membrane permeability of cells, thereby hindering the entry of enzymes or excreted by the change in the chemical composition of the constituent chemical. The results showed that the daily oral administration of pits of date palm caused the maximal increase in NE, DA& GABA content was found in the brain stem after 2 weeks. The daily oral administration of methylprednisolone caused decrease in NE,DA& GABA content was found in the brain stem after 2 weeks. Moreover, the daily oral administration of pits of date palm and methylprednisolone caused increase in NE content was found in the brain stem after 2 weeks. The daily oral administration of pits of date palm and methylprednisolone caused a significant increase in testosterone level in serum blood of male albino rat. From the present results, it is clear that Effect of chronic oral administration of methylprednisolone and pits of data palm on testicular of male albino rat caused recovery effect, notice high sperm in some tubules and tubular partial late spermatogenic arrest (spermatide level) is only seen in 10-20% of tubules. The appropriate recommendations in this study to use nuclei dates Antimicrobial on klebsiella pneumonia and Escherichia coli than the activity of standard antibiotics and the results concluded that using intended dates date palm pits as a preventive measure to reduce the side effects resulting from the use of a drug methylprednisolone on the some neurotransmitter content in the Brain. Hormone Testosterone and testclture in male albino rats.

Doxorubicin (Dox) induces senescence in numerous cancer cell types, but these senescent cancer cells relapse again if they are not eliminated. On this principle, we investigated the apoptotic effect of thymoquinone (TQ), the active ingredient of Nigella sativa seeds and costunolide (COS), the active ingredient of Costus speciosus, on the senescent colon (Sen-HCT116) and senescent breast (Sen-MCF7) cancer cell lines in reference to their corresponding proliferative cells to rapidly eliminate the senescent cancer cells. The senescence markers of Sen-HCT116 and Sen-MCF7 were determined by a significant decrease in bromodeoxyuridine (BrdU) incorporation and significant increases in SA-β-gal, p53, and p21 levels. Then proliferative, Sen-HCT116, and Sen-MCF7 cells were subjected to either TQ (50 µM) or COS (30 µM), the Bcl2-associated X protein (Bax), B-cell lymphoma 2 (Bcl2), caspase 3 mRNA expression and its activity were established. Results revealed that TQ significantly increased the Bax/Bcl2 ratio in HCT116 + Dox5 + TQ, MCF7 + TQ, and MCF7 + Dox5 + TQ compared with their corresponding controls. COS significantly increased the Bax/Bcl2 ratio in HCT116 + Dox5 + TQ and MCF7 + Dox5 + TQ compared with their related controls. Also, TQ and COS were significantly increased caspase 3 activity and cell proliferation of Sen-HCT116 and Sen-MCF7. The data revealed a higher sensitivity of senescent cells to TQ or COS than their corresponding proliferative cells.

Textile wastewater contains large quantities of azo dyes mixed with various contaminants especially heavy metal ions. The discharge of effluents containing methyl orange (MO) dye and Cu2+ ions into water is harmful because they have severe toxic effects to humans and the aquatic ecosystem. The dried algal biomass was used as a sustainable, cost-effective and eco-friendly for the treatment of the textile wastewater. Box–Behnken design (BBD) was used to identify the most significant factors for achieving maximum biosorption of Cu2+ and MO from aqueous solutions using marine alga Fucus vesiculosus biomass. The experimental results indicated that 3 g/L of F. vesiculosus biomass was capable of removing 92.76% of copper and 50.27% of MO simultaneously from aqueous solution using MO (60 mg/L), copper (200 mg/L) at pH 7 within 60 min with agitation at 200 rpm. The dry biomass was also investigated using SEM, EDS, and FTIR before and after MO and copper biosorption. FTIR, EDS and SEM analyses revealed obvious changes in the characteristics of the algal biomass as a result of the biosorption process. The dry biomass of F. vesiculosus can eliminate MO and copper ions from aquatic effluents in a feasible and efficient method.