Chemical and antimicrobial studies of monoterpene: Citral

Saddiq, Amna A.; Khayyat, Suzan A.

doi:10.1016/j.pestbp.2010.05.004

Cited by 142 publications

(85 citation statements)

References 11 publications

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“…In that study, the antimicrobial capacity of LMO was only matched by thyme oil. In the study by Saddiq and Khayyat (2010), concentrations of 50 ppm were able to inhibit growth of a methicillin resistant Staphylococcus aureus (MRSA) strain. For Helicobacter pylori, the study of Ohno et al (2003) with 13 essential oils demonstrated that lemongrass oil was the only able to inhibit growth even after 10 simultaneous passages, with a MIC of 4-18 ppm.…”

Section: Antimicrobial Activity Of Lmo Films Against Escherichia Colimentioning

confidence: 99%

Edible antimicrobial films based on microencapsulated lemongrass oil

Bustos

Matiacevich

2015

J Food Sci Technol

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Edible films and coatings have been proposed as viable alternatives for the preservation of fresh food such as fruit, meat, fish and cheese. They can be designed to contain natural antioxidants, vitamins and antimicrobials in order to extend shelf life of the product keeping the natural sensorial properties. Essential oils have been targeted as potential active principles for edible films and coatings given their wellrecognized antioxidant, antimicrobial and sensory properties. In the present work, lemongrass oil (LMO) microcapsules were prepared by the emulsification-separation method using sodium caseinate as wall material. Microcapsules had an average size of 22 μm and contained over 51 % oil in their nucleus. The release kinetics of the LMO components was studied for both, microcapsules and microcapsule containing films. Experimental data for the controlled release of LMO components showed good correlation with Peppas and Weibull models. The effect of the alginate matrix on the release parameters of the mathematical models could be detected by the modification of the b constant of the Weibull equation which changed from 0.167 for the microcapsules to 0.351 for the films. Films containing LMO at concentrations of 1250, 2500 and 5000 ppm were able to inhibit growth of Escherichia coli ATCC 25922 and Listeria monocytogenes ISP 65-08 in liquid cultures. A possible future application of these films for shelf life extension of fresh food is discussed.

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Section: Antimicrobial Activity Of Lmo Films Against Escherichia Colimentioning

confidence: 99%

Edible antimicrobial films based on microencapsulated lemongrass oil

Bustos

Matiacevich

2015

J Food Sci Technol

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“…Both linalool and decanal have demonstrated inhibition of S. aureus growth (Liu et al, 2012). Citral has been studied for its ability to inhibit a wide range of bacterial pathogens, such as S. aureus, as well as pathogenic fungi (Saddiq et al, 2010). As a result, these compounds are of interest as antibiotic alternatives.…”

Section: Introductionmentioning

confidence: 99%

Major components of orange oil inhibit Staphylococcus aureus growth and biofilm formation, and alter its virulence factors

Federman

Christopher

Biswas

2016

Journal of Medical Microbiology

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Bovine mastitis is a costly disease in the dairy industry and does not always respond to antibiotic treatment. The major components of terpeneless, cold-pressed Valencia orange oil -citral, linalool, decanal and valencene -were examined as potential alternative treatments for Staphylococcus aureus-associated mastitis. The minimum inhibitory concentration (MIC) of all four components against S. aureus was determined after incubation for 24 h. Growth inhibition assays were performed for all effective components on S. aureus for either a 3 h or 72 h treatment. These components were tested for the ability to disrupt pre-formed S. aureus biofilms after 24 h of treatment by measuring absorbance at 540 nm. Cytotoxicity against immortalized bovine mammary epithelial (MAC-T) cells was measured using an MTT assay following a 1 h exposure. Only concentrations below the 50 % cytostatic concentration (CC50) were used in an adherence and invasion assay of S. aureus on MAC-T cells, and for measurements of virulence and biofilm gene expression via qPCR. The MICs of citral and linalool were 0.02 % and 0.12 %, respectively, but decanal and valencene were ineffective. Citral and linalool were capable of inhibiting growth of S. aureus after 24 h at their MIC values and inhibited pre-formed biofilms of S. aureus. The concentrations below the CC50 were 0.02 % for citral and 0.12 % for linalool. These concentrations inhibited the adhesion and invasion ability of S. aureus and downregulated virulence genes. Only 0.12 % linalool downregulated the expression of S. aureus biofilm-forming genes. These components should be considered for further in vivo study.

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“…These properties are attributed primarily to the major constituent of the essential oil, the citral, which is a natural combination of two isomeric aldehydes (Figure 1), neral (cis-citral) and geranial (trans-citral). Together these compounds represent approximately 65-85% of the essential oil (SADDIQ & KHAYYAT, 2010).…”

Section: Introductionmentioning

confidence: 99%

Anthelmintic activity of Cymbopogon citratus against Haemonchus contortus

Macedo

Oliveira

Ribeiro

et al. 2015

Rev. Bras. Parasitol. Vet.

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Parasitic nematodes are of major economic importance in livestock. An alternative for the control of parasites is phytotherapy. This study evaluated the efficacy of Cymbopogon citratus decoction (CcD), C. citratus essential oil (CcEo) and citral against Haemonchus contortus using in vitro egg hatch test (EHT) and larval development test (LDT) and an in vivo test using a Meriones unguiculatus (gerbil) model. The effect of 800 mg/kg CcEo was evaluated in gerbils that had been artificially infected with 5,000 third-stage H. contortus larvae. The effective concentrations required to inhibit 50% (EC50) of egg hatching were 0.46, 0.14 and 0.13 mg/mL for CcD, CcEo and citral, respectively. The EC50 values in the LDT were 5.04, 1.92 and 1.37 mg/mL for CcD, CcEo and citral, respectively. H. contortus population in the group treated with C. citratus essential oil was reduced by 38.5% (P< 0.05) in comparison to the control group. These results suggest that it may be possible to use C. citratus essential oil to control of H. contortus parasite of small ruminant.Keywords: Phytotherapy, anthelmintic, Meriones unguiculatus, in vitro, citral. ResumoO parasitismo por nematoides tem grande importância econômica no rebanho. Uma alternativa para o controle de parasitas é a fitoterapia. Este estudo avaliou a eficácia do decocto de Cymbopogon citratus (DCc), do óleo essencial de C. citratus (OECc) e do citral contra Haemonchus contortus utilizando o teste in vitro de eclosão dos ovos (TEO) e o teste de desenvolvimento larval (TDL) e um teste in vivo com modelo Meriones unguiculatus (gerbil). O efeito de 800 mg/kg de OECc foi avaliado em gerbils infectados artificialmente com 5000 larvas de terceira fase de H. contortus. As concentrações efetivas necessárias para inibir 50% (CE50) da eclosão dos ovos foram 0,46; 0,14 e 0,13 mg/mL para DCc, OECc e citral, respectivamente. Os valores da CE50 no TDL foram de 5,04; 1,92 e 1,37 mg/mL para DCc, OECc e citral, respectivamente. No grupo tratado com óleo de C. citratus a população H. contortus foi reduzida em 38,5% (P < 0,05) em comparação com o grupo controle. Estes resultados sugerem que pode ser possível a utilização de óleo essencial de C. citratus para controle de H. contortus, parasita de pequenos ruminantes.Palavras-chave: Fitoterapia, anti-helmínticos, Meriones unguiculatus, in vitro, citral.

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Chemical and antimicrobial studies of monoterpene: Citral

Cited by 142 publications

References 11 publications

Edible antimicrobial films based on microencapsulated lemongrass oil

Edible antimicrobial films based on microencapsulated lemongrass oil

Major components of orange oil inhibit Staphylococcus aureus growth and biofilm formation, and alter its virulence factors

Anthelmintic activity of Cymbopogon citratus against Haemonchus contortus

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