Vitamin D, the natural way

Aguilar-Shea, Antonio L.

doi:10.1016/j.clnesp.2020.12.001

Cited by 25 publications

(15 citation statements)

References 8 publications

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“…91 In this sense, some preventive strategies for adequate vitamin D levels include fish consumption, food fortification, 92 and advice on moderate sunlight exposure. 1 93…”

Section: Discussionmentioning

confidence: 99%

“…91 In this sense, some preventive strategies for adequate vitamin D levels include fish consumption, food fortification, 92 and advice on moderate sunlight exposure. 1,93 Among the few countries with specific policies, the United Kingdom and Finland stand out with the recommendation of 10 μg of vitamin D daily intake for general population, and the mandatory food fortification programs, respectively. 94 In pregnant women, conflicting evidence suggests the benefit of supplementation, despite the documented negative clinical, humanistic, and economic impact of the deficiency or insufficiency of vitamin D, mainly, during the first trimester of pregnancy.…”

Section: Discussionmentioning

confidence: 99%

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Deficiency and Insufficiency of Vitamin D in Women of Childbearing Age: A Systematic Review and Meta-analysis

Lucchetta

Lemos

Gini

et al. 2022

Rev Bras Ginecol Obstet

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Objective To estimate the prevalence of inadequate vitamin D level and its associated factors for women of childbearing age in Brazil. Methods A systematic review was conducted (last updated May 2020). Meta-analyses were performed using the inverse-variance for fixed models with summary proportion calculation by Freeman-Tukey double arcsine. Reporting and methodological quality were assessed using the Joanna Briggs Institute tool for prevalence studies. Results Our review identified 31 studies, comprising 4,006 participants. All the studies had at least one weakness, mainly due to the use of convenience sampling and small sample size. The overall prevalence of vitamin D deficiency, insufficiency, and both deficiency and insufficiency were 35% (confidence interval, 95%CI: 34–37%), 42% (95%CI: 41–44%), and 72% (95%CI: 71–74%), respectively. Conclusion Although the magnitude of the prevalence of inadequate levels of vitamin D is uncertain, the evidence suggests that presence of vitamin D deficiency or insufficiency in women of reproductive age can cause moderate to severe problems.

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“…91 In this sense, some preventive strategies for adequate vitamin D levels include fish consumption, food fortification, 92 and advice on moderate sunlight exposure. 1 93…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Deficiency and Insufficiency of Vitamin D in Women of Childbearing Age: A Systematic Review and Meta-analysis

Lucchetta

Lemos

Gini

et al. 2022

Rev Bras Ginecol Obstet

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show abstract

“…However, in the last decade, various other functions of vitamin D have been reported. Vitamin D is measured in the body by determining the levels of 25-hydroxycholecalciferol (25[OH]D) and values below 20 ng/mL (50 nmol/L) are considered inadequate [ 57 ]. The optimal serum concentration of 25(OH)D must exceed 30 ng/mL.…”

Section: Vitamin D Deficiency and Osteoporosismentioning

confidence: 99%

Recognized and Emerging Features of Erythropoietic and X-Linked Protoporphyria

et al. 2022

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Erythropoietic protoporphyria (EPP) and X-linked protoporphyria (XLP) are inherited disorders resulting from defects in two different enzymes of the heme biosynthetic pathway, i.e., ferrochelatase (FECH) and delta-aminolevulinic acid synthase-2 (ALAS2), respectively. The ubiquitous FECH catalyzes the insertion of iron into the protoporphyrin ring to generate the final product, heme. After hemoglobinization, FECH can utilize other metals like zinc to bind the remainder of the protoporphyrin molecules, leading to the formation of zinc protoporphyrin. Therefore, FECH deficiency in EPP limits the formation of both heme and zinc protoporphyrin molecules. The erythroid-specific ALAS2 catalyses the synthesis of delta-aminolevulinic acid (ALA), from the union of glycine and succinyl-coenzyme A, in the first step of the pathway in the erythron. In XLP, ALAS2 activity increases, resulting in the amplified formation of ALA, and iron becomes the rate-limiting factor for heme synthesis in the erythroid tissue. Both EPP and XLP lead to the systemic accumulation of protoporphyrin IX (PPIX) in blood, erythrocytes, and tissues causing the major symptom of cutaneous photosensitivity and several other less recognized signs that need to be considered. Although significant advances have been made in our understanding of EPP and XLP in recent years, a complete understanding of the factors governing the variability in clinical expression and the severity (progression) of the disease remains elusive. The present review provides an overview of both well-established facts and the latest findings regarding these rare diseases.

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“…Vitamin D is an essential dietary nutrient known for its critical function in bone homeostasis. It is also involved in absorption of inorganic elements (such as calcium, phosphorus, and magnesium), kidney dysfunction (by reducing proteinuria and inflammation) and immune responses ( 39 – 42 ). There are two forms of vitamin D, ergocalciferol (vitamin D2), and cholecalciferol (vitamin D3).…”

Section: Micronutrientsmentioning

confidence: 99%

Host and Clostridioides difficile-Response Modulated by Micronutrients and Glutamine: An Overview

et al. 2022

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Changes in intestinal microbiota are integral to development of Clostridioides difficile (C. difficile)—associated nosocomial diarrhea. Certain diets, especially Western diets, increase susceptibility to C. difficile infection (CDI). Here, we discuss recent findings regarding how nutrients modulate response of the host and C. difficile during infection. Calcium has a role in the sporulation and germination process. Selenium is effective in reducing the total amount of C. difficile toxin A (TcdA) and toxin B (TcdB) and in decreasing its cytotoxicity. In addition, selenium phosphate synthetase deficiency reduces C. difficile growth and spore production. On the other hand, iron has a dual role in C. difficile growth. For instance, high intracellular levels can generate reactive hydroxyl radicals, whereas low levels can reduce its growth. In humans, zinc deficiency appears to be related to the recurrence of CDI, in contrast, in the CDI model in mice a diet rich in zinc increased the toxin's activity. Low vitamin D levels contribute to C. difficile colonization, toxin production, and inflammation. Furthermore, glutamine appears to protect intestinal epithelial cells from the deleterious effects of TcdA and TcdB. In conclusion, nutrients play an important role in modulating host and pathogen response. However, further studies are needed to better understand the mechanisms and address some controversies.

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Vitamin D, the natural way

Cited by 25 publications

References 8 publications

Deficiency and Insufficiency of Vitamin D in Women of Childbearing Age: A Systematic Review and Meta-analysis

Deficiency and Insufficiency of Vitamin D in Women of Childbearing Age: A Systematic Review and Meta-analysis

Recognized and Emerging Features of Erythropoietic and X-Linked Protoporphyria

Host and Clostridioides difficile-Response Modulated by Micronutrients and Glutamine: An Overview

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