Vitamin D, Vascular Calcification and Mortality among Alcoholics

Quintero-Platt, Geraldine; González‐Reimers, Emilio; Martín-González, M. Candelaria; Jorge-Ripper, Carlos; Hernández-Luis, Rubén; Abreu-González, Pedro; Rodrı́guez-Gaspar, Melchor; Santolaria-Fernández, Francisco

doi:10.1093/alcalc/agu076

Cited by 14 publications

(16 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, in our study, significantly increased cortical porosity was observed only in mice receiving ethanol which corresponds with a lower levels of ALP, GSH and Ca in the E group. Generally, liver dysfunction is associated with vitamin D deficiency [31]. Ethanolʼs toxic skeletal effects have been suggested to involve impaired vitamin D/calcium homeostasis [32].…”

Section: Discussionmentioning

confidence: 99%

Single and simultaneous effects of acrylamide and ethanol on bone microstructure of mice after one remodeling cycle

Sarocka

Kováčová

Omelka

et al. 2019

BMC Pharmacol Toxicol

View full text Add to dashboard Cite

Background This study aimed to examine femoral bone microstructure of mice after single and simultaneous administration to acrylamide and ethanol since both substances are often consumed separately and/or together by humans. Interactive effects of these toxins were analysed after one remodeling cycle. Methods Twenty clinically healthy adult mice were randomly divided into four groups following 2 weeks administration of toxins: A group - mice were fed with acrylamide (40 mg/kg bw); E group - mice were ethanol-fed (15% ethanol); AE group - mice were simultaneously fed with both toxins, and a C group – control (without acrylamide and/or ethanol supplementation). Generally, 2D and 3D imaging methods were used to determine cortical and trabecular bone tissues microstructure. Biochemical analyses of plasma parameters were also realized using commercially available ELISA tests and spectrophotometrically. Results Single and simultaneous exposure to acrylamide and ethanol affected only cortical bone microstructure. No significant changes in trabecular bone morphometry were detected among all groups. In mice from the A group, increased endocortical remodeling associated with a higher level of serum calcium and vasoconstriction of primary osteon’s vascular canals (POVC) were identified. On the contrary, increased cortical porosity consistent with a decreased relative bone volume, bone mineral density (BMD) and lower levels of alkaline phosphatase (ALP), glutathione (GSH), calcium in plasma and also with vasodilation of POVC were observed in the E group. In the AE group, the highest density of secondary osteons associated with a lower BMD and decreased levels of ALP, GSH were documented. The parameters of POVC and Haversian canals approximated to the C group. In addition, single and simultaneous exposure to both toxins caused liver disease consistent with a higher values of alanine aminotransferase (ALT), aspartate aminotransferase (AST) in plasma of all experimental groups. Conclusions Single administration to acrylamide and ethanol had negative effects on cortical bone structure of mice after one remodeling cycle. However, we identified possible antagonistic impact of these toxins on the structure of the cortical bone.

show abstract

Section: Discussionmentioning

confidence: 99%

Single and simultaneous effects of acrylamide and ethanol on bone microstructure of mice after one remodeling cycle

Sarocka

Kováčová

Omelka

et al. 2019

BMC Pharmacol Toxicol

View full text Add to dashboard Cite

show abstract

“…Substance use disorders increase the long term risk of serious health complications (Hossain et al, 2007;Nazrul Islam et al, 2001;Quintero-Platt et al, 2015) and are linked to increased mortality (Quintero-Platt et al, 2015). Liver disease, cirrhosis, cardiovascular disease (Quintero-Platt et al, 2015;Zhang et al, 2008), diabetes, pulmonary disease (Zhang et al, 2008), poor wound healing (Guo and Dipietro, 2010), lowered immune function (Housova et al, 2005;Quintero-Platt et al, 2015) and depression (Tolliver and Anton, 2015) have all been linked to substance use disorders, as have the spread of HIV and hepatitis through illegal drug use (Nabipour et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

The importance of nutrition in aiding recovery from substance use disorders: A review

Jeynes

Gibson

2017

Drug and Alcohol Dependence

101

View full text Add to dashboard Cite

show abstract

“…Consequently, less calcium will be absorbed when there is a lack of vitamin D. Heavy vitamin D nutrient deficiencies result in bone deformation, known as rickets (for an overview: [41]). Chronic alcohol consumption is associated with low vitamin D concentrations in the blood and a cause of low calcium admission responsible for bone changes [14,[42][43][44]. Moreover, vitamin D deficiency is common among alcoholic patients and results a higher long-term mortality [44].…”

Section: Discussionmentioning

confidence: 99%

“…Chronic alcohol consumption is associated with low vitamin D concentrations in the blood and a cause of low calcium admission responsible for bone changes [14,[42][43][44]. Moreover, vitamin D deficiency is common among alcoholic patients and results a higher long-term mortality [44].…”

Section: Discussionmentioning

confidence: 99%

Calcium Carbonate Attenuates Withdrawal and Reduces Craving: A Randomized Controlled Trial in Alcohol-Dependent Patients

et al. 2021

View full text Add to dashboard Cite

Introduction: Preclinical studies have shown that calcium seems to be the active component of the anti-craving drug acamprosate (Ca2+ bis-acetyl-homotaurinate). Clinical effects in humans have also indicated an association between increased calcium plasma concentration due to acamprosate treatment and better outcome relating to time to relapse and cumulative abstinence. In contrast, low calcium concentration in alcohol-dependent patients was related with craving for alcohol. The main goal of the trial was to investigate whether an oral calcium administration is able to affect craving, withdrawal, and relapse risk in alcohol-dependent patients. Methods: We conducted a single-blind, randomized, monocentric, controlled clinical two-arm trial in alcohol-dependent patients (Clinical Trials Registration: DRKS00011293). A total of 55 alcohol-dependent subjects received calcium carbonate (800 mg + 5 μg vitamin D) versus sodium bicarbonate (1,000 mg) daily during the 14 days of inpatient alcohol-withdrawal treatment. Results: Based on an intention-to-treat protocol, withdrawal intensity (assessed with CIWA-Ar) in the calcium carbonate group attenuated faster than in the sodium bicarbonate subgroup. Alcohol craving (assessed with OCDS) in the calcium carbonate subgroup was also significantly reduced versus the sodium bicarbonate subgroup. Conclusion: Our data support earlier findings and show that treatment with calcium carbonate during alcohol withdrawal reduces symptoms of alcohol withdrawal as well as alcohol craving in a controlled clinical pilot study. Mode of actions will need to be determined to allow the further development of pharmacological interventions beyond Ca2+ bis-acetyl-homotaurinate.

show abstract

Vitamin D, Vascular Calcification and Mortality among Alcoholics

Abstract: Vitamin D deficiency is common among alcoholic patients and is associated with low lean mass and liver dysfunction. Among non-cirrhotics, serum vitamin D levels below 30 ng/ml are associated with a greater long-term mortality.

Cited by 14 publications

References 36 publications

Single and simultaneous effects of acrylamide and ethanol on bone microstructure of mice after one remodeling cycle

Single and simultaneous effects of acrylamide and ethanol on bone microstructure of mice after one remodeling cycle

The importance of nutrition in aiding recovery from substance use disorders: A review

Calcium Carbonate Attenuates Withdrawal and Reduces Craving: A Randomized Controlled Trial in Alcohol-Dependent Patients

Contact Info

Product

Resources

About