Vitamin D (VD3) antioxidative and anti-inflammatory activities: Peripheral and central effects

Leal, Luzia Kalyne Almeida Moreira; Lima, Ludmila Araújo Rodrigues; Aquino, Pedro Éverson Alexandre de; Sousa, João Antônio Costa de; Gadelha, Carlos Vinicius Jataí; Calou, Iana Bantim Felício; Lopes, Maria Janice Pereira; Lima, Francisco Kleber A.; Neves, Kelly Rose Tavares; Andrade, Geanne Matos de; Viana, Glauce Socorro de Barros

doi:10.1016/j.ejphar.2020.173099

Cited by 53 publications

(23 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The active hormone derived from vitamin D is 1,25(OH) 2 D3, which mediates numerous biological processes. The active vitamin D is associated with many other cellular functions like anti‐inflammatory and antioxidant properties to support physiological function and activity 15‐17 . It can be used to treat rickets, osteoporosis, hypothyroidism, psoriasis, and diseases caused by a lack of calcium or vitamin D. Vitamin D has also been reported to prevent the development of cancers.…”

Section: Introductionmentioning

confidence: 99%

“…The active vitamin D is associated with many other cellular functions like anti‐inflammatory and antioxidant properties to support physiological function and activity. 15 , 16 , 17 It can be used to treat rickets, osteoporosis, hypothyroidism, psoriasis, and diseases caused by a lack of calcium or vitamin D. Vitamin D has also been reported to prevent the development of cancers. The deficiency of active vitamin D is related to the incidence of complications in T2DM patients.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of vitamin D on oxidative stress and serum inflammatory factors in the patients with type 2 diabetes

WeiGang

et al. 2022

Clinical Laboratory Analysis

View full text Add to dashboard Cite

The type 2 diabetes mellitus (T2DM) is an urgent global health problem. T2DM patients are in a state of high oxidative stress and inflammation. Vitamin D and glutathione (GSH) play crucial roles in antioxidation and anti‐inflammation. However, T2DM patients have lower vitamin D and GSH levels than healthy persons. A randomized controlled trial was conducted to see the effect of the vitamin D supplementation on oxidative stress and inflammatory factors in T2DM patients. In this study, a total of 178 T2DM patients were randomly enrolled, 92 patients received regular treatment (T2DM group) and 86 patients in Vitamin D group received extra vitamin D 400 IU per day in addition to regular treatment. Serum vitamin D, GSH, GSH metabolic enzyme GCLC and GR, inflammatory factor MCP‐1, and IL‐8 levels were investigated. We found that the T2DM group has significantly higher concentrations of MCP‐1 and IL‐8 than those in the healthy donor group. After vitamin D supplementation for 90 days, T2DM patients had a 2‐fold increase of GSH levels, from 2.72 ± 0.84 to 5.76 ± 3.19 μmol/ml, the concentration of MCP‐1 decreased from 51.11 ± 20.86 to 25.42 ± 13.06 pg/ml, and IL‐8 also decreased from 38.21 ± 21.76 to 16.05 ± 8.99 pg/ml. In conclusion, our study demonstrated that vitamin D could regulate the production of GSH, thereby reducing the serum levels of MCP‐1 and IL‐8, alleviating oxidative stress and inflammation, providing evidence of the necessity and feasibility of adjuvant vitamin D treatment among patients with T2DM. On the other hand, vitamin D and GSH levels have important diagnostic and prognostic values in T2DM patients.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of vitamin D on oxidative stress and serum inflammatory factors in the patients with type 2 diabetes

WeiGang

et al. 2022

Clinical Laboratory Analysis

View full text Add to dashboard Cite

show abstract

“…Vitamin D is indicated to suppress cytokine cascade, resulting in reduced mortality in SARS-CoV-2 (Daneshkhah et al., 2020 ) and has been shown in mouse models to have anti-inflammatory and anti-oxidant effects both peripherally and centrally (Almeida Moreira Leal et al., 2020 ). Interest in vitamin D research is reflected in nine articles in April and May of 2020 retrieved on PubMed (Sayers et al., 2020 ).…”

Section: Evaluation Of the Hypothesismentioning

confidence: 99%

“…Taken together, the latitude hypothesis and the statistically concomitant vitamin D deficit in the populations at greatest risk for SARS-CoV-2 mortality (Calgary, 2020) (elderly, non-white persons), and the action of vitamin D on immunity (Almeida Moreira Leal et al, 2020;Daneshkhah et al, 2020) suggest that vitamin D supplementation (400-4000 IU pod) is a safe intervention with great potential to reduce morbidity during flu season and in current COVID-9 pandemic.…”

Section: Consequences and Possible Interventionmentioning

confidence: 99%

The latitude hypothesis, vitamin D, and SARS-Co-V2

Hedlund¹,

Diamond²,

Uversky

2020

Journal of Biomolecular Structure and Dynamics

View full text Add to dashboard Cite

show abstract

“…VDR is expressed in most human cells, supporting the hypothesis that vitamin D 3 has a pleiotropic effect. Moreover, anti-inflammatory and antiangiogenic effects of vitamin D 3 have been widely elucidated both in in vitro and in vivo studies (Majewski et al, 1996;Albert et al, 2007;Maj et al, 2018;Almeida Moreira Leal et al, 2020). Interestingly, the vitamin D 3 receptor is expressed in the RPE layer, which along with enzymes is able to convert the inactive form into the active form.…”

Section: Introductionmentioning

confidence: 99%

Effects of Vitamin D3 and Meso-Zeaxanthin on Human Retinal Pigmented Epithelial Cells in Three Integrated in vitro Paradigms of Age-Related Macular Degeneration

et al. 2021

View full text Add to dashboard Cite

Age-related macular degeneration (AMD) is a degenerative retinal disease and one of major causes of irreversible vision loss. AMD has been linked to several pathological factors, such as oxidative stress and inflammation. Moreover, Aβ (1–42) oligomers have been found in drusen, the extracellular deposits that accumulate beneath the retinal pigmented epithelium in AMD patients. Hereby, we investigated the hypothesis that treatment with 1,25(OH) 2D3 (vitamin D3) and meso-zeaxathin, physiologically present in the eye, would counteract the toxic effects of three different insults on immortalized human retinal pigmented epithelial cells (ARPE-19). Specifically, ARPE-19 cells have been challenged with Aβ (1–42) oligomers, H2O2, LPS, and TNF-α, respectively. In the present study, we demonstrated that the combination of 1,25(OH)2D3 and meso-zeaxanthin significantly counteracted the cell damage induced by the three insults, at least in these in vitro integrated paradigms of AMD. These results suggest that combination of 1,25(OH)2D3 and meso-zeaxathin could be a useful approach to contrast pathological features of AMD, such as retinal inflammation and oxidative stress.

show abstract

Vitamin D (VD3) antioxidative and anti-inflammatory activities: Peripheral and central effects

Cited by 53 publications

References 37 publications

Effect of vitamin D on oxidative stress and serum inflammatory factors in the patients with type 2 diabetes

Effect of vitamin D on oxidative stress and serum inflammatory factors in the patients with type 2 diabetes

The latitude hypothesis, vitamin D, and SARS-Co-V2

Effects of Vitamin D3 and Meso-Zeaxanthin on Human Retinal Pigmented Epithelial Cells in Three Integrated in vitro Paradigms of Age-Related Macular Degeneration

Contact Info

Product

Resources

About