Vitamin D: What's new a year on from the COVID‐19 outbreak?

Gibson‐Moore, H.

doi:10.1111/nbu.12499

Cited by 9 publications

(13 citation statements)

References 37 publications

(59 reference statements)

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“…Since the onset of the COVID-19 infection outbreak, various research has been published, and there have been more meta-analyses and systematic reviews on the available evidence on the course of the disease and its related risk factors, but all previous researches have concluded that there is still a lack of strong evidence to support the direct role of Vit D and the severity or outcomes of COVID‐19 infection. 49 …”

Section: Discussionmentioning

confidence: 99%

The Impact of Vitamin D Level on the Severity and Outcome of Hospitalized Patients with COVID-19 Disease

Alkhafaji¹,

Argan²,

Albaker³

et al. 2022

IJGM

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Purpose The world is experiencing a life-altering and extraordinary situation in response to the COVID-19 pandemic. There are limited data and controversies regarding the relationship between vitamin D (Vit D) status and COVID-19 disease. Thus, this study was designed to investigate the association between Vit D levels and the severity or outcomes of COVID-19 disease. Methods A cross-sectional observational study was conducted in the Eastern province of Saudi Arabia from January to August 2021. All the admitted patients who were diagnosed with COVID-19 infection were distributed into three groups depending on their Vit D levels: normal, insufficiency, and deficiency. For the three groups, demographic data, and laboratory investigations as well as data regarding the severity of COVID-19 were collected and analysed. Results A total of 203 diagnosed cases of COVID-19 were included in this study. The Vit D level was normal (>30) in 31 (15.3%) cases, insufficient in 45 (22.2%) cases and deficient in 127 (62.6%) cases. Among the included cases, 58 (28.6%) were critical cases, 109 (53.7%) were severe and 36 (17.7%) had a mild-moderate COVID-19 infection. The most prevalent comorbidity of patients was diabetes mellitus 117 (57.6%), followed by hypertension 70 (34.5%), cardiac disease 24 (11.8%), chronic kidney disease 19 (9.4%) and chronic respiratory disease in 17 (8.4%) cases. Importantly, the current study did not detect any significant association between Vit D status and COVID-19 severity (p-value=0.371) or outcomes (hospital stay, intensive care units admission, ventilation, and mortality rate) (p-value > 0.05), even after adjusting the statistical model for the confounders. Conclusion In hospital settings, Vit D levels are not associated with the severity or outcomes of COVID-19 disease. Further, well‐designed studies are required to determine whether Vit D status provides protective effects against worse COVID-19 outcomes.

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Section: Discussionmentioning

confidence: 99%

The Impact of Vitamin D Level on the Severity and Outcome of Hospitalized Patients with COVID-19 Disease

Alkhafaji¹,

Argan²,

Albaker³

et al. 2022

IJGM

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“…A century later, vitamin D continues to be a specific hot topic as evidenced by the number of papers published in recent years in Nutrition Bulletin (Allen et al, 2014; Buttriss & Lanham‐New, 2020; Clark et al, 2021; Gibson‐Moore, 2021; Guo et al, 2019; Hengist et al, 2019; Lanham‐New et al, 2022; Mendes et al, 2018; Smith & Hart, 2017; Spiro & Buttriss, 2014; Tripkovic, 2013; Tripkovic et al, 2017; Wilson‐Barnes et al, 2020). These papers have been brought together in a specially curated Virtual Issue [https://onlinelibrary.wiley.com/doi/toc/10.1111/(ISSN)1467-3010.Vitamin-D-Centenary].…”

Section: Figurementioning

confidence: 99%

Vitamin D: One hundred years on

Buttriss¹,

Lanham-New

2022

Nutrition Bulletin

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“…Vitamin D (Vit D) is an oxysterol hormone with important immunomodulatory and antiviral properties [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 ]. Even though this vitamin is often recommended as a nutritional supplement in treatment guidelines and prescribed for the management of coronavirus disease 2019 (COVID-19) [ 9 , 10 , 11 , 12 ], several studies have yielded divergent or inconclusive results [ 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 ].…”

Section: Introductionmentioning

confidence: 99%

The Interaction of Vitamin D and Corticosteroids: A Mortality Analysis of 26,508 Veterans Who Tested Positive for SARS-CoV-2

Efird

Anderson

Jindal

et al. 2021

IJERPH

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This data-based cohort consisted of 26,508 (7%) United States veterans out of the 399,290 who tested positive for SARS-CoV-2 from 1 March to 10 September 2020. We aimed to assess the interaction of post-index vitamin D (Vit D) and corticosteroid (CRT) use on 30-day mortality among hospitalized and non-hospitalized patients with coronavirus disease 2019 (COVID-19). Combination Vit D and CRT drug use was assessed according to four multinomial pairs (−|+, −|−, +|+, +|−). Respective categorical effects were computed on a log-binomial scale as adjusted relative risk (aRR). Approximately 6% of veterans who tested positive for SARS-CoV-2 died within 30 days of their index date. Among hospitalized patients, a significantly decreased aRR was observed for the use of Vit D in the absence of CRTs relative to patients who received CRTs but not Vit D (aRR = 0.30; multiplicity corrected, p = 0.0004). Among patients receiving systemically administered CRTs (e.g., dexamethasone), the use of Vit D was associated with fewer deaths in hospitalized patients (aRR = 0.51) compared with non-hospitalized patients (aRR = 2.5) (P-for-Interaction = 0.0071). Evaluating the effect of modification of these compounds in the context of hospitalization may aid in the management of COVID-19 and provide a better understanding of the pathophysiological mechanisms underlying this and future infectious disease outbreaks.

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Vitamin D: What's new a year on from the COVID‐19 outbreak?

Cited by 9 publications

References 37 publications

The Impact of Vitamin D Level on the Severity and Outcome of Hospitalized Patients with COVID-19 Disease

The Impact of Vitamin D Level on the Severity and Outcome of Hospitalized Patients with COVID-19 Disease

Vitamin D: One hundred years on

The Interaction of Vitamin D and Corticosteroids: A Mortality Analysis of 26,508 Veterans Who Tested Positive for SARS-CoV-2

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