Vitamin D2 modulates melittinâmembrane interactions

Severcan, Feride; Durmus, Huseyin Okan; Eker, Fatma; Akinoglu, Bülent G.; Haris, Parvez I.

doi:10.1016/s0039-9140(00)00453-7

Cited by 18 publications

(20 citation statements)

References 38 publications

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“…The turbidity technique at visible range is a spectroscopic technique that provides valuable information about membrane phase transition temperatures and membrane order [42,43]. Lipid turbidity study has been previously utilised in membrane research [42,44,45].…”

Section: Resultsmentioning

confidence: 99%

Effect of chitosan coating on the characteristics of DPPC liposomes

Mady

Darwish

2010

Journal of Advanced Research

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Because it is both biocompatible and biodegradable, chitosan has been used to provide a protective capsule in new drug formulations. The present work reports on investigations into some of the physicochemical properties of chitosan-coated liposomes, including drug release rate, transmission electron microscopy (TEM), zeta potential and turbidity measurement. It was found that chitosan increases liposome stability during drug release. The coating of DPPC liposomes with a chitosan layer was confirmed by electron microscopy and the zeta potential of liposomes. The coating of liposomes by chitosan resulted in a marginal increase in the size of the liposomes, adding a layer of (92 ± 27.1 nm). The liposomal zeta potential was found to be increasingly positive as chitosan concentration increased from 0.1% to 0.3% (w/v), before stabilising at a relatively constant value. Turbidity studies revealed that the coating of DPPC liposomes with chitosan did not significantly modify the main phase transition temperature of DPPC at examined chitosan concentrations. The appropriate combination of liposomal and chitosan characteristics may produce liposomes with specific, prolonged and controlled release.

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Section: Resultsmentioning

confidence: 99%

Effect of chitosan coating on the characteristics of DPPC liposomes

Mady

Darwish

2010

Journal of Advanced Research

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“…The frequency of these bands give information about the order/disorder state of the membrane depending on the average trans/gauche isomerization in the system, and shifts to higher wavenumbers correspond to an increase in the number of gauche conformers which implies a more disordered state [5,23]. Figure 1 displays the average frequency changes in the CH 2 antisymmetric stretching mode of DSPC:Chol MLVs (mol ratio of 3:1), in the presence and absence of 6 and 18 mol% CLX at 30 and 65 • C. These CLX concentrations were chosen according to our previous findings which indicated that 6 and 18 mol% CLX show opposing effects on DSPC model membranes [22].…”

Section: Resultsmentioning

confidence: 99%

Effects of the non-steroidal anti-inflammatory drug celecoxib on cholesterol containing distearoyl phosphatidylcholine membranes

2011

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Abstract.The effects of different concentrations of celecoxib on the acyl chain order, dynamics and the hydration status of the head group and interfacial region of model membranes containing DSPC and cholesterol were investigated in detail using Fourier transform infrared spectroscopy. Our results reveal that regardless of the presence of cholesterol, celecoxib is able to alter the physical properties of membranes. It exerts opposing effects on membrane order at high and low concentrations and decreases membrane fluidity in the presence of cholesterol. An evidence of phase separation has also been observed. The decrease in membrane fluidity supports the hypothesis that celecoxib may induce changes in the activity of membrane bound enzymes through modulating physical properties of the membrane thereby contributing to its anticancer activity. A possible change in the location of celecoxib in DSPC membranes when cholesterol is present has also been proposed. These results clarify, to a certain extent, the molecular interactions of celecoxib with membrane systems and may additionally contribute to a better understanding of COX-2 independent mechanisms of celecoxib action.

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“…The bandwidth jumps near the main phase transition. These modifications are analyzed in the literature [7,[11][12][13][14][15][16] for various types of phospholipids. We give a physical explanation of these modifications by analyzing the bandwidth values at different temperatures and different GS concentrations relevant for the dynamics of the chemical bonds implied in the IR bands' appearance.…”

Section: Resultsmentioning

confidence: 99%

“…Multilamellar DPPG liposomes were obtained [11,14,15] by vortexing DPPG thin films in excess Na 2 HPO 4 buffer for 20 min at 66 C. The liposomes were incubated in a shaking water bath for 1 h at a temperature around 45 C. The DPPG=GS systems were obtained from a stock solution of GS in ethanol. Multilamellar GS-containing vesicles were obtained using the same procedure followed for the DPPG vesicle preparation proposed in Refs.…”

Section: Methodsmentioning

confidence: 99%

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Effect of Gramicidin S on the Dipalmitoylphosphatidyl-glycerol Thermotropic Phase Transition in DPPG/GS Systems: A Mathematical Approach

Stan

Cristescu

Severcan

et al. 2006

Molecular Crystals and Liquid Crystals

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We present a mathematical approach to the experimental data recorded via Fourier transform-infrared spectroscopy regarding the influence of the concentration of the antimicrobial peptide gramicidin S (GS) on the thermotropic phase transition of the dipalmitoylphosphatidyl-glycerol (DPPG) lipid bilayer membrane in DPPG=GS systems. The model is based on the influence of the GS concentration on the parameters of a nonlinear damped oscillator, which models the CH 2 symmetric stretching band.

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Vitamin D2 modulates melittinâmembrane interactions

Cited by 18 publications

References 38 publications

Effect of chitosan coating on the characteristics of DPPC liposomes

Effect of chitosan coating on the characteristics of DPPC liposomes

Effects of the non-steroidal anti-inflammatory drug celecoxib on cholesterol containing distearoyl phosphatidylcholine membranes

Effect of Gramicidin S on the Dipalmitoylphosphatidyl-glycerol Thermotropic Phase Transition in DPPG/GS Systems: A Mathematical Approach

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Vitamin D2 modulates melittinâmembrane interactions

Cited by 18 publications

References 38 publications

Effect of chitosan coating on the characteristics of DPPC liposomes

Effect of chitosan coating on the characteristics of DPPC liposomes

Effects of the non-steroidal anti-inflammatory drug celecoxib on cholesterol containing distearoyl phosphatidylcholine membranes

Effect of Gramicidin S on the Dipalmitoylphosphatidyl-glycerol Thermotropic Phase Transition in DPPG/GS Systems: A Mathematical Approach

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Product

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Vitamin D2 modulates melittinâmembrane interactions