Vitamin D3 attenuates cortical infarction induced by middle cerebral arterial ligation in rats

Wang, Y; Chiang, Yung Hsiao; Tp, Su; Hayashi, Teruo; Morales, Marisela; Hoffer, Barry J.; Lin, Shinn Zong

doi:10.1016/s0028-3908(99)00255-5

Cited by 183 publications

(168 citation statements)

References 38 publications

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“…These observations suggest that the effect of 1,25-dihydroxyvitamin D 3 on GDNF expression might be cell type dependent. There are also evidences that 1,25-dihydroxyvitamin D 3 increases GDNF levels in vivo (Wang et al, 2000;Sanchez et al, 2002). This neurotrophic effect might contribute to the finding that pretreatment with 1,25-dihydroxyvitamin D 3 protects against 6-OHDA-mediated depletion of dopamine and its metabolites in the substantia nigra, while in vitro it protects primary mesencephalic neurons against 6-OHDA-or H 2 O 2 -induced cell death (Wang et al, 2001b).…”

Section: Vitamin Dmentioning

confidence: 96%

Driving GDNF expression: The green and the red traffic lights

Saavedra

Baltazar

Duarte

2008

Progress in Neurobiology

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Section: Vitamin Dmentioning

confidence: 96%

Driving GDNF expression: The green and the red traffic lights

Saavedra

Baltazar

Duarte

2008

Progress in Neurobiology

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“…Çalışmalarda vitamin D 3 'ün nitrit oluşumunu azalttığı ve gama glutamil transpeptitaz ekspresyonunu arttırarak oksidatif stresi azalttığı gösterilmiştir (56). Ayrıca in vivo çalışmalarda orta serebral arter tıkanıklığı sonrası kortikal enfarktı azalttığı gözlenmiştir (57). Bu bulgulardan yola çıkarak yapmış olduğumuz çalışmamızda fonksiyonel iyileşmeyi değerlendirdiğimiz eğik düzlem testi sonucunda, vitamin D 3 uygulanan ilaç grubunda verilen ilacın etkisiyle birinci haftadan itibaren artış gözlendi.…”

Section: Discussionunclassified

“…Vitamin D 3 karaciğerde aktif formu olan kalsidiole, vitamin D 2 de aktif formu 25(OH)D 2 formuna dönüşmektedir (7)(8)(9). Vitamin D 3 'ün biyolojik fonksiyonları, kalsiyum dengesinin düzenlenmesi, sinir siteminde hücre diferansiasyonu, nötrofillerin salınımı ve nörotransmitter sentezinde anahtar rol alan enzim ve genlerin aktivasyonu ile ilişkilidir (10). Beyin de vitamin D 3 etkileri açısından hedef bir dokudur.…”

Section: Introductionunclassified

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Therapeutic effects of vitamin D3 on motor functions following experimental spinal cord injury

Çelik¹,

Mutevelizade²,

Harman³

et al. 2015

tnd

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Amaç: Akut spinal kord yaralanması (SKY) sonrası nörolojik hasar, primer mekanik yaralanma ile olduğu kadar sekonder olarak doku hasarına yol açan hücre ölümü aktivasyon kaskatlarından da kaynaklanmaktadır. Bu çalışmada vitamin D 3 'ün sıçanlarda oluşturulan deneysel SKY sonrasında motor fonksiyonlar üzerindeki iyileştirici etkinliği araştırıldı. Gereç ve Yöntem:Bu çalışma Sağlık Bakanlığı Haydarpaşa Numune Eğitim ve Araştırma Hastanesi'nde yapıldı. Çalışmada 3 grupta, 7'şer adet olmak üzere toplam 21 adet Spraque-Dawley cinsi sıçan kullanıldı. İlk gruba sadece laminektomi yapıldı (kontrol grubu). İkinci gruba laminektomi yapılıp omurilik yaralanması oluşturuldu (travma grubu). Üçüncü gruba laminektomi yapılıp omurilik yaralanması oluşturuldu ve 1., 3., 5., 7. günlerde intraperitoneal olarak 1 mcg/kg/gün dozunda vitamin D 3 enjeksiyonu yapıldı (vitamin D 3 grup). Deneklerin fonksiyonel iyileşmeleri cerrahi işlem sonrası 1., 7., 14. ve 21. günlerde eğik düzlem testi, Drummond ve Moore motor fonksiyon skoru ile değerlendirildi. Kontrol, travma ve vitamin D 3 uygulanan gruplardaki doku parçaları hematoksileneozin (HE) boyası ile boyanıp ışık mikroskobunda incelendi. Bulgular: Vitamin D 3 grubunda eğik düzlem testi sonuçları ve motor fonksiyon skorları travma grubu ile karşılaştırıldığında 1., 2. ve 3. haftalarda anlamlı olarak daha yüksek bulundu. Objective: Spinal cord injuries are frequently encountered and is a major health problem due to the severe disability they cause. The neurological damage of acute spinal cord trauma triggers primary mechanisms of injury and cell death activation cascades leading to tissue damage. The aim of this study was to investigate the therapeutic effects of vitamin D 3 in a rat model of spinal cord injury. Materials and Methods:The study was performed at Haydarpaşa Numune Training Hospital, İstanbul, Turkey. Twenty-one Spraque-Dawley rats were randomly assigned to the following study groups: the control group, undergoing laminectomy procedure; trauma group, undergoing spinal cord injury after laminectomy; and trauma plus vitamin D 3 group, undergoing spinal cord injury after laminectomy and subsequent administration of vitamin D 3 on days 1, 3, 5, 7 intraperitoneally with a dosage of 1 mcg/kg/day. The functional outcome was evaluated by using inclined plane test and Drummond and Moore motor function

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“…Vitamin D3 has also been shown to suppress NOS and elevate glutathione levels. In addition, vitamin D3 dramatically stimulates glial derived neurotropic factor (GDNF) production, which is neuroprotective [177].…”

Section: Prevention and Amelioration Of Asdmentioning

confidence: 99%

Immune-Glutamatergic Dysfunction as a Central Mechanism of the Autism Spectrum Disorders

Blaylock

Strunecká

2009

CMC

125

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Despite the great number of observations being made concerning cellular and the molecular dysfunctions associated with autism spectrum disorders (ASD), the basic central mechanism of these disorders has not been proposed in the major scientific literature. Our review brings evidence that most heterogeneous symptoms of ASD have a common set of events closely connected with dysregulation of glutamatergic neurotransmission in the brain with enhancement of excitatory receptor function by pro-inflammatory immune cytokines as the underlying mechanism. We suggest that environmental and dietary excitotoxins, mercury, fluoride, and aluminum can exacerbate the pathological and clinical problems by worsening excitotoxicity and by microglial priming. In addition, each has effects on cell signaling that can affect neurodevelopment and neuronal function. Our hypothesis opens the door to a number of new treatment modes, including the nutritional factors that naturally reduce excitotoxicity and brain inflammation.

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Vitamin D3 attenuates cortical infarction induced by middle cerebral arterial ligation in rats

Cited by 183 publications

References 38 publications

Driving GDNF expression: The green and the red traffic lights

Driving GDNF expression: The green and the red traffic lights

Therapeutic effects of vitamin D3 on motor functions following experimental spinal cord injury

Immune-Glutamatergic Dysfunction as a Central Mechanism of the Autism Spectrum Disorders

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