Vitamin E Ameliorates Some Biochemical Parameters in Normal and Diabetic Rats

Abstract

Diabetes is associated with hyperglycemia, one of the most important causes of oxidative stress. Endogenous antioxidants are able to destroy the reactive species and create a balance between antioxidant and free radicals. In diabetes, the oxidative stress is increased due to the deficiency in the antioxidant defense. The intake of antioxidants, such as vitamin E, may reduce the oxidative stress associated with diabetes and hence help to restore the antioxidant defense system. The aim of this article was to investigate the effect of different doses of vitamin E on the biochemical parameters of normal and streptozotocin (STZ)-induced diabetic rats. Biochemical analysis was used to study the effect of this vitamin on the biochemical parameters of normal and diabetic rats. The plasma levels of alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactic dehydrogenase (LDH), and gamma-glutamyl transferase (gamma-GT) were significantly increased after the onset of diabetes. In addition, STZ-induced diabetes also caused an increase in the level of blood urea nitrogen (BUN) and creatinine. Oral administration of vitamin E (0.2-0.4 mg daily) significantly (P < 0.05) decreased the plasma level of ALT, AST, and gamma-GT. In addition, there was a slight but not significant reduction in the plasma level of ALP. Parameters of kidney function, such as BUN and creatinine, were slightly reduced after the oral administration of vitamin E. The plasma level of electrolytes, such as calcium and sodium, also changed significantly (P < 0.00001) after the oral administration of vitamin E. Vitamin E ameliorates the metabolic and biochemical parameters of diabetic rats.

Diabetic Bladder Dysfunction: Current Translational Knowledge

“…Intake of antioxidants, such as vitamin E 24 and α-lipoic acid 25 , which functions as a cofactor in multi-enzyme complexes, have been successfully used to reverse the oxidative stress produced by hyperglycemia in human diabetics and in STZ-induced diabetic animal models. Oral treatment of α-lipoic acid (600 mg per day orally for five weeks) improved neuropathic deficits in diabetic patients with distal symmetric polyneuropathy in a recent clinical trial 25 .…”

Evaluation of oxidative stress-induced diabetic complications on alloxan-treated hyperglycaemic rats, using some biochemical parameters and histological profiles of three major organs

“…The pathological changes in liver of alloxan and streptozotocin induced diabetic animals have been previously reported Herrman & Sandhu et al 50,51 Zhang et al 52 reported an increased serum levels of ALT and AST in diabetic rats. Ohaeri, 53 Al-shamshi et al; 54 Fadillioglu et al 55 also reported an increased serum ALT and AST in diabetes patients than in the general population (Figures 1-4). The results of this study however disagree with the results of Jianpu et al 56 who reported that serum ALT and AST levels in diabetic rabbits were within normal ranges and Gidado et al 21 who reported insignificant changes in serum levels of ALT and AST in diabetic rats.…”

Nociceptin Increases Antioxidant Expression in the Kidney, Liver and Brain of Diabetic Rats

“…Studies using supplements of enzymatic endogenous antioxidants such as SOD, CAT, and glutathione peroxidase to treat diseases have been reported [16,17]. Many studies have also been performed looking into the ability of non-enzymatic antioxidants (vitamin C, E, tocopherol) to either prevent and/or cure a large variety of diseases, including diabetes mellitus [18,19]. These reports showed that vitamin C and E have beneficial effects on the outcome of diseases [18][19][20][21][22][23].…”