Vitamin E analog, alpha-tocopherol ether-linked acetic acid analog, alone and in combination with celecoxib, reduces multiplicity of ultraviolet-induced skin cancers in mice

Abstract

The goals of this study were to determine whether alpha-tocopherol ether-linked acetic acid analog (alpha-TEA), a novel vitamin E analog, and celecoxib, alone or in combination, when administered as a late intervention can reduce the ultraviolet-induced nonmelanoma skin-tumor burden of established tumors, prevent additional tumors from developing, and prevent tumor recurrence once treatments are stopped. Hairless SKH-1 female mice were ultraviolet-irradiated for 24 weeks, divided into treatment groups so that each group had approximately 5.8 tumors/mouse, and then treated with 72 mug of liposome-formulated alpha-TEA by aerosol inhalation, 500 p.p.m. celecoxib in AIN-76 A diet, or a combination of alpha-TEA and celecoxib for 4 weeks. At the end of 4 weeks of treatment, each treatment group was subdivided, with one subgroup continuing to receive treatment and with treatment being stopped in the other. Skin-tumor development was monitored visually throughout the study and by histologic evaluation at the end. After 4 weeks of treatment, all treatments showed statistically significant reductions in tumor number when compared with controls. After termination of treatment, only alpha-TEA prevented a significant increase in tumor recurrence; however, continuous combination treatment resulted in the lowest total number of tumors. In conclusion alpha-TEA is an effective late-stage chemopreventive agent for nonmelanoma skin cancer that exhibits lasting benefits.

Liposomal delivery systems for anti-cancer analogues of vitamin E

“…Synergetic anti-cancer effect was observed even if platinum-resistant tumor was used [83]. The developed aerosol formulation of liposomal α-TEA was successfully combined with liposomal 9-nitro-camptohecin, liposomal paclitaxel or celecoxib to reduce tumor burden as well as lung and lymph node metastases in various animal cancer models [84][85][86][87].…”

Topical application of Nexrutine inhibits ultraviolet B‐induced cutaneous inflammatory responses in SKH‐1 hairless mouse

“…Photo‐chemoprevention by natural compounds ameliorates the adverse effects of UVB on the skin and considers as an alternative strategy to control the photocarcinogenesis process . Topical application of natural compounds has long been known to protect skin from oxidative damage . Moreover, due to their anti‐inflammatory properties, it can be used for the treatment of inflammation‐associated skin damage .…”

Potential of Resveratrol in Inhibiting Cancer and Slowing Aging

“…Interest in phytopharmaceuticals is accelerating since a growing group of studies has indicated that nutritional factors play an important role in many human diseases. Large and heterogeneous groups of botanicals, nutraceuticals and herbal drugs have been identified and evaluated during recent years, especially for their activities against cancer [1][2][3][4][5][6][7][8][9][10][11][12][13]. These agents include curcumin from turmeric, green tea polyphenols, boswellic acid from genus Boswellia, genistein from soybean, vitamin E, rosmarinic acid from rosemary and lavender, 6-shoagol from ginger rhizome and resveratrol from berries, which will be primarily introduced in this review.…”