Vitamin E and <i>Hippophea rhamnoides</i> L. extract reduce nicotine‐induced oxidative stress in rat heart

Background:The aim of this study was to investigate the possible protective role of antioxidant treatment with ellagic acid (EA) on lung injury after intestinal ischemia-reperfusion (I/R) injury using biochemical and histopatological approaches.Materials and Methods:Forty rats were divided into four groups as control, control + EA, I/R, and I/R + EA. The control and control + EA groups were also anesthetized and subjected to laparotomy, but without clamp application. The control + EA and I/R + EA groups were given EA (85 mg/kg) orally prior to experiment. The I/R and I/R + EA groups underwent 30 minutes of intestinal ischemia and 1 hour of reperfusion. In all groups, serum total antioxidant capacity (TAC) and malondialdehyde (MDA) levels were determined. TAC, total oxidative status (TOS), and oxidative stress index (OSI) in lung tissue were measured. Lung tissue histopathology was also evaluated by light microscopy.Results:TAC levels were higher in control, EA, and I/R + EA groups while TOS, OSI, and MDA levels were lower in these groups compared with I/R group. Serum MDA levels were significantly higher in I/R + EA group than that of control group. Lung tissue TAC levels were lower in I/R + EA group while OSI values were higher in that groups compared with EA group. Histological tissue damage was milder in the EA treatment group than in the I/R group.Conclusion:These results suggest that EA treatment protected the rats lung tissue against intestinal I/R injury.

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“…In addition, lipid peroxides may inhibit protein synthesis, block macrophage function, and alter chemotactic activity. [4112627]…”

Section: Discussionmentioning

confidence: 99%

Ellagic acid ameliorates lung injury after intestinal ischemia-reperfusion

Böyük¹,

Önder²,

Kapan³

et al. 2011

Phcog Mag

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“…For example, Geetha et al (2008) showed that the sea buckthorn leaf extract has a significant hepato-protective effect which was attributed to the antioxidant compounds present in the extract. Similarly, Gumustekin et al (2010) studied the effects of nicotine-induced oxidative stress in rat heart with vitamin E and sea buckthorn extract. The authors showed that supplementation of extract increased superoxide dismutase and glutathione S-transferase activities, which may be contributing to the prevention of nicotine-induced oxidative stress in rat heart.…”

Section: Introductionmentioning

confidence: 99%

Sea buckthorn seed oil protects against the oxidative stress produced by thermally oxidized lipids

Zeb

Ullah

2015

Food Chemistry

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“…[13] In addition, Vitamin E has been shown to be cardioprotective against peroxidative damage induced by tobacco smoke. [1415] Ozone is a very reactive gas and is well known as a potent oxidant. [16] However, recent studies have clearly shown that a small and precisely ozone dose can induce upregulation of antioxidant enzymes.…”

Section: Introductionmentioning

confidence: 99%

Ovarian Damages Produced by Aerosolized Fine Particulate Matter (PM2.5) Pollution in Mice

Gai

Qian

et al. 2017

Chinese Medical Journal

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Background:Ambient aerosol fine particulate matter (PM2.5) is associated with male reproductive toxicity in experiments and may have adverse effects in the female. However, studies evaluating the protective effects and precise mechanisms of aspirin, Vitamin C, Vitamin E, or ozone against toxic effects of PM2.5 are sparse. This study was conducted to investigate the possible protective effects and mechanisms of aspirin, Vitamin C, Vitamin E, or ozone on fertility in female mice treated with PM2.5.Methods:Eighty-four ICR mice were divided into six groups: control group, PM2.5 group, PM2.5 + aspirin group, PM2.5 + Vitamin C group, PM2.5 + Vitamin E group, and PM2.5 + ozone group. PM2.5 was given by intratracheal instillation every 2 days for 3 weeks. Aspirin, Vitamin C, and Vitamin E were given once a day by oral gavage for 3 weeks, and ozone was administered by intraperitoneal injection once a day for 3 weeks. The levels of anti-Müllerian hormone (AMH), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and 8-hydroxy-2’-deoxyguanosine (8-OHdG) were measured using enzyme-linked immunosorbent assay. Western blotting analysis was used to analyze the expressions of Bcl-2, Bax, and caspase-3 in ovaries. Changes in histological structure were examined by light microscope and electron microscopy was used to detect ultramicrostructure.Results:The results demonstrated that PM2.5 decreased AMH levels (P < 0.001); however, aspirin (P < 0.001), Vitamin C (P < 0.001), Vitamin E (P = 0.001), and ozone (P = 0.002) alleviated the decrease. Changes of IL-6, TNF-α, 8-OHdG, Bax/Bcl-2, and caspase-3 in PM2.5 group were increased compared to control group (P < 0.001), while in PM2.5 + aspirin, PM2.5 + Vitamin C, PM2.5 + Vitamin E, and PM2.5 + ozone groups, they were statistically decreased compared to PM2.5 group (P < 0.001 or P < 0.05).Conclusions:PM2.5 cause the damage of ovaries, and aspirin, Vitamin C, Vitamin E, and ozone antagonizes the damage. The protective mechanism is probably due to its ability to blunt the inflammatory and oxidative stress caused by PM2.5, which subsequently suppressing the expression of apoptotic regulatory protein and reducing the incidence of ovary apoptosis.

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Vitamin E and Hippophea rhamnoides L. extract reduce nicotine‐induced oxidative stress in rat heart

Cited by 40 publications

References 34 publications

Ellagic acid ameliorates lung injury after intestinal ischemia-reperfusion

Ellagic acid ameliorates lung injury after intestinal ischemia-reperfusion

Sea buckthorn seed oil protects against the oxidative stress produced by thermally oxidized lipids

Ovarian Damages Produced by Aerosolized Fine Particulate Matter (PM2.5) Pollution in Mice

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