Vitamin E and premature labor

Shute, Evan

doi:10.1016/s0002-9378(42)90599-4

Cited by 9 publications

(5 citation statements)

References 10 publications

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“…Vitamin E was first used by Evan Shute (1937) to control flushings, and several confirmatory reports have followed The Investigation Clinical Material.-In view of the cost (£7 per case), treatment was given only to patients seriously disabled by drenching sweats, flushings, loss of sleep, and so on. The incidence of severe flushing after cessation of menstruation is about 17%, while after radium or surgical castration the figure is 50% (McLaren, 1941).…”

Section: Unliversity Of Birminghammentioning

confidence: 99%

“…After completion of her case history and pelvic examination the patient was given blank tablets and a card to record the number of flushes at each period of the day. (Shute et al, 1938;Hain and Sym, 1943;Christy, 1945;Ferguson, 1948;Finkler, 1949). In this study special attention has been paid to the genital tract to ascertain if vitamin E is inert and therefore a substitute for oestrogens or stilboestrol in cases in which stimulation of the genital tract is undesirable.…”

Section: Unliversity Of Birminghammentioning

confidence: 99%

“…Cell-smears were also studied to ascertain if the drug was in fact inert or caused any cell division or differentiation. Shute et al (1938) and Shute (1942) have reported healing in a proportion of cases of senile vulvo-vaginitis after vitamin E, while Rubenstein (1948) and Finkler (1949) both comment on the inert or poorly developed type of vaginal smear which follows vitamin E as compared with the high degree of maturation of cells which follows stilboestrol.…”

Section: Unliversity Of Birminghammentioning

confidence: 99%

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Vitamin E in the Menopause

McLaren¹

1949

BMJ

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Section: Unliversity Of Birminghammentioning

confidence: 99%

Section: Unliversity Of Birminghammentioning

confidence: 99%

Section: Unliversity Of Birminghammentioning

confidence: 99%

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Vitamin E in the Menopause

McLaren¹

1949

BMJ

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“…Other relations, proved or suggested, exist, for example, between calcium deficiency and rickets, osteomalacia and dental caries; between iodine deficiency and colloid goitre (Yoakham, 1928); between deficiency of vitamin E and sterility or habitual abortion (Shute, 1942); between deficiency of vitamin A and puerperal sepsis (Green and Mellanby, 1928); between deficiency of vitamin C or K and accidental haemorrhage and haemorrhagic tendencies (Hellman, Shettles and Eastman, 1940). There can be no doubt about the importance of dietary deficiencies in pregnancy, and as little doubt about our ignorance of them.…”

Section: The Evidence For Nutritional Deficiencies In Pregnancymentioning

confidence: 99%

The Influence of Diet on Pregnancy and Lactation in the Mother, the Growth and Viability of the Foetus, and Post-Natal Development. Part 1. Pregnancy

Garry¹

1944

Proc. Nutr. Soc.

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Andrews): Pregnancy is a natural process and should continue so to be regarded both by the medical profession and by the lay public. Nevertheless it is probably true that pregnancy is a strain on the maternal organism, metabolically as well as physically. The factor of safety with which the human body is endowed in all its activities may be exceeded. Thus, it is possible that deficiencies, latent under conditions of normal life, may become patent during pregnancy. Moreover, we should not close our eyes to the fact that our social system is such that this period of inevitable, natural, physiological strain is too often accompanied by financial stringency. The increased demands of pregnancy and of motherhood are not met by increased provision of help in the home.Although much attention has been paid to the grosser catastrophes and mechanical difficulties of pregnancy and of labour we are still woefully ignorant of the more subtle metabolic changes associated with the nutrition of the unborn child. We have barely begun to understand the role of the placenta in conveying food materials and oxygen to, and removing waste from, the foetus. In addition, the placenta seems to act as a temporary maternal ductless gland. Thus, true appreciation of the importance of proximate principles and of accessory food factors must wait on greater knowledge of placental and foetal metabolism.All we can hope to do a t present is to record observations, to rely on frank empiricism. From studies of experimental and of farm animals, and from the experiences of mankind, we are accumulating data concerning nutrition with reference to successful pregnancy. But, until such knowledge becomes truly scientific, we shall fail to resolve our uncertainties, dispose of controversy, check the excesses of the less critical enthusiasts and gain the wholehearted support of the more sceptical among us. We are at present unable to aseess accurately the causes of wastage of young life, both in lower animals and in man; during pregnancy and in the neo-natal period. Statistics show that such wastage is serious. It is our task to try to find the part played by proper nutrition in ensuring normal pregnancy and viable healthy offspring. 226Cambridge Core terms of use, available at https://www.cambridge.org/core/terms. https://doi

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“…Previously vitamin E treatment (VET) was used for the prevention of pregnant women with recurrent and threatened abortion, in addition with threatened premature labor, but no effect of VET was demonstrated in some studies [4][5][6], though the beneficial effect of VET for fetal growth was also shown [7].…”

Section: Introductionmentioning

confidence: 99%

Birth Outcomes of Pre-Eclamptic Pregnant Women With Vitamin E Supplementation A Population-Based Study

Bártfai¹,

Czeizel²,

Bánhidy³

2011

Open Drug Saf J

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Abstract:Objectives. To study the efficacy of vitamin E supplementation for the reduction of preterm birth/low birthweight newborns in pre-eclamptic pregnant women. Design. Comparison of the rate of preterm birth and low birthweight in pre-eclamptic pregnant women with or without vitamin E treatment. Setting. Hungarian Case-Control Surveillance System of Congenital Abnormalities, 1980Abnormalities, -1996. Population. Newborn infants in Hungarian population. Methods. Medically recorded pre-eclampsia and birth outcomes of pregnant women were evaluated. Main outcome measures. Preterm birth, low birthweight. Results. There was no lower incidence of pre-eclampsia after vitamin E treatment. Pregnant women with pre-eclampsia and without vitamin E treatment had a higher rate of preterm births (10.4% vs. 9.3%) and low birthweight newborns (7.8% vs. 5.6%) than the reference sample of 34,928 pregnant women without pre-eclampsia and without vitamin E treatment. The newborns of 936 pregnant women with pre-eclampsia and without vitamin E treatment had higher rate of preterm birth (10.4% vs. 8.6%; OR with 95% CI: 0.8, 0.7-0.9) than 81 pregnant women with pre-eclampsia but with vitamin E treatment. However, the rate of low birthweight newborns was somewhat but not significantly higher (8.6% vs. 7.8%; OR with 95 CI: 1.1, 0.8-1.4) in pregnant women with pre-eclampsia and with vitamin E treatment. There was very high rate of threatened abortion (45.7% vs. 15.3%) and threatened preterm delivery (27.2% vs. 13.5%) in 81 preeclamptic pregnant women with vitamin E treatment compared to the reference group. Conclusions. Vitamin E treatment reduced the rate of preterm birth in pregnant women with pre-eclampsia but not the rate of low birthweight newborns.

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Vitamin E and premature labor

Cited by 9 publications

References 10 publications

Vitamin E in the Menopause

Vitamin E in the Menopause

The Influence of Diet on Pregnancy and Lactation in the Mother, the Growth and Viability of the Foetus, and Post-Natal Development. Part 1. Pregnancy

Birth Outcomes of Pre-Eclamptic Pregnant Women With Vitamin E Supplementation A Population-Based Study

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