Vitamin E deficiency in South Asian population and the therapeutic use of alpha-tocopherol (Vitamin E) for correction of anemia

Jilani, Tanveer; Iqbal, Mohammad Perwaiz

doi:10.12669/pjms.346.15880

Cited by 25 publications

(24 citation statements)

References 31 publications

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“…Interestingly, Zhang, Ni, and Hu () showed similar positive correlation between MCH and retinol levels (Zhang, Ni, & Hu, 2018). Tocopherol has been shown to prevent cell membrane from being damaged by reactive oxygen species to maintain red blood cell integrity and increase the number of erythroid colony forming units in bone marrow (Jilani & Iqbal, ). Notably, despite the insignificant difference, the rate of anaemia in α‐tocopherol sufficient group was lower than that of α‐tocopherol deficient group in our study, which suggests a potential functional connection between α‐tocopherol level and haematopoiesis.…”

Section: Discussionmentioning

confidence: 99%

Retinol and α‐tocopherol in pregnancy: Establishment of reference intervals and associations with CBC

Liu

Zhan

Jia

et al. 2020

Maternal & Child Nutrition

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Profound physiological changes during pregnancy may affect the requirement of retinol and tocopherol, which are essential micronutrients for the maintenance of maternal health and foetal development. However, the current reference intervals (RIs) of retinol and tocopherol are based on non‐pregnant population. In the present study, a liquid chromatography–tandem mass spectrometry quantitation method for serum retinol and α‐tocopherol was established and validated. In addition, we established trimester‐specific RIs of retinol and α‐tocopherol using the data from paired screening test for 31,301 outpatients who participated in the prenatal vitamins A/E evaluation program at our hospital using the Hoffmann method, which is a simple indirect RI estimation method that does not require the recruitment of healthy subjects. Further, to explore the associations between the levels of retinol and α‐tocopherol and the parameters of complete blood count (CBC), the results of retinol, α‐tocopherol, and CBC of 1,977 pregnant outpatients in the third trimester were analysed. The testing interval between the levels of vitamins and CBC was no more than 7 days. Although no significant changes were noticed in the levels of retinol, the α‐tocopherol levels continuously increased with normal physiological changes throughout pregnancy. Lower retinol levels were associated with the higher incidence of anaemia, whereas higher levels of retinol and lower levels of α‐tocopherol were associated with higher platelet count.

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Section: Discussionmentioning

confidence: 99%

Retinol and α‐tocopherol in pregnancy: Establishment of reference intervals and associations with CBC

Liu

Zhan

Jia

et al. 2020

Maternal & Child Nutrition

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“…Studies regarding the VE status in healthy schoolchildren in developing countries are scarce, although some authors believe that it is a prevalent deficiency, with important consequences, like anemia 19 . Part of this situation could be attributed to the fact that the VE normal range criterion for serum levels among children has been a cause of concern 20 .…”

Section: Discussionmentioning

confidence: 99%

Vitamin E deficiency and associated factors among Brazilian school children

Custodio

Nogueira‐de‐Almeida

Ciampo

et al. 2020

Medicina (Ribeirão Preto)

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Objective: Brazilian national data show a significant deficiency in pediatric vitamin E consumption, but there are very few studies evaluating laboratory-proven nutritional deficiency. The present study aimed to settle the prevalence of vitamin E deficiency (VED) and factors associated among school-aged children attended at a primary health unit in Ribeirão Preto (SP). Methods: A cross-sectional study that included 94 children between 6 and 11 years old. All subjects were submitted to vitamin E status analysis. To investigate the presence of factors associated with VED, socioeconomic and anthropometric evaluation, determination of serum hemoglobin and zinc levels, and parasitological stool exam were performed. The associations were performed using Fisher's exact test. Results: VED (α-tocopherol concentrations <7 μmol/L) was observed in seven subjects (7.4%). None of them had zinc deficiency. Of the total of children, three (3.2%) were malnourished, 12 (12.7%) were anemic, and 11 (13.5%) presented some pathogenic intestinal parasite. These possible risk factors, in addition to maternal-work, maternal educational level, and monthly income, were not associated with VED. Conclusions: The prevalence of VED among school-aged children attended at a primary health unit was low. Zinc deficiency, malnutrition, anemia, pathogenic intestinal parasite, maternal-work, maternal educational level, and monthly income were not a risk factor for VED.

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“…Deficiency resulting from inadequate consumption of vitamin E rarely occurs in the setting of severe malnutrition. [156][157][158][159]…”

Section: Poor Intakementioning

confidence: 99%

Nutritional neuropathies

Gwathmey

Grogan

2019

Muscle and Nerve

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Neuropathies associated with nutritional deficiencies are routinely encountered by the practicing neurologist. Although these neuropathies assume different patterns, most are length‐dependent, sensory axonopathies. Cobalamin deficiency neuropathy is the exception, often presenting with a non–length‐dependent sensory neuropathy. Patients with cobalamin and copper deficiency neuropathy characteristically have concomitant myelopathy, whereas vitamin E deficiency is uniquely associated with a spinocerebellar syndrome. In contrast to those nutrients for which deficiencies produce neuropathies, pyridoxine toxicity results in a non–length‐dependent sensory neuronopathy. Deficiencies occur in the context of malnutrition, malabsorption, increased nutrient loss (such as with dialysis), autoimmune conditions such as pernicious anemia, and with certain drugs that inhibit nutrient absorption. When promptly identified, therapeutic nutrient supplementation may result in stabilization or improvement of these neuropathies.

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Vitamin E deficiency in South Asian population and the therapeutic use of alpha-tocopherol (Vitamin E) for correction of anemia

Cited by 25 publications

References 31 publications

Retinol and α‐tocopherol in pregnancy: Establishment of reference intervals and associations with CBC

Retinol and α‐tocopherol in pregnancy: Establishment of reference intervals and associations with CBC

Vitamin E deficiency and associated factors among Brazilian school children

Nutritional neuropathies

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