Vitamin E Deficiency in the Monkey. IV. Further Studies of the Anemia with Emphasis on Bone Marrow Morphology

Fs, Porter; Cd, Fitch; Js, Dinning

doi:10.1182/blood.v20.4.471.471

Cited by 59 publications

(7 citation statements)

References 10 publications

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“…Animal studies have observed the development of severe anaemia and morphological abnormalities of the bone marrow among primates on long-term vitamin E-de®cient diets 130,131 . Treatment with vitamin E stimulated reticulocytosis and improved blood parameters among these animals 132 . Abnormal erythropoiesis, impaired iron metabolism and decreased erythrocyte survival times have also been observed in vitamin E-de®cient animals 130,133,134 .…”

Section: Vitamin Ementioning

confidence: 86%

The role of vitamins in the prevention and control of anaemia

Fishman

Christian

West

2000

Public Health Nutr.

264

208

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Objective: While iron de®ciency is regarded as the major cause of nutritional anaemia, changes in vitamins A, B 12 , C and E, folic acid and ribo¯avin status have also been linked to its development and control. This paper provides a systematic review of vitamin supplementation trials relating to the control of nutritional anaemia. Methods: A MEDLINE search was used to ®nd reports of vitamin supplementation trials that reported changes in anaemia or iron status. Results: Vitamin A can improve haematological indicators and enhance the ef®cacy of iron supplementation. Both folate and vitamin B 12 can cure and prevent megaloblastic anaemia. Ribo¯avin enhances the haematological response to iron, and its de®ciency may account for a signi®cant proportion of anaemia in many populations. Vitamin C enhances the absorption of dietary iron, although population-based data showing its ef®cacy in reducing anaemia or iron de®ciency are lacking. Vitamin E supplementation given to preterm infants has not reduced the severity of the anaemia of prematurity. Vitamin B 6 effectively treats sideroblastic anaemia. Multivitamin supplementation may raise haemoglobin (Hb) concentration, but few studies have isolated the effect of multivitamins from iron on haematological status. Conclusions: In general, the public health impact of vitamin supplementation in controlling anaemia is not clear. Neither are the complex interactions involving multiple vitamins in haematopoiesis suf®ciently understood to explain the observed variability in haematological responses to vitamins by age, population, vitamin mixture and dosages. Further research is needed to understand the roles of individual and combined vitamin de®ciencies on anaemia to design appropriate micronutrient interventions to prevent anaemia.

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Section: Vitamin Ementioning

confidence: 86%

The role of vitamins in the prevention and control of anaemia

Fishman

Christian

West

2000

Public Health Nutr.

264

208

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“…Experimental induction of vitamin E deficiency in Maeaea [asdeularis, Cebus alb/frons and Cebus apella resulted in a progressive macrocytic haemolytic anaemia together with other features of vitamin E deficiency which were not necessarily related to the anaemia and which included skeletal muscle degeneration (Ausman & Hayes, 1974;Hayes, 1974). Experimental induction of vitamin E deficiency in rhesus monkeys (Macaca mulatta) also induced an anaemia and a muscular dystrophy (Dinning & Day, 1957;Porter, Fitch & Dinning, 1962;Fitch et al, 1965) and it was concluded that the anaemia was due to impaired production as well as decreased life span of red blood cells. Skeletal muscle myopathy has also been produced in squirrel monkeys (Saimiri sciureus) by selenium deficient diets (Muth, Weswig, Whanger & Oldfield, 1971).…”

Section: Discussionmentioning

confidence: 99%

A survey of the pathology of marmosets (Callithrix jacchus) derived from a marmoset breeding unit

Chalmers¹,

Murgatroyd²,

Wadsworth³

1983

Lab Anim

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The results of a survey of the major pathological conditions encountered in an established breeding colony of common cotton-eared marmosets (Callithrix jacchus) is presented. 265 home-bred and 70 imported wild-caught marmosets were examined. A Heinz body haemolytic anaemia and skeletal muscle myopathy were the most common pathological findings and were considered to be a result of a complex nutritional deficiency involving vitamin E, selenium and protein. Inflammatory disease of the intestinal tract was also a major feature. Chronic colitis was particularly common in older marmosets. Pneumonia, otitis media, meningitis and brain abscesses were important pathological findings in home-bred marmosets and were commonly associated with bacterial infections, particularly Bordetella bronchiseptica and Klebsiella species. Trichospirura leptostoma within pancreatic ducts of wild-caught marmosets was the only significant parasitic disease encountered. Mycotic infections of the upper alimentary tract with Candida species were occasional findings in debilitated animals. No pathological features suggesting viral diseases were found.

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“…Two possible explanations for this are: the defect could be shared by all erythroid cells including reticulocytes, but be apparent only in the more immature erythroid precursor because it normally synthesizes thirty times as much porphyrin as the reticulocyte (Table 1); or, those cells that leave the bone marrow as reticulocytes and get into the peripheral blood could have been able to synthesize porphyrin in normal amounts throughout their maturation. In support of the latter possibility is the fact that mature erythrocytes from deficient animals are not hypochromic or microcytic (Porter et al 1962) as would be expected if haemoglobin synthesis in these cells had been defective. This possibility might also help explain the high bone marrowfree protoporphyrin concentrations in the deficient animals.…”

Section: Discussionmentioning

confidence: 90%

“…Decreased porphyrin synthesis could not be correlated with the degree of the characteristic morphologic abnormality of the erythroid cell of the vitamin E-deficient monkey (Porter et al 1962). Some fluorescent cells were present in the incubated bone marrow samples from deficient animals and fluorescence was seen in a few multinucleated erythroid precursors as well as in the more normal appearing ones.…”

Section: Porphyrin Synthesismentioning

confidence: 81%

Vitamin E Deficiency in The Monkey X. Protoporphyrin and Haeme Synthesis by Peripheral Blood and Bone Marrow

Porter¹,

Fitch²

1966

Scandinavian Journal of Haematology

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In vitro studies of porphyrin and haeme synthesis by bone marrow cells from vitamin E‐deficient monkeys indicate that vitamin E is required for the normal synthesis of these compounds. The defect in porphyrin synthesis apparently results from abnormal delta‐aminolaevulinic acid synthesis. This defect was not found in the reticulocytes of peripheral blood. The administration of vitamin E corrected the abnormality in porphyrin synthesis, but the addition of vitamin E in vitro did not. Coenzyme Q10 administration also resulted in increased porphyrin synthesis by the bone marrow cells of vitamin E‐deficient monkeys.

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Vitamin E Deficiency in the Monkey. IV. Further Studies of the Anemia with Emphasis on Bone Marrow Morphology

Cited by 59 publications

References 10 publications

The role of vitamins in the prevention and control of anaemia

The role of vitamins in the prevention and control of anaemia

A survey of the pathology of marmosets (Callithrix jacchus) derived from a marmoset breeding unit

Vitamin E Deficiency in The Monkey X. Protoporphyrin and Haeme Synthesis by Peripheral Blood and Bone Marrow

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