Vitamin E in Human Health and Oxidative Stress Related Diseases

Abstract

Oxidative stress characterized by an imbalance in the production and degradation of radical species has been implicated in the onset and progression of several diseases. The efficacy of antioxidants acting via the inhibition of radical chain reactions, scavenging of free radicals, direct donation of electrons to radical species and chelation of metal ions have been reported to attenuate the oxidative process. Vitamin E is an effective antioxidant and its hydrophobic nature and membrane permeability offer some benefits to application and bioavailability. This chapter highlights the following; structural differences in the vitamin family, biosynthesis in plants and the native biological role, antioxidant mechanisms of vitamin E, an overview of the prophylactic action of vitamin E as well as the effect on the oxidative process in some diseases.

Enhanced stability of natural vitamin E from palm oil by forming inclusion complexes with cyclodextrin and its application on PLA fabric

“…However, the applications of vitamin E are limited by its poor water solubility and susceptibility to degradation caused by environmental factors such as light, oxygen, and high pH. [9][10][11] Several techniques have been developed to recover vitamin E from palm oil. These include solvent extraction, [12][13][14] enzymatic process, [15][16][17] chemical modification through esterification 18 and molecular distillation.…”

Interaction between Vitamins C and E When Scavenging the Superoxide Radical Shown by Hydrodynamic Voltammetry and DFT

“…All naturally occurring vitamin E forms are strong antioxidants with anti-inflammatory activities [33]. A recent review describes the capability of vitamin E to behave as an antioxidant and its effects on diseases caused by oxidative stress [34]. However, despite many studies that have reported on vitamin E's relationship with the immune system, the mechanistic details are lacking [35,36].…”

Histopathological evaluation of the effect of vitamin E on reversing changes induced by Tartrazine in parotid glands of albino rats

“…It acts as the first line of defense against lipid peroxidation, protecting the cell membranes from free radical attack. 6 Vitamin E also possesses anti-cancer properties. This is probably because of its ability to stimulate the p53 tumor suppressor gene; the downregulation of mutant p53 proteins and his anti-angiogenic effect mediated by the blockage of transforming growth factor alpha.…”