VITAMIN E INHIBITS THE HIGH-FAT DIET PROMOTED GROWTH OF ESTABLISHED HUMAN PROSTATE LNCaP TUMORS IN NUDE MICE

Abstract

These data suggest that the mechanism of dietary fat induced growth of human prostate cancer cells is mediated by oxidative stress. It also raises the possibility of a therapeutic benefit of vitamin E in preventing prostate cancer.

Resveratrol-Induced Gene Expression Profiles in Human Prostate Cancer Cells

“…Whether resveratrol acts directly as an antiandrogen by binding to the AR, or indirectly through its estrogenic effects, awaits further study. Other putative prostate cancerpreventive agents, including vitamin E, lycopene, and methylselenic acid, an organic selenium compound, have been reported to modulate androgen signaling in LNCaP cells through unknown mechanisms (44)(45)(46)(47)(48)(49).…”

Chemoprevention of Prostate Cancer through Dietary Agents: Progress and Promise

“…Decreased expression of tocopherol-associated protein in human CaP tissue points to its role in tumor suppression (26). An in vivo study showed growth inhibition of established prostate LNCaP tumors in nude mice on dietary supplementation of tocopheryl acetate (27). A more recent study showed a significant reduction in CaP incidence in male Lady transgenic mice fed with a diet supplemented with Vitamin E succinate, selenium, and lycopene (28).…”

Selenium and Vitamin E for Prostate Cancer: Post-SELECT (Selenium and Vitamin E Cancer Prevention Trial) Status

“…Given orally, 11.4 mg/kg/d all-rac α-tocopheryl acetate was reported to attenuate dietary fat-exacerbated LNCaP tumor growth in nu/nu mice, but did not have an effect on tumor growth in animals fed a low-fat diet (54). However, when intraperitoneally administered at a high dose (100 mg/kg), VES was found to retard growth of xenografted LNCaP tumors in BALB/c mice fed both high-and low-fat diets (55).…”