Vitamin E: pharmacokinetics of parenteral products and its effect on swine reproduction

Pardo, Domingo Carrión

doi:10.31274/rtd-180813-10172

Cited by 1 publication

(1 citation statement)

References 97 publications

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“…Regarding to tissue α-tocopherol concentrations, d-α-tocopherol injection increased α-tocopherol concentrations in liver, heart and muscle except for brain and lung. This result agreed with Pardo [ 12 ] that d-α-tocopherol injection to weaning pigs increased tissue α-tocopherol concentrations in liver, heart, muscle, and lung (no brain data). Interestingly, there was no difference in brain α-tocopherol concentrations by d- α-tocopherol injection even though the other tissue α-tocopherol concentrations increased.…”

Section: Discussionsupporting

confidence: 92%

Distribution of injected fat-soluble vitamins in plasma and tissues of nursery pigs

Jang

Rotering

Isensee

et al. 2020

Asian-Australas J Anim Sci

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Objective: The objective of this experiment was to investigate the effects of fat-soluble vitamin injection on plasma and tissue vitamin status in nursery pigs.Methods: A total of 16 pigs (initial body weight: 7.15±1.1 kg) were allotted to 2 treatments at d 7 post-weaning. Pigs were fed a corn-soybean meal-based basal diet with no supplemental vitamin A and i.m. injected with 300,000 IU of retinyl palmitate, 900 IU of d-α-tocopherol and 30,000 IU of vitamin D3 with control pigs having no vitamin injection. Blood (d 0, 3, 7, and 14 post-injection) and tissue samples (liver, brain, heart, lung, and muscle; d 7 and 14 post-injection) were collected from pigs. Retinyl palmitate, retinol, and α-tocopherol concentrations were analyzed in plasma and tissues, while plasma was assayed for 25-hydroxycholecalciferol (25-OHD3).Results: Plasma retinol and 25-OHD3 concentrations increased by the vitamin injection from d 3 to 14 post-injection (p<0.05) whereas plasma retinyl palmitate was detected only in the vitamin treatment at d 3 and 7 post-injection (115.51 and 4.97 μg/mL, respectively). Liver retinol, retinyl palmitate, and retinol+retinyl palmitate concentrations increased by retinyl palmitate injection at d 7 and 14 post-injection (p<0.05) whereas those were not detected in the other tissues. The d-α-tocopherol injection increased α-tocopherol concentrations in plasma at d 3 and 7 post-injection (p<0.05) and in liver, heart (p<0.10), and muscle (p<0.05) at d 7 post-injection.Conclusion: Fat-soluble vitamin injection increased plasma status of α-tocopherol, retinol, retinyl palmitate and 25-OHD3. As plasma levels decreased post-injection, vitamin A level in liver and vitamin E level in muscle, heart and liver increased. The α-tocopherol found in plasma after injection was distributed to various tissues but retinyl palmitate only to the liver.

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Section: Discussionsupporting

confidence: 92%