Vitamin E supplementation for prevention of morbidity and mortality in preterm infants

Brion, Luc P.; Bell, Edward F.; Raghuveer, Talkad S

doi:10.1002/14651858.cd003665

Cited by 230 publications

(210 citation statements)

References 123 publications

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“…High-dose parenteral vitamin E supplementation or serum levels 480 mM are not recommended (Brion et al, 2003). In the present study, four (13%) of VLBW infants in contrast to none of the NBW infants had a-tocopherol concentrations 480 mM.…”

Section: Fat-soluble Vitaminscontrasting

confidence: 55%

“…C Henriksen et al of vitamin E have been proposed as an antioxidant to limit retinopathy, cerebral hemorrhage, hemolytic anemia and chronic lung disease with sepsis as a potential toxic side effect (Brion et al, 2003). High-dose parenteral vitamin E supplementation or serum levels 480 mM are not recommended (Brion et al, 2003).…”

Section: Fat-soluble Vitaminsmentioning

confidence: 99%

“…Vitamin D has important functions in calcium-and bone homeostasis and deficiency may lead to impaired bone mineralization and eventually rickets, in addition to altered immune responses (Shils, 1999). Vitamin E acts as an antioxidant, and deficiency may cause hemolytic anemia and adversely affect development of the central nervous system in preterm infants (Azzi and Stocker, 2000;Brion et al, 2003). Vitamin K is necessary for carboxylation of proteins that are important in blood coagulation and bone formation, and deficiency may cause neonatal hemorrhage (Saxena et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

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Fat-soluble vitamins in breast-fed preterm and term infants

et al. 2006

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Objective: To examine the supply and status of fat-soluble vitamins in very low birth weight (VLBW) infants compared to a reference group of normal birth weight (NBW) infants. Design: A longitudinal study of VLBW infants in the early neonatal period. Blood samples were drawn at 1 week of age and at discharge from hospital. Plasma was analyzed for the fat-soluble vitamins: retinol, 25-OH-vitamin D, a-tocopherol and phylloquinone (vitamin K 1 ) using high-performance liquid chromatography. Subjects: A total of 40 VLBW infants were included in the study. A reference group of 33 NBW infants was randomly selected from one of our previous studies. Results: The VLBW infants received fortified human milk, and daily oral vitamin supplement (Multibionta). In VLBW infants, plasma retinol concentrations decreased and plasma 25-OH-vitamin D increased during the study period. VLBW infants had significantly lower plasma retinol (0.3 vs 0.7 mM) and higher plasma 25-OH-vitamin D (166 vs 25 nM) at discharge compared to NBW infants. Plasma phylloquinone concentration in VLBW infants was very high (53 ng/ml) at one week of age, especially in the youngest infants (192 ng/ml), but decreased rapidly during the study period resulting in low/normal plasma concentrations (0.9 ng/ml) at discharge. Conclusions: We observed alterations in plasma concentration of retinol and 25-OH-vitamin D in VLBW infants in the early neonatal period, resulting in marked differences between VLBW at discharge and NBW. Further trials are needed to evaluate whether changes in vitamin supplementation may improve clinical outcome in VLBW infants.

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Section: Fat-soluble Vitaminscontrasting

confidence: 55%

Section: Fat-soluble Vitaminsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Fat-soluble vitamins in breast-fed preterm and term infants

et al. 2006

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“…21,24 Studies show that in low income situations there is a change in food choices, characterized by the acquisition of cheaper items and with high energy density. 7,22,23 The first items that are out of the diet are usually the healthier food, which the population cannot reach the recommended quantities, such as grains of high quality protein, vegetables and greenery, extra virgin olive oil and fresh fruit, 6,22,25 some important sources of vitamin E.…”

Section: Tablementioning

confidence: 99%

“…When present, the deficiency in neonates is associated to hemolytic anemia, bilirubin, thrombocytosis, intracranial hemorrhage and retrolental fibroplasia. 6,7 There are few studies that investigate the associated factors with maternal vitamin E deficiency (DVE). Gurgel et al 8 found a high prevalence of the deficiency in women attended for the delivery in public maternities when compared to those attended at a private health network.…”

Section: Introductionmentioning

confidence: 99%

The socioeconomic variables influence in the alpha-tocopherol concentration of the maternal serum

Ribeiro

Weigert

Andrade

et al. 2017

Rev. Bras. Saude Mater. Infant.

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Interventions to Prevent Bronchopulmonary Dysplasia in Preterm Neonates

et al. 2022

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IMPORTANCE Bronchopulmonary dysplasia (BPD) has multifactorial etiology and long-term adverse consequences. An umbrella review enables the evaluation of multiple proposed interventions for the prevention of BPD. OBJECTIVE To summarize and assess the certainty of evidence of interventions proposed to decrease the risk of BPD from published systematic reviews. DATA SOURCES MEDLINE, Cochrane Central Register of Controlled Trials, EMBASE, and Web of Science were searched from inception until November 9, 2020. STUDY SELECTION Meta-analyses of randomized clinical trials comparing interventions in preterm neonates that included BPD as an outcome. DATA EXTRACTION AND SYNTHESIS Data extraction was performed in duplicate. Quality of systematic reviews was evaluated using Assessment of Multiple Systematic Reviews version 2, and certainty of evidence was assessed using Grading of Recommendation, Assessment, Development, and Evaluation. MAIN OUTCOMES AND MEASURES (1) BPD or mortality at 36 weeks' postmenstrual age (PMA) and (2) BPD at 36 weeks' PMA.RESULTS A total of 154 systematic reviews evaluating 251 comparisons were included, of which 110 (71.4%) were high-quality systematic reviews. High certainty of evidence from high-quality systematic reviews indicated that delivery room continuous positive airway pressure compared with intubation with or without routine surfactant (relative risk [RR], 0.80 [95% CI, 0.68-0.94]), early selective surfactant compared with delayed selective surfactant (RR, 0.83 [95% CI, 0.75-0.91]), early inhaled corticosteroids (RR, 0.86 [95% CI, 0.75-0.99]), early systemic hydrocortisone (RR, 0.90 [95% CI, 0.82-0.99]), avoiding endotracheal tube placement with delivery room continuous positive airway pressure and use of less invasive surfactant administration (RR, 0.90 [95% CI, 0.82-0.99]), and volume-targeted compared with pressure-limited ventilation (RR, 0.73 [95% CI, 0.59-0.89]) were associated with decreased risk of BPD or mortality at 36 weeks' PMA. Moderate to high certainty of evidence showed that inhaled nitric oxide, lower saturation targets (85%-89%), and vitamin A supplementation are associated with decreased risk of BPD at 36 weeks' PMA but not the competing outcome of BPD or mortality, indicating they may be associated with increased mortality. CONCLUSIONS AND RELEVANCEA multipronged approach of delivery room continuous positive airway pressure, early selective surfactant administration with less invasive surfactant administration, early hydrocortisone prophylaxis in high-risk neonates, inhaled corticosteroids, and volume-targeted ventilation for preterm neonates requiring invasive ventilation may decrease the combined risk of BPD or mortality at 36 weeks' PMA.

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Vitamin E supplementation for prevention of morbidity and mortality in preterm infants

Cited by 230 publications

References 123 publications

Fat-soluble vitamins in breast-fed preterm and term infants

Fat-soluble vitamins in breast-fed preterm and term infants

The socioeconomic variables influence in the alpha-tocopherol concentration of the maternal serum

Interventions to Prevent Bronchopulmonary Dysplasia in Preterm Neonates

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