Vitamin E-supplementation protect chromium (VI)-induced spermatogenic and steroidogenic disorders in testicular tissues of rats

Chandra, Amar K.; Chatterjee, A. K.; Ghosh, Rituparna; Sarkar, Mitali

doi:10.1016/j.fct.2010.01.008

Cited by 50 publications

(38 citation statements)

References 33 publications

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“…Marouani et al observed a similar effect on reproductive organs of male rats after intraperitoneal injection of potassium dichromate (1 or 2 mg/kg bw) for 15 consecutive days [23]. Chandra et al observed uniform decline in weight of testes and other accessory male sex organs after chromium (VI) treatment in male rats [17]. These observations are corroborated with a decrease in number and motility of sperm in this study.…”

Section: Discussionsupporting

confidence: 77%

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Effect of Sub-Chronic Exposure to Chromium on Haematological and Biochemical Parameters of Male Albino Rat

Saha

Choudhuri

2017

Asian J Pharm Clin Res

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Objectives: Exposure to chromium, the transition element found in many compounds of earth's crust, leads to various health hazards including cancer, dermatitis, damage of liver and kidneys, and reproductive toxicity in both male and female. Toxic effect of chronic exposure to chromium at low environmentally relevant dose is recently recognized and less studied. In the present study, we evaluated the effect of subchronic exposure to low doses of chromium VI (K 2 Cr 2 O 7 ) on various hematological and biochemical parameters in male albino rats. Methods:Male albino rats (160±10 g) received 1/25, 1/50, and 1/100 of reported oral LD 50 dose of chromium VI (K 2 Cr 2 O 7 ) for 90 consecutive days. After treatment, the blood was collected for analysis of various hematological and biochemical parameters.Results: Exposure to chromium VI at 1/25 LD 50 dose caused decrease in body weight gain and reduction in the weight of the reproductive organs along with increase in the weight of the liver and kidney. Numbers of red blood cells, white blood cells, platelets, and hemoglobin concentration reduced with increase in clotting time. The total sperm count and motility was also reduced in exposed rats. There was a decrease in plasma protein and albumin concentration, with increase in plasma glucose and cholesterol level. The activity of enzyme alanine aminotransferase and enzyme aspartate aminotransferase was stimulated in treated rats. Conclusion:The results of the present study revealed that chronic low-dose exposure to chromium VI resulted in a toxic effect in experimental male albino rats.

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Section: Discussionsupporting

confidence: 77%

“…This suggested that chronic chromium exposure resulted in a nutritional disturbance in treated rats [16]. Chandra et al observed similar decline in body weight gain after exposure to potassium dichromate for 26 days [17].…”

Section: Discussionmentioning

confidence: 56%

Effect of Sub-Chronic Exposure to Chromium on Haematological and Biochemical Parameters of Male Albino Rat

Saha

Choudhuri

2017

Asian J Pharm Clin Res

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“…Testes are target organs for oxidative stress due to its high content of polyunsaturated membrane lipid cells [40,41]. Imbalance of oxidative stress, testosterone and inflammatory markers in testes leads to impaired sperm function and infertility [42].…”

Section: Discussionmentioning

confidence: 99%

Lycopene protects against acute zearalenone-induced oxidative, endocrine, inflammatory and reproductive damages in male mice

Boeira

Funck

Filho

et al. 2015

Chemico-Biological Interactions

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“…In this study, however, no evidence of these effects was found in the testicle of the treated animals, suggesting that the valerian extract and its constituents did not interfere with the morphology of the testicle and sperm production. The height of the tubular epididymal epithelium has been used in many studies as an investigatory method of deleterious effects in reproduction (Manonayagi et al, 1989;Vawda and Mandlwana, 1990;Del Rio et al, 2003;Chandra et al, 2010). It is known that after orchiectomy, there is a diminished synthesis of RNA and proteins, reduction in the relationship nucleus/cytoplasm in the epithelial cells followed by endoplasmic reticulum and Golgi complex regression as well as regression of the organelles involved in the endocytic pathway, thus causing the reduction in the height of the tubular epididymal epithelium (Robaire et al, 2006;Cornwall, 2009;Chandra, 2010).…”

Section: Groupsmentioning

confidence: 99%

“…The height of the tubular epididymal epithelium has been used in many studies as an investigatory method of deleterious effects in reproduction (Manonayagi et al, 1989;Vawda and Mandlwana, 1990;Del Rio et al, 2003;Chandra et al, 2010). It is known that after orchiectomy, there is a diminished synthesis of RNA and proteins, reduction in the relationship nucleus/cytoplasm in the epithelial cells followed by endoplasmic reticulum and Golgi complex regression as well as regression of the organelles involved in the endocytic pathway, thus causing the reduction in the height of the tubular epididymal epithelium (Robaire et al, 2006;Cornwall, 2009;Chandra, 2010). A significant reduction in the height of the epididymal epithelium was observed in the groups treated with valerian at doses of 1000 and 2000 mg/kg, indicating that there was an anti-androgenic effect on this organ, similar as related by Robaire et al (2006) and Cornwall (2009).…”

Section: Groupsmentioning

confidence: 99%

Abnormality of spermatozoa in Wistar rats exposed to high doses of Valeriana officinalis L. aqueous suspension

Marques¹,

BrandÃ£o²,

Oshio³

et al. 2016

J. Med. Plants Res.

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Valerian (Valeriana officinalis L.) is a natural anxiolytic widely used in traditional medicine. However reproductive toxic effects have been demonstrated in mice treated with this species. This study evaluated the effect of valerian aqueous suspension on the reproductive system of Wistar rats treated for 53 days. Four groups were studied (n=25): control (1 ml of distilled water) and treated (500, 1000 or 2000 mg/kg) with the aqueous suspension per os/day. On the 54th day, 15 rats/group were killed and the following parameters were assessed: weight of reproductive organs, liver, kidneys and spleen; serum testosterone level, sperm morphology and concentration; testicle and epididymis histomorphometry. Ten other animals/group was analyzed using the dominant lethal test. There were not significant differences in body weight, hematological and biochemical parameters, weights of the liver, kidneys, spleen, reproductive organs and accessory glands between control and treated animals. The treatment with valerian did not alter the tubular and luminal diameters of the seminiferous tubules, the serum testosterone levels and the sperm viability. The sperm concentration in the epididymis cauda was not altered by the treatment although a significant increase in the number of abnormal gametes was observed in the valerian-treated animals at all dose levels when compared to control values. Significant reduction (p<0.05) in the height of the epididymal epithelium and a significant increase in the number of abnormal gametes were observed in the animals treated with the extract at 1000 and 2000 mg/kg.

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Vitamin E-supplementation protect chromium (VI)-induced spermatogenic and steroidogenic disorders in testicular tissues of rats

Cited by 50 publications

References 33 publications

Effect of Sub-Chronic Exposure to Chromium on Haematological and Biochemical Parameters of Male Albino Rat

Effect of Sub-Chronic Exposure to Chromium on Haematological and Biochemical Parameters of Male Albino Rat

Lycopene protects against acute zearalenone-induced oxidative, endocrine, inflammatory and reproductive damages in male mice

Abnormality of spermatozoa in Wistar rats exposed to high doses of Valeriana officinalis L. aqueous suspension

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