Increased fat and carbohydrate intakes based on the Western diet are important lifestyle modifications that lead to hypercaloric inputs, obesity, and male fertility negative effects. Epigenetic transmission may also predispose descended generations to chronic diseases, such as obesity, type 2 diabetes, behavioral, and reproductive disorders. The present study sought to evaluate the influence of a high-fat-high-sugar (HFHS) diet supplied to Wistar rats from 25 to 90 days of life on reproductive and metabolic parameters in male generations F0, F1, and F2. The standard group received the normocaloric – Nuvilab Quimtia® –3.86 kcal/kg. The hypercaloric diet (HD) group received the HFHS diet – PragSoluções® –4.77 kcal/kg. Body weight, adiposity, F1 and F2 prepubertal age evaluations, oral glucose tolerance test, insulin tolerance test, organ weights, sperm count and morphology assessments, and histometric testicular analyses were performed. The HFHS diet promoted dyslipidemia, higher adiposity, lower relative organ weights, and higher mean kidney weight, decreased mean testicle and parenchyma weights and lower height of seminiferous epithelium (HE) for the F0 generation. F1 and F2 offspring of HD group displayed early preprepubertal development, although did not alter the metabolic parameters. Decreased HE and tubular testicular compartment volumetric density and increased intertubular testicular compartment volumetric density and volume in the F1 generation of HD group were observed. Alterations in histometry of intertubular testicular compartment were also noted. It is concluded that the HFHS experimental model altered only paternal metabolic parameters. However, reproductive parameters of the three generations were affected.
Ginkgo biloba extract is a widely consumed phytotherapic used mainly in the treatment of dementia and Alzheimer's disease, and it has also been employed to treat erectile dysfunction and as an aphrodisiac. This work was aimed at evaluating its effect on sperm quality, serum testosterone concentration and on the histometric analysis of the testes from adult male Wistar rats. Three-month-old Wistar rats were treated with distilled water (control group) and the aqueous extract of Ginkgo biloba at the dose levels of 3.5 (GBE 3.5); 7.0 (GBE 7.0) and 14.0 mg/kg (GBE 14.0), once daily, for 56 consecutive days. Counting and morphological evaluation of sperm collected from cauda epidydimis were analyzed. Histometric measures of the testes were also taken. This work shows that adult Wistar rats exposed to Ginkgo biloba presented histometric alteration in the volume of the Leydig cells and this finding suggests a possible functional deficit in these cells.
Valerian (Valeriana officinalis L.) is a natural anxiolytic widely used in traditional medicine. However reproductive toxic effects have been demonstrated in mice treated with this species. This study evaluated the effect of valerian aqueous suspension on the reproductive system of Wistar rats treated for 53 days. Four groups were studied (n=25): control (1 ml of distilled water) and treated (500, 1000 or 2000 mg/kg) with the aqueous suspension per os/day. On the 54th day, 15 rats/group were killed and the following parameters were assessed: weight of reproductive organs, liver, kidneys and spleen; serum testosterone level, sperm morphology and concentration; testicle and epididymis histomorphometry. Ten other animals/group was analyzed using the dominant lethal test. There were not significant differences in body weight, hematological and biochemical parameters, weights of the liver, kidneys, spleen, reproductive organs and accessory glands between control and treated animals. The treatment with valerian did not alter the tubular and luminal diameters of the seminiferous tubules, the serum testosterone levels and the sperm viability. The sperm concentration in the epididymis cauda was not altered by the treatment although a significant increase in the number of abnormal gametes was observed in the valerian-treated animals at all dose levels when compared to control values. Significant reduction (p<0.05) in the height of the epididymal epithelium and a significant increase in the number of abnormal gametes were observed in the animals treated with the extract at 1000 and 2000 mg/kg.
Os gatos convivem com os seres humanos há tempos e essa relação vem se estreitando a cada dia mais, no entanto muitos problemas comportamentais são resultados de falhas ao avaliar as reais necessidades de um gato e suas condições ambientais. Esses problemas são a principal causa de abandono, levando os animais desde as ruas até a eutanásia. Nos ambientes urbanos, a presença de animais ferais vem se tornando uma grande preocupação de saúde pública, pois dos gatos ferais, somente uma reduzida parcela é vacinada ou possui um tutor responsável. O presente estudo teve como objetivo analisar as publicações científicas e traçar um perfil dos estudos feitos no Brasil sobre o tema "gatos ferais". Os dados foram coletados a partir de levantamento de estudos científicos (artigos, livros, monografias, dissertações e teses) disponibilizados digitalmente em sites de busca e de pesquisa, sendo eles Google acadêmico, Scielo, PubVet, PubMed. Foram encontrados 58 estudos científicos publicados, entre 2002 a 2019, e desses, 28 estão relacionados à temática de doenças e zoonoses, 20 relacionados a predação e impacto ambiental e, 10 a comportamento animal. O início das publicações sobre o tema foi em 2002, tendo um pico em 2015, e a região sudeste do país foi onde se concentra o maior número de estudos. Conclui-se que estudos sobre o tema são carentes, sendo necessárias pesquisas que se aprofundem mais na avaliação do comportamento dos gatos ferais.
Com o crescente número de coelhos como animais de estimação, os chamados pets não convencionais são de extrema importância que o médico veterinário esteja a par das principais afecções desses animais, bem como o seu manejo alimentar e ambiental. Estase e obstrução gastrointestinal são algumas das principais doenças que afetam esse animal, caracterizadas pela diminuição ou ausência dos pellets fecais, anorexia, dor abdominal, desconforto à palpação, sendo consideradas emergenciais, requerendo rapidez no atendimento, no diagnostico diferencial, pois demonstram sinais iguais e tratamentos diferentes, e na terapia a ser instituída, podendo ser um desafio para o médico veterinário, pois tem o tratamento complexo e resposta terapêutica lenta. Esta revisão teve como objetivo abordar sobre a estase e a obstrução gastrointestinal em coelhos domésticos.
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