Vitamin <scp>D</scp>, bone mineral density and risk of fracture in people with intellectual disabilities

Frighi, V; Morovat, Alireza; Andrews, T.M.; Rana, Faisal; Stephenson,; White, Sarah J.; Fower, E; Roast, Jan; Goodwin, Guy M.

doi:10.1111/jir.12581

Cited by 17 publications

(29 citation statements)

References 37 publications

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“…This may indicate a need for a higher serum level of 25-hydroxy vitamin D, more weight-bearing physical activity, or both. Additionally, since we did not have a control group treated with vitamin D alone, we cannot rule out the possibility that the improved BMD observed in our study was more the result of treatment with vitamin D rather than bisphosphonate, since recent reports have demonstrated suppressive effects of vitamin D on PTH and CTX in ambulatory males with intellectual disability who were never treated with bisphosphonates (Frighi et al, 2019;May & Winters, 2019).…”

Section: Discussionmentioning

confidence: 87%

Oral bisphosphonates for osteoporosis in adult males with intellectual disabilities

May

Párker

2021

Research Intellect Disabil

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Introduction: Oral bisphosphonates are first-line agents for treating osteoporosis in men, but there are no studies regarding efficacy of oral bisphosphonates for treatment of osteoporosis in ambulatory male adults with intellectual disability.Methods: Nine adult males with intellectual disability and increased fracture risk had been treated with weekly or monthly oral bisphosphonates, vitamin D and calcium for 1-3 years. Post-treatment bone mineral density (BMD), serum 25(OH)D, parathyroid hormone and C-telopeptide of type I collagen were then determined for the first time.Results: Weekly or monthly oral bisphosphonates were well tolerated and led to significant increases in BMD in all 9 individuals. Serum 25(OH)D level enhanced the "pecent increase of BMD" that occurred in response to bisphosphonate treatment (p < .05). Conclusions:Weekly or monthly oral bisphosphonates are well tolerated by ambulatory adult males with ID and are effective in increasing BMD. Higher serum levels of vitamin D appear to improve the efficacy of bisphosphonates and therefore reduce fracture risk in adult males with intellectual disability.

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Section: Discussionmentioning

confidence: 87%

Oral bisphosphonates for osteoporosis in adult males with intellectual disabilities

May

Párker

2021

Research Intellect Disabil

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“…In terms of current practice, there is evidence to suggest that long‐term vitamin D supplementation in the learning disability population is beneficial to bone health. Frighi et al () demonstrated an improvement in bone mineral density for people with learning disability previously diagnosed with vitamin D deficiency. Current guidance from the Scientific Advisory Committee on Nutrition () regarding vitamin D supplementation for the UK population recommended a Reference Nutrient Intake (RNI) for vitamin D of 10 μg daily (400 IU daily) for all aged 4 and above.…”

Section: Discussionmentioning

confidence: 99%

“…People with learning disability (LD) experience a higher rate of injuries, falls and accidents (Finlayson, Morrison, Jackson, Mantry, & Cooper, ). The rate of osteoporosis and fractures is up to three times that of the general population (Frighi et al, ).…”

Section: Introductionmentioning

confidence: 99%

Prevalence of vitamin D deficiency in people with learning disability: A systematic review

Walton

Isaac

Kerr

2019

Brit J Learn Disabil

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Accessible Summary• People with learning disability have more health problems in comparison to people without learning disability.• Low levels of vitamin D in the body is called vitamin D deficiency. This can increase the chance of bone disease, falls and broken bones.• This article has reviewed the research evidence from the last 16 years about vitamin D deficiency for people with learning disability.• The research shows that people with learning disability have an equal, and possibly higher, chance of vitamin D deficiency.• More research is needed to confirm these findings. In order to find out more about how many people with learning disability have vitamin D deficiency, a much larger study is needed. AbstractBackground: People with learning disability have increased rates of health inequality and unmet needs. Vitamin D deficiency can increase the risk of bone disease, muscle weakness and fractures. The aim of this systematic review is to assess for the prevalence of Vitamin D deficiency in people with learning disability. Method:The "Preferred Reporting Items for Systematic Reviews and Meta-analyses" checklist was followed where possible. Results:Eight studies were included in the qualitative synthesis. The quality of the studies was assessed utilising the "Appraisal of Cross-sectional Studies" tool. The prevalence of inpatients with learning disability and deficient vitamin D levels ranged from 41% to 92%. This is equal to, and likely higher than, the rate for institutionalised adults in the UK. 49%-77% of individuals with learning disability living in the community had inadequate vitamin D levels. In comparison to the general population, this is provisional evidence to suggest that people with learning disability could have an increased risk of inadequate vitamin D levels.Conclusion: Due to the low number of studies, and the heterogeneous populations of the included studies, firm conclusions could not be drawn. However, the results show that people with learning disability have at least an equal risk of vitamin D deficiency in comparison to the general population. There is provisional evidence to suggest that the prevalence could be higher for people with learning disability, and therefore, there is a need for further population-based studies.

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“…Rates of chronic disease are overall higher for individuals with intellectual disability in comparison to the general population [4,8]. One condition that is highly prevalent within this population is osteoporosis [9][10][11]. Research has sought to explore and understand the prevalence for poor bone health among people with an intellectual disability and prevalence rates of over 70% have been identified [12].…”

Section: Introductionmentioning

confidence: 99%

The Methodological Approach to the Co-Creation of Online Health Education with and for Individuals with Intellectual Disability

Burke¹

2021

GJIDD

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Background: Health inequalities are evident among adults with intellectual disability. Two large national longitudinal studies have highlighted the paucity of health education among people with intellectual disability. Frequently people with intellectual disability are excluded from health screenings, targeted health promotions and health education. Subsequently health problems often go unrecognised and unmet.Aims: Through co-creation and collaboration, the aim of this project was to develop, refine and validate resources to deliver health education on a novel digital platform in an accessible easy-read manner. The aim of this paper is to describe how the project engaged individuals online to co-create this educational offering.Methods: This is a collaborative project between Ireland and the Netherlands. The project adopts a strengths-based approach and the design adopted is citizen co-creation to promote citizen engagement and involvement in the development of this novel online programme. Individuals with intellectual disability, their carers and researchers worked in partnership to develop content, and co-design the platform. This was enabled by building familiarisation with online engagement with individuals with intellectual disability, designing and developing easy-read accessible materials and through the implementation of a robust consistent approach in both countries.Results: With the appropriate supports in place individuals with intellectual disability were capable of engaging productively and successfully with online interviewing. Many participants had experience using the internet however for many this was their first time engaging online in such a process. In total 37 participants successfully completed the online interviews and pilot-testing, contributing to the development of the content and digital education platform. Conclusion:The digital platform supports individuals with intellectual disability to be better prepared for engaging with healthcare professionals. The aims are increased confidence, and better understanding of what one can do to look after one's health. The process for developing the co-created materials identifies four critical areas for a successful project or programme: 1) establishing or utilizing relationships where a high degree of trust is in place; 2) assessing technology access and literacy levels across platforms; 3) providing skills training or other support to ensure contributors are actively and meaningfully involved across the project's lifecycle; and 4) ensuring feedback is acknowledged and used in the co-creation of both process and summative deliverables.

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Vitamin D, bone mineral density and risk of fracture in people with intellectual disabilities

Cited by 17 publications

References 37 publications

Oral bisphosphonates for osteoporosis in adult males with intellectual disabilities

Oral bisphosphonates for osteoporosis in adult males with intellectual disabilities

Prevalence of vitamin D deficiency in people with learning disability: A systematic review

The Methodological Approach to the Co-Creation of Online Health Education with and for Individuals with Intellectual Disability

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