Vitamins A, B and C in Diabetic Children

Mosenthal, Herman O.; Loughlin, Winifred C.

doi:10.1001/archinte.1944.00210170028004

Cited by 14 publications

(3 citation statements)

References 7 publications

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“…The liver vitamin A concentration and total content were found to be lower in the controls than in either the diabetic or insulin-treated diabetic group at the end of the experimental period (Table 2). DISCUSSION Decreased serum concentrations of vitamin A [2,6,7] as well as its carrier protein (RBP) have been reported in patients with diabetes mellitus [2]. We showed previously that in STZ-diabetic rats plasma vitamin A is also decreased while liver vitamin A is elevated [3], and this was confirmed in the present study.…”

Section: Resultssupporting

confidence: 89%

Influence of Insulin on Plasma and Liver Vitamin A Levels in Diabetic Rats.

Leichter

McNeill

Basu

et al. 1991

J. Clin. Biochem. Nutr.

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Section: Resultssupporting

confidence: 89%

Influence of Insulin on Plasma and Liver Vitamin A Levels in Diabetic Rats.

Leichter

McNeill

Basu

et al. 1991

J. Clin. Biochem. Nutr.

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“…Independent studies carried out more than eighty years ago also found that about 85% of adult patients with type 2 diabetes had elevated plasma carotene levels, and more than 10% were clinically diagnosed with xanthosis [ 73 , 74 ]. Similar results were obtained to a lesser degree in type 2 diabetic children, but their plasma VA levels were found to be subnormal [ 75 ]. Additionally, reduction of serum retinol and RBP levels was found in type 1 diabetic patients [ 76 ].…”

Section: Va and Plasma Parameters: Clinical Evidencesupporting

confidence: 75%

The Roles of Vitamin A in the Regulation of Carbohydrate, Lipid, and Protein Metabolism

Chen

2014

JCM

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Currently, two-thirds of American adults are overweight or obese. This high prevalence of overweight/obesity negatively affects the health of the population, as obese individuals tend to develop several chronic diseases, such as type 2 diabetes and cardiovascular diseases. Due to obesity’s impact on health, medical costs, and longevity, the rise in the number of obese people has become a public health concern. Both genetic and environmental/dietary factors play a role in the development of metabolic diseases. Intuitively, it seems to be obvious to link over-nutrition to the development of obesity and other metabolic diseases. However, the underlying mechanisms are still unclear. Dietary nutrients not only provide energy derived from macronutrients, but also factors such as micronutrients with regulatory roles. How micronutrients, such as vitamin A (VA; retinol), regulate macronutrient homeostasis is still an ongoing research topic. As an essential micronutrient, VA plays a key role in the general health of an individual. This review summarizes recent research progress regarding VA’s role in carbohydrate, lipid, and protein metabolism. Due to the large amount of information regarding VA functions, this review focusses on metabolism in metabolic active organs and tissues. Additionally, some perspectives for future studies will be provided.

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“…Bowles reported a decrease in hepatic storage of vitamin A in rat in response to insulin [6], and Mosenthal and Laughlin suggested that diabetic children had lower levels of plasma vitamin A [7]. Recently, Basu et al [S] and Krempf et al [9] reported lower levels of plasma retinol and retinol binding protein (RBP) in patients with Type I diabetes.…”

mentioning

confidence: 99%

Vitamin A Homeostasis in the Diabetic Rat.

Tsin

Griffin

Mata

et al. 1993

J. Clin. Biochem. Nutr.

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SummaryThe concentrations of vitamin A (retinol) and retinyl ester in the plasma and liver of normal and diabetic rats were measured by HPLC (high-performance liquid chromatography). Diabetic rats had severe hyperglycemia, induced by a single streptozotocin injection 5 weeks prior to sampling. In the normal rats, plasma retinyl palmitate was very low, and the level was increased 10-fold by diabetes. Detailed timecourse studies showed that rats became hyperglycemic within 48 h of streptozotocin injection, yet the plasma retinyl palmitate level was not elevated until some three weeks later. Severe diabetes did not significantly influence plasma retinol; however, free retinol in the liver was elevated within 10 days of initiation of the disease and continued to increase for the duration of the study. These results show that streptozotocin-induced diabetes significantly alters the concentrations of hepatic retinol and plasma retinyl ester. The biochemical mechanism(s) of this altered vitamin A homeostasis in diabetes and its possible relationship to tissue pathogenesis are not known at present. Diabetes refers to metabolic disorders associated with hyperglycemia. Type I diabetes (juvenile-onset, insulin-dependent) is characterized by insulin deficiency; whereas in Type II diabetes (late-onset), the insulin level may be normal (or even elevated) but insulin is not effective in target organs. Various animal models have been developed to study the metabolic perturbations and underlying causes of diabetes mellitus [1,2]. In most of these experimental models, diabetes is induced

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Vitamins A, B and C in Diabetic Children

Cited by 14 publications

References 7 publications

Influence of Insulin on Plasma and Liver Vitamin A Levels in Diabetic Rats.

Influence of Insulin on Plasma and Liver Vitamin A Levels in Diabetic Rats.

The Roles of Vitamin A in the Regulation of Carbohydrate, Lipid, and Protein Metabolism

Vitamin A Homeostasis in the Diabetic Rat.

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