Vitamins and continuous ambulatory peritoneal dialysis (CAPD)

Mydlík, M; Derzsiová, K; Válek, A; Szabó, Tamás; Dandár, V.; Takač, Milena Jadrijević-Mladar

doi:10.1007/bf02085415

Cited by 24 publications

(10 citation statements)

References 3 publications

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“…The risk for patients on PD to develop ascorbate deficiency has been recognized over 20 years ago 25 . In our cohort of PD patients prevalence of ascorbate deficiency and insufficiency is high and seems to be commonly associated with lack of vitamin supplementation, despite dietary counselling at commencement of dialysis and advice regarding supplementation.…”

Section: Discussionmentioning

confidence: 83%

High prevalence of ascorbate deficiency in an Australian peritoneal dialysis population

et al. 2007

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Our results show that, in PD patients, ascorbate deficiency is common and can readily be identified with serum ascorbate measurements. Oral supplements in the form of inexpensive multivitamin preparations restore adequate serum ascorbate levels in the majority of these patients. We therefore suggest measurement of ascorbate levels in all PD patients at the commencement of dialysis with a target level in the normal range (4-14 mg/L).

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Section: Discussionmentioning

confidence: 83%

High prevalence of ascorbate deficiency in an Australian peritoneal dialysis population

et al. 2007

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“…In general, thiamine (32)(33)(34)(35) and riboflavin (16,34 -37) supply is considered to be normal in the majority of renal failure patients. However, some studies suggest the presence of thiamine (37)(38)(39) or riboflavin deficiency in renal failure patients (40), thus providing the rational basis for an association of vitamin B 1 or B 2 with hyperhomocysteinemia in ESRD pa- The lower the ␣-EGR, the better is the vitamin B 2 supply, resulting in low tHcy plasma levels.…”

Section: Discussionmentioning

confidence: 99%

Riboflavin Is a Determinant of Total Homocysteine Plasma Concentrations in End-Stage Renal Disease Patients

Skoupy¹,

Födinger²,

Veitl³

et al. 2002

Journal of the American Society of Nephrology

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Abstract. The effect of thiamine (vitamin B 1 ) or riboflavin (vitamin B 2 ) availability on fasting total homocysteine (tHcy) plasma levels in end-stage renal disease patients is unknown. A cross-sectional study was performed in a population of nonvitamin supplemented patients maintained on continuous ambulatory peritoneal dialysis. Red blood cell availability of thiamine (␣-ETK) and of riboflavin (␣-EGR), along with other predictors of tHcy plasma levels, was considered in the analysis. There was a linear association of ␣-EGR with tHcy plasma concentrations (P ϭ 0.009), which was not observed for ␣-ETK. Among red blood cell vitamins, ␣-EGR was the only predictor of tHcy levels (P ϭ 0.035), whereas ␣-ETK, red blood cell pyridoxal-5-phosphate supply (␣-EGOT) and red blood cell folate levels had no effect. The risk for having a high tHcy plasma levels within the fourth quartile (plasma tHcy Ͼ38.3 mol/L) was increased by an ␣-EGR Ͼ median (odds ratio, 4.706; 95% confidence interval, 1.124 to 19.704; P ϭ 0.026). By way of contrast, ␣-ETK had no effect in these analyses. Independent predictors of tHcy plasma levels were serum albumin, ␣-EGR, red blood cell folate, and certain MTHFR genotypes. A logistic regression analysis showed that the MTHFR genotype is a predictor for having a tHcy plasma concentration within the fourth quartile. In summary, riboflavin availability, as measured by ␣-EGR, is a determinant of fasting tHcy plasma levels in peritoneal dialysis patients. This finding may have implications for tHcy lowering therapy in individuals with end-stage renal disease.The majority of patients with impaired renal function present elevated total homocysteine (tHcy) plasma levels (1). Established predictors of tHcy plasma levels in the renal failure population include serum albumin and serum creatinine levels, creatinine clearance, folate status, vitamin B 12 and vitamin B 6 levels, as well as genetic variants in enzymes involved in the folate cycle or in the remethylation of homocysteine (2-7). An elevated tHcy plasma level can indicate folate and/or vitamin B 12 deficiency (8) and is associated with a variety of pathologic conditions such as vascular disease (9 -11) or birth defects (12). Although genetic and nongenetic factors have been shown to determine tHcy concentrations of patients with renal insufficiency, the cause of hyperhomocysteinemia among these patients is not completely understood (13).The role of B-group vitamins other than vitamin B 6 or vitamin B 12 as determinants of hyperhomocysteinemia in the general population and in the setting of renal insufficiency is far from clear, although vitamin B 1 (thiamine pyrophosphate) and vitamin B 2 (riboflavin) are involved in the metabolism of methionine and homocysteine.We assumed that thiamine or riboflavin availability is a predictor of fasting tHcy plasma levels in end-stage renal disease (ESRD). To test this hypothesis, we performed a crosssectional study among a population of non-vitamin supplemented patients maintained on continuous ambulatory perito...

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“…During the study, patients were advised to consume an unrestricted protein diet without vitamin C supplementation. All patients were supplemented by pyridoxine hydrochloride (5 mg/day without EPO treatment or 20 mg/day during EPO treatment) ( 18–20).…”

Section: Methodsmentioning

confidence: 99%

Peritoneal Clearance and Peritoneal Transfer of Oxalic Acid, Vitamin C, and Vitamin B₆ During Continuous Ambulatory Peritoneal Dialysis

Mydlík

Derzsiová

Svác³

et al. 1998

Artificial Organs

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The peritoneal clearance and peritoneal transfer of oxalic acid, vitamin C, and vitamin B6 in 32 patients during continuous ambulatory peritoneal dialysis (CAPD) using peritoneal dialysis solutions containing 1.5% or 2.5% glucose were examined. The plasma level of oxalic acid was significantly elevated in all patients, plasma vitamin C was in the normal range or in the upper margin of the normal range, and plasma vitamin B6 was in the normal range. The peritoneal clearance of oxalic acid was significantly lower, and the peritoneal clearance of vitamin B6 was the lowest in comparison to the peritoneal clearance of urea. With the exception of vitamin B6, the peritoneal clearance and peritoneal transfer of the examined parameters increased using the dialysis solution containing 2.5% glucose. We found direct relationships between the plasma levels of oxalic acid and creatinine as well as plasma vitamin C and between the peritoneal transfer of oxalic acid and the peritoneal transfer of vitamin C as well as vitamin B6. The significant hyperoxalemia of our patients was found to persist despite the relatively high peritoneal transfer of oxalic acid during CAPD. These results suggest that CAPD is not a method effective enough for permanent reduction of the plasma levels of oxalic acid.

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Vitamins and continuous ambulatory peritoneal dialysis (CAPD)

Cited by 24 publications

References 3 publications

High prevalence of ascorbate deficiency in an Australian peritoneal dialysis population

High prevalence of ascorbate deficiency in an Australian peritoneal dialysis population

Riboflavin Is a Determinant of Total Homocysteine Plasma Concentrations in End-Stage Renal Disease Patients

Peritoneal Clearance and Peritoneal Transfer of Oxalic Acid, Vitamin C, and Vitamin B₆ During Continuous Ambulatory Peritoneal Dialysis

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Vitamins and continuous ambulatory peritoneal dialysis (CAPD)

Cited by 24 publications

References 3 publications

High prevalence of ascorbate deficiency in an Australian peritoneal dialysis population

High prevalence of ascorbate deficiency in an Australian peritoneal dialysis population

Riboflavin Is a Determinant of Total Homocysteine Plasma Concentrations in End-Stage Renal Disease Patients

Peritoneal Clearance and Peritoneal Transfer of Oxalic Acid, Vitamin C, and Vitamin B6 During Continuous Ambulatory Peritoneal Dialysis

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Peritoneal Clearance and Peritoneal Transfer of Oxalic Acid, Vitamin C, and Vitamin B₆ During Continuous Ambulatory Peritoneal Dialysis