Vitiligo Improvement in a Hepatitis C Patient After Treatment With PEG-Interferon α-2A and Ribavirin: A Case Report

Taffaro, M.; Pyrsopoulos, Nikolaos; Cheng, Hugo Cedrón; Cacayorin, Edwin D.; Weppler, D.; Moon, Jang; Nishida, Seigo; Levi, David; Kato, Tomoaki; Selvaggi, Gennaro; Tzakis, Andreas G.; Schiff, Eugene R.

doi:10.1007/s10620-006-9721-0

Cited by 7 publications

(5 citation statements)

References 13 publications

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“…In the present study patients with vitiligo did not show neither improvement nor worsening of their lesion after treatment with DAAs. While, Taffaro et al, 2006 36 reported for the first time a patient with chronic HCV and vitiligo that significantly improved with initiation of antiviral therapy with Interferon α ‐2a and Ribavirin.…”

Section: Discussionmentioning

confidence: 99%

Hepatitis C virus associated skin manifestations in upper Egypt: Before and after direct acting antiviral treatment

Tawfik

Hassany

Badran

et al. 2020

Dermatologic Therapy

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Egypt displays a high-hepatitis C virus (HCV) burden and almost 20% of the patients develop cutaneous manifestations HCV-related. Direct acting antivirals (DAAs) drastically changed HCV patient's morbidity and mortality but their impact of the cutaneous manifestations remains elusive. Our aim was to find out the prevalence of different dermatological manifestations accompaning HCV infection in Egyptian patients. Also, to highlight the impact of DAAs on such manifestations and any potential dermatological side effects. A descriptive study was carried out at the

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Section: Discussionmentioning

confidence: 99%

Hepatitis C virus associated skin manifestations in upper Egypt: Before and after direct acting antiviral treatment

Tawfik

Hassany

Badran

et al. 2020

Dermatologic Therapy

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“…3 The frequent skin manifestations described with HCV infection include vasculitis associated with cryoglobulinemia, lichen planus, porphyria cutaneatarda, necrolyticacral erythema, erythema multiforme, erythema nodosum, pruritus and psoriasis. 4 Vitiligo affects 1% of the general population. 3 It is an acquired depigmenting disorder of the skin in which melanocytes are destroyed.…”

Section: Discussionmentioning

confidence: 99%

Reversal of Vitiligo with Cure from Hepatitis-C Infection

Nagral¹

2018

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“…Interestingly, Taffaro et al [18] reported a chronic hepatitis C patient whose old vitiligo lesions improved after initiation of PEG-IFN-α 2a and ribavirin therapy. It may be a result of immune modulation by PEG-IFN.…”

Section: Discussionmentioning

confidence: 99%

Vitiligo at Injection Site of PEG-IFN-α 2a in Two Patients with Chronic Hepatitis C: Case Report and Literature Review

Arya

Bansal²,

Girard³

et al. 2010

Case Rep Dermatol

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A 72-year-old female and a 57-year-old male with chronic hepatitis C were treated with a combination therapy of pegylated interferon (PEG-IFN)-α 2a (180 µg s.c. once a week) and ribavirin (1,000 mg orally daily). This resulted in the destruction of melanocytes at the injection site in both patients. In the male patient, the depigmentation progressed to the surrounding skin area. The dermatologist concurred with vitiligo as the diagnosis in both patients. Injection and surrounding site vitiligo associated with PEG-IFN-α 2b treatment for hepatitis C was noticed in previous case studies. For the first time, the case reports below highlight the same immunological adverse event secondary to PEG IFN-α 2a/ribavirin combination therapy and explain, in part, the complex interaction between host immune response and viral genotype. In addition, we systematically review drug-induced vitiligo and autoimmune diseases associated with the depigmentation disorder.

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Vitiligo Improvement in a Hepatitis C Patient After Treatment With PEG-Interferon α-2A and Ribavirin: A Case Report

Cited by 7 publications

References 13 publications

Hepatitis C virus associated skin manifestations in upper Egypt: Before and after direct acting antiviral treatment

Hepatitis C virus associated skin manifestations in upper Egypt: Before and after direct acting antiviral treatment

Reversal of Vitiligo with Cure from Hepatitis-C Infection

Vitiligo at Injection Site of PEG-IFN-α 2a in Two Patients with Chronic Hepatitis C: Case Report and Literature Review

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