Vitiligo with inflammatory raised borders with hepatitis C virus infection

Tsuboi, Hiromi; Yonemoto, Kohzoh; Katsuoka, Kensei

doi:10.1111/j.1346-8138.2006.00135.x

Cited by 16 publications

(16 citation statements)

References 8 publications

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“…Pruritus has been reported in association with these signs. Lesions with raised/erythematous borders, erythema, plaques, marginal scaling and/or hyperpigmentation showed significantly higher frequency of inflammatory cellular infiltrates . Inflammatory vitiligo has also been linked to clinical progression over time .…”

Section: Resultsmentioning

confidence: 99%

Clinical visible signs of disease activity in vitiligo: a systematic review and meta‐analysis

Geel

Grine

Wispelaere

et al. 2019

Acad Dermatol Venereol

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Vitiligo is an unpredictable depigmenting disorder for which a static method to assess disease activity is lacking. Presence of certain skin manifestations may be indicative of disease activity. Here, we evaluated the current evidence for an association between clinical signs and reported disease activity in vitiligo. A systematic review and meta‐analysis was performed based on a search in PubMed, Embase and Cochrane Library. Literature reporting skin manifestations and disease activity was analysed based on descriptive analyses and, if applicable, odd ratios. Forty‐six observational studies were selected and analysed, including 28 case reports. Reported clinical signs in relation to active vitiligo were as follows: Koebner's phenomenon, confetti‐like depigmentations, tri‐ and hypochromic lesions (including poorly defined borders), inflammatory borders/areas, itch and leukotrichia. Based on this search, strong evidence was found for Koebner's phenomenon. Poorly defined borders and confetti lesions are potential markers, although more data are needed to confirm this. Evidence for other skin manifestations was inconclusive, whereas case reports on inflammatory borders were indicative of active disease. Limitations included the lack of randomized controlled trials, large‐scale prospective studies and heterogeneity due to inconsistent definitions. This systematic review urges the vitiligo community to come forward with consensus‐based definitions as well as a reliable scoring system to assess these clinical signs and to design optimal trials to investigate their true predictive value.

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Section: Resultsmentioning

confidence: 99%

Clinical visible signs of disease activity in vitiligo: a systematic review and meta‐analysis

Geel

Grine

Wispelaere

et al. 2019

Acad Dermatol Venereol

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“…In the relatively few published reports of this variant, it is seen to occur at any age and affects both sexes equally, with some reports identifying its presentation in patients with a history of atopic dermatitis, hepatitis C, and Sjogren's syndrome. [123]…”

Section: Discussionmentioning

confidence: 99%

Inflammatory vitiligo versus hypopigmented mycosis fungoides in a 58-year-old Indian female

Soro

Gust

Purcell

2013

Indian Dermatol Online J

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Vitiligo, particularly the rarer inflammatory variant, may be difficult to distinguish from hypopigmented mycosis fungoides (MF) clinically. Complicating the distinction is that when biopsies are taken from the periphery of early vitiliginous lesions or from lesions with an inflammatory border (inflammatory vitiligo), a dermal lymphocytic infiltrate, exocytosis, interface dermatitis, and mild spongiosis may be seen, all resembling the findings seen in hypopigmented MF. We present a case demonstrating the difficulty in differentiating between these two diseases and examine some characteristic clinical and histopathological features of each. Often, a conclusive diagnosis cannot be made, necessitating close follow-up of the patient and monitoring for progression of their disease over time.

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“…Two reports of psoralen plus ultraviolet A (PUVA) were found. Treatment of one case with PUVA and oral prednisolone led to improvement of erythema and depigmentation after 2 months of therapy [10]. The second case subject was treated with 6 months of PUVA alone with no reported improvement at the 3- and 6-month follow-ups, but disease stability was achieved [9].…”

Section: Discussionmentioning

confidence: 99%

Repigmentation of Extensive Inflammatory Vitiligo with Raised Borders Using Early and Aggressive Treatment

Gunasekera

Murphy²,

Sheth³

2014

Dermatology

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Inflammatory vitiligo with raised borders (IVRB) is a rare subtype of vitiligo described as having a rim of raised erythema at the periphery of the depigmented patches. The etiology is poorly understood, and there are few reports of successful treatment of the condition in the literature. We report a 38-year-old South Asian male who presented with diffuse depigmented macules and patches surrounded by blue-gray rims involving a large body surface area. Light microscopy revealed inflammatory vitiligo. He was treated with 2 courses of oral prednisone and whole-body narrow-band ultraviolet B (NB-UVB) therapy, which resulted in cessation of disease spread as well as substantial repigmentation. Our observation suggests that early and aggressive treatment can lead to significant and rapid improvement in patients with IVRB.

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Vitiligo with inflammatory raised borders with hepatitis C virus infection

Cited by 16 publications

References 8 publications

Clinical visible signs of disease activity in vitiligo: a systematic review and meta‐analysis

Clinical visible signs of disease activity in vitiligo: a systematic review and meta‐analysis

Inflammatory vitiligo versus hypopigmented mycosis fungoides in a 58-year-old Indian female

Repigmentation of Extensive Inflammatory Vitiligo with Raised Borders Using Early and Aggressive Treatment

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