Vitreoretinal surgery for cystoid macular edema associated with retinitis pigmentosa

García‐Arumí, José; Martínez, Vicente; Sararols, Laura; Corcóstegui, Borja

doi:10.1016/s0161-6420(03)00259-8

Cited by 65 publications

(42 citation statements)

References 22 publications

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“…Several therapies are used to treat CME in RP patients and include topical or oral administration of carbonic anhydrase inhibitor, [1][2][3][4] periocular or intravitreal injection of steroid, [5][6][7][8][9] intravitreal injection of bevacizumab, 10 photocoagulation, 11,12 or vitrectomy. 13 Although each of these therapeutic measures provides a benefit for some of the patients, there is little information on the pathophysiology, prevalence, or natural course of CME that is associated with RP. Furthermore, because of the nature of the pathological and clinical characteristics of RP, it can be quite difficult to assess the involvement of CME in the visual impairment of RP patients as compared to that for other retinal vascular diseases.…”

Section: Introductionmentioning

confidence: 99%

Photoreceptor integrity and visual acuity in cystoid macular oedema associated with retinitis pigmentosa

Oishi

Otani

Sasahara

et al. 2008

Eye

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Aims To assess the correlation between macular morphology and visual acuity in retinitis pigmentosa (RP) patients with cystoid macular oedema (CME). Design Retrospective cross-sectional study. Patients and methods Forty-one eyes of 25 RP patients with CME. Patients underwent cross-sectional scans with optical coherence tomography (Stratus OCT). Age, total retinal thickness, photoreceptor thickness, and the transverse and vertical lengths of the cystoid space were measured. Correlation between visual acuity and each of the measurements were examined. Additionally, the status of the inner segment/outer segment junction (IS/OS) was classified as being absent, discontinuous, or distinct. Measurements were then compared among the three groups. Results Total retinal thickness or photoreceptor thickness was not correlated with visual acuity. There was a correlation between the transverse length of the cystoid space and visual acuity, although the correlation coefficient was weak (r ¼ 0.30). The logMAR visual acuity in the IS/OS absent group (0.67±0.43) was worse than that seen in the IS/OS discontinuous (0.22 ± 0.19) or IS/OS distinct groups (0.07 ± 0.16) (Po0.001). Conclusions When monitoring CME associated with RP, the status of IS/OS is the essential parameter that needs to be examined.

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Section: Introductionmentioning

confidence: 99%

Photoreceptor integrity and visual acuity in cystoid macular oedema associated with retinitis pigmentosa

Oishi

Otani

Sasahara

et al. 2008

Eye

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“…We and others reported the long-term surgical outcomes of pars plana vitrectomy (PPV) against ERM in RP patients. 6,32,33 The results showed that PPV with internal limiting membrane peeling improves macular morphology, although it does not provide a significant improvement of visual acuity or metamorphopsia. The prevention of ERM formation or progression will thus be required to prevent vision loss due to macular complications in RP.…”

Section: Discussionmentioning

confidence: 99%

Association Between Aqueous Flare and Epiretinal Membrane in Retinitis Pigmentosa

Fujiwara

Ikeda

Murakami

et al. 2016

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. Epiretinal membrane (ERM) is a frequent macular complication in patients with retinitis pigmentosa (RP). The etiology of ERM formation in RP is largely unknown. The purpose of this study was to investigate the association between aqueous flare, a surrogate index of intraocular inflammation, and ERM secondary to RP. METHODS.We retrospectively studied a total of 206 eyes of 117 patients who were diagnosed with typical RP. Aqueous flare values were measured consecutively in 2012 and 2013 using a laser flare cell meter. Spectral-domain optical coherence tomography images and fundus photographs taken on the same day of the aqueous flare measurements were analyzed for ERM detection. RESULTS.The mean values of aqueous flare, age, and frequency of male sex were significantly higher in the RP patients with ERM compared with the RP patients without ERM (P < 0.0001, P ¼ 0.007, and P ¼ 0.004, respectively). After adjustment for age and sex, the eyes in the highest quartile of aqueous flare had significantly higher odds of having ERM than those in the lowest quartile (odds ratio [OR], 2.68; 95% confidence interval [CI], 1.04-6.93), and the linear trend across flare levels was significant (P ¼ 0.005). In addition, each 1-log-transformed increase in flare values was associated with an elevation of the likelihood of having ERM (OR, 2.59; 95% CI, 1.33-5.06).CONCLUSIONS. Our analysis demonstrated that elevated aqueous flare is associated with ERM secondary to RP, suggesting that inflammation may be implicated in the pathogenesis of ERM formation in RP.

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“…According to previous studies, the most effective therapies seem to be acetazolamide and corticosteroids. [8][9][10][11][12] Intravitreal triamcinolone acetonide has already been used in different retinal pathological conditions complicated by CME in their clinical development. 13 The purpose of our study was to evaluate the anatomical and visual results of treatment with intravitreal triamcinolone injections in patients with CME secondary to RP.…”

Section: Discussionmentioning

confidence: 99%

Treatment of Cystoid Macular Edema in Retinitis Pigmentosa With Intravitreal Triamcinolone

Scorolli

Morara²,

Meduri³

et al. 2007

Arch Ophthalmol

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Vitreoretinal surgery for cystoid macular edema associated with retinitis pigmentosa

Cited by 65 publications

References 22 publications

Photoreceptor integrity and visual acuity in cystoid macular oedema associated with retinitis pigmentosa

Photoreceptor integrity and visual acuity in cystoid macular oedema associated with retinitis pigmentosa

Association Between Aqueous Flare and Epiretinal Membrane in Retinitis Pigmentosa

Treatment of Cystoid Macular Edema in Retinitis Pigmentosa With Intravitreal Triamcinolone

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